Treatment reality in elderly patients with advanced ovarian cancer: a prospective analysis of the OVCAD consortium

TY - JOUR

T1 - Treatment reality in elderly patients with advanced ovarian cancer: a prospective analysis of the OVCAD consortium

AU - Trillsch, Fabian

AU - Woelber, Linn

AU - zu Eulenburg, Christine

AU - Braicu, Ioana

AU - Lambrechts, Sandrina

AU - Chekerov, Radoslav

AU - van Nieuwenhuysen, Els

AU - Speiser, Paul

AU - Zeimet, Alain

AU - Castillo-Tong, Dan Cacsire

AU - Concin, Nicole

AU - Zeillinger, Robert

AU - Vergote, Ignace

AU - Mahner, Sven

AU - Sehouli, Jalid

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BACKGROUND: Approximately one third of women diagnosed with ovarian cancer is 70 years or older. Information on the treatment reality of these elderly patients is limited.METHODS: 275 patients with primary epithelial ovarian cancer FIGO stage II-IV undergoing cytoreductive surgery and platinum-based chemotherapy were prospectively included in this European multicenter study. Patients <70 and ≥70 years were compared regarding clinicopathological variables and prognosis.RESULTS: Median age was 58 years (18-85); 47 patients (17.1%) were 70 years or older. The postoperative 60-day-mortality rate was 2.1% for elderly and 0.4% for younger patients (p < 0.001). Elderly patients were less likely to receive optimal therapy (no residual disease after surgery and platinum combination chemotherapy) compared to patients <70 years (40.4% vs. 70.1%, p < 0.001) and their outcome was less favorable regarding median PFS (12 vs. 20 months, p = 0.022) and OS (30 vs. 64 months, p < 0.001). However, in multivariate analysis age itself was not a prognostic factor for PFS while the ECOG performance status had prognostic significance in elderly patients.CONCLUSIONS: Elderly patients with ovarian cancer are often treated less radically. Their outcome is impaired despite no consistent prognostic effect of age itself. Biological age and functional status should be considered before individualized treatment plans are defined.

AB - BACKGROUND: Approximately one third of women diagnosed with ovarian cancer is 70 years or older. Information on the treatment reality of these elderly patients is limited.METHODS: 275 patients with primary epithelial ovarian cancer FIGO stage II-IV undergoing cytoreductive surgery and platinum-based chemotherapy were prospectively included in this European multicenter study. Patients <70 and ≥70 years were compared regarding clinicopathological variables and prognosis.RESULTS: Median age was 58 years (18-85); 47 patients (17.1%) were 70 years or older. The postoperative 60-day-mortality rate was 2.1% for elderly and 0.4% for younger patients (p < 0.001). Elderly patients were less likely to receive optimal therapy (no residual disease after surgery and platinum combination chemotherapy) compared to patients <70 years (40.4% vs. 70.1%, p < 0.001) and their outcome was less favorable regarding median PFS (12 vs. 20 months, p = 0.022) and OS (30 vs. 64 months, p < 0.001). However, in multivariate analysis age itself was not a prognostic factor for PFS while the ECOG performance status had prognostic significance in elderly patients.CONCLUSIONS: Elderly patients with ovarian cancer are often treated less radically. Their outcome is impaired despite no consistent prognostic effect of age itself. Biological age and functional status should be considered before individualized treatment plans are defined.

U2 - 10.1186/1757-2215-6-42

DO - 10.1186/1757-2215-6-42

M3 - SCORING: Journal article

C2 - 23809664

VL - 6

SP - 42

JO - J OVARIAN RES

JF - J OVARIAN RES

SN - 1757-2215

IS - 1

ER -