Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors.
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Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors. / Sommer, Frank; Schulze, Wolfgang.
in: WORLD J UROL, Jahrgang 23, Nr. 6, 6, 2005, S. 385-392.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors.
AU - Sommer, Frank
AU - Schulze, Wolfgang
PY - 2005
Y1 - 2005
N2 - A large body of evidence has accumulated demonstrating that a common pathway in conditions such as hypertension, atherosclerosis, hypercholesterolemia, diabetes mellitus, and erectile dysfunction (ED) is endothelial dysfunction. Although a complete pharmacological cure for ED is currently unavailable, the phosphodiesterase 5 (PDE5) inhibitors sildenafil, vardenafil, and tadalafil are efficacious oral therapy for ED. Results from recent studies suggest that regular treatment with a PDE5 inhibitor may lead to enhanced erectile function (EF) beyond that observed with on-demand usage, possibly through improvement of endothelial function. Such an effect may be viewed as rehabilitation of damaged erectile tissue. The present review focuses on several recent studies which provide evidence for the beneficial effect of regular PDE5 inhibitor administration on the improvement of EF by rehabilitation of vascular endothelium.
AB - A large body of evidence has accumulated demonstrating that a common pathway in conditions such as hypertension, atherosclerosis, hypercholesterolemia, diabetes mellitus, and erectile dysfunction (ED) is endothelial dysfunction. Although a complete pharmacological cure for ED is currently unavailable, the phosphodiesterase 5 (PDE5) inhibitors sildenafil, vardenafil, and tadalafil are efficacious oral therapy for ED. Results from recent studies suggest that regular treatment with a PDE5 inhibitor may lead to enhanced erectile function (EF) beyond that observed with on-demand usage, possibly through improvement of endothelial function. Such an effect may be viewed as rehabilitation of damaged erectile tissue. The present review focuses on several recent studies which provide evidence for the beneficial effect of regular PDE5 inhibitor administration on the improvement of EF by rehabilitation of vascular endothelium.
M3 - SCORING: Zeitschriftenaufsatz
VL - 23
SP - 385
EP - 392
JO - WORLD J UROL
JF - WORLD J UROL
SN - 0724-4983
IS - 6
M1 - 6
ER -
