Treatment of imported severe malaria with artesunate instead of quinine--more evidence needed?
Standard
Treatment of imported severe malaria with artesunate instead of quinine--more evidence needed? / Cramer, Jakob; López-Vélez, Rogelio; Burchard, Gerd-Dieter; Grobusch, Martin P; Vries, de; Peter, J.
in: MALARIA J, Jahrgang 10, 2011, S. 256.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Treatment of imported severe malaria with artesunate instead of quinine--more evidence needed?
AU - Cramer, Jakob
AU - López-Vélez, Rogelio
AU - Burchard, Gerd-Dieter
AU - Grobusch, Martin P
AU - Vries, de
AU - Peter, J
PY - 2011
Y1 - 2011
N2 - Rapid and fast acting anti-malarials are essential to treat severe malaria. Quinine has been the only option for parenteral therapy until recently. While current evidence shows that intravenous artesunate is more effective than quinine in treating severe malaria in endemic countries, some questions remain regarding safety profiles and drug resistance. For imported severe malaria, additional unanswered questions are related to generalizability of the findings from endemic countries and to legal aspects, as there is no Good Manufacturing Practice-conform drug available yet. Here, the implications of existing evidence for the treatment of imported severe malaria are discussed.
AB - Rapid and fast acting anti-malarials are essential to treat severe malaria. Quinine has been the only option for parenteral therapy until recently. While current evidence shows that intravenous artesunate is more effective than quinine in treating severe malaria in endemic countries, some questions remain regarding safety profiles and drug resistance. For imported severe malaria, additional unanswered questions are related to generalizability of the findings from endemic countries and to legal aspects, as there is no Good Manufacturing Practice-conform drug available yet. Here, the implications of existing evidence for the treatment of imported severe malaria are discussed.
KW - Humans
KW - Injections, Intravenous
KW - Antimalarials/administration & dosage
KW - Artemisinins/administration & dosage/adverse effects
KW - Malaria/drug therapy
KW - Quinine/administration & dosage
KW - Humans
KW - Injections, Intravenous
KW - Antimalarials/administration & dosage
KW - Artemisinins/administration & dosage/adverse effects
KW - Malaria/drug therapy
KW - Quinine/administration & dosage
U2 - 10.1186/1475-2875-10-256
DO - 10.1186/1475-2875-10-256
M3 - SCORING: Journal article
VL - 10
SP - 256
JO - MALARIA J
JF - MALARIA J
SN - 1475-2875
ER -