Treatments targeting inotropy
Beteiligte Einrichtungen
Abstract
suggested that levosimendan is associated with a better outcome than dobutamine, larger comparative trials failed to confirm this observation. For omecamtiv mecarbil, phase II clinical trials suggest a favorable hemodynamic profile in patients with acute and chronic heart failure, and a phase III morbidity/mortality trial in patients with chronic heart failure has recently begun. Here, we review the pathophysiological basis of systolic dysfunction in patients with heart failure and the mechanisms through which different inotropic agents improve cardiac function. Since adenosine triphosphate and reactive oxygen species production in mitochondria are intimately linked to the processes of excitation-contraction coupling, we also discuss the impact
of inotropic agents on mitochondrial bioenergetics and redox regulation. Therefore, this position paper should help identify novel targets for treatments that could not only safely improve systolic and diastolic function acutely, but potentially also myocardial structure and function over a longer term.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 0195-668X |
DOIs | |
Status | Veröffentlicht - 2018 |