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Transplantation of oligodendrocyte progenitor cells into the rat retina

Standard

Transplantation of oligodendrocyte progenitor cells into the rat retina : extensive myelination of retinal ganglion cell axons. / Laeng, P; Molthagen, M; Yu, E G; Bartsch, U.

in: GLIA, Jahrgang 18, Nr. 3, 11.1996, S. 200-10.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Laeng, P, Molthagen, M, Yu, EG & Bartsch, U 1996, 'Transplantation of oligodendrocyte progenitor cells into the rat retina: extensive myelination of retinal ganglion cell axons', GLIA, Jg. 18, Nr. 3, S. 200-10. https://doi.org/10.1002/(SICI)1098-1136(199611)18:3<200::AID-GLIA4>3.0.CO;2-2

APA

Laeng, P., Molthagen, M., Yu, E. G., & Bartsch, U. (1996). Transplantation of oligodendrocyte progenitor cells into the rat retina: extensive myelination of retinal ganglion cell axons. GLIA, 18(3), 200-10. https://doi.org/10.1002/(SICI)1098-1136(199611)18:3<200::AID-GLIA4>3.0.CO;2-2

Vancouver

Laeng P, Molthagen M, Yu EG, Bartsch U. Transplantation of oligodendrocyte progenitor cells into the rat retina: extensive myelination of retinal ganglion cell axons. GLIA. 1996 Nov;18(3):200-10. https://doi.org/10.1002/(SICI)1098-1136(199611)18:3<200::AID-GLIA4>3.0.CO;2-2

Bibtex

@article{6c50453cf02f41d3a2f5720f6805fc58,
title = "Transplantation of oligodendrocyte progenitor cells into the rat retina: extensive myelination of retinal ganglion cell axons",
abstract = "In most mammals, retinal ganglion cell axons are unmyelinated in the retina. The same axons become myelinated in the optic nerve. Various studies suggest that retinal ganglion cell axons are also in principle, myelination competent intraretinally and that non-neuronal factors at the retinal end of the optic nerve prevent the migration of oligodendrocyte progenitor cells into the retina. To test this hypothesis directly, we injected oligodendrocyte progenitor cells into the retina of young postnatal rats. We observed massive myelination of ganglion cell axons in the retina 1 month after cell transplantation. Electron microscopic analysis revealed that intraretinal segments of ganglion cell axons were surrounded by central nervous system myelin sheaths with a normal morphology. Our results thus provide direct evidence for the myelination competence of the intraretinal part of rat retinal ganglion cell axons.",
keywords = "Animals, Axons, Cell Transplantation, Immunohistochemistry, In Situ Hybridization, Microscopy, Electron, Myelin Sheath, Oligodendroglia, RNA Probes, Rats, Rats, Sprague-Dawley, Retina, Retinal Ganglion Cells, Stem Cell Transplantation, Stem Cells, Journal Article, Research Support, Non-U.S. Gov't",
author = "P Laeng and M Molthagen and Yu, {E G} and U Bartsch",
year = "1996",
month = nov,
doi = "10.1002/(SICI)1098-1136(199611)18:3<200::AID-GLIA4>3.0.CO;2-2",
language = "English",
volume = "18",
pages = "200--10",
journal = "GLIA",
issn = "0894-1491",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Transplantation of oligodendrocyte progenitor cells into the rat retina

T2 - extensive myelination of retinal ganglion cell axons

AU - Laeng, P

AU - Molthagen, M

AU - Yu, E G

AU - Bartsch, U

PY - 1996/11

Y1 - 1996/11

N2 - In most mammals, retinal ganglion cell axons are unmyelinated in the retina. The same axons become myelinated in the optic nerve. Various studies suggest that retinal ganglion cell axons are also in principle, myelination competent intraretinally and that non-neuronal factors at the retinal end of the optic nerve prevent the migration of oligodendrocyte progenitor cells into the retina. To test this hypothesis directly, we injected oligodendrocyte progenitor cells into the retina of young postnatal rats. We observed massive myelination of ganglion cell axons in the retina 1 month after cell transplantation. Electron microscopic analysis revealed that intraretinal segments of ganglion cell axons were surrounded by central nervous system myelin sheaths with a normal morphology. Our results thus provide direct evidence for the myelination competence of the intraretinal part of rat retinal ganglion cell axons.

AB - In most mammals, retinal ganglion cell axons are unmyelinated in the retina. The same axons become myelinated in the optic nerve. Various studies suggest that retinal ganglion cell axons are also in principle, myelination competent intraretinally and that non-neuronal factors at the retinal end of the optic nerve prevent the migration of oligodendrocyte progenitor cells into the retina. To test this hypothesis directly, we injected oligodendrocyte progenitor cells into the retina of young postnatal rats. We observed massive myelination of ganglion cell axons in the retina 1 month after cell transplantation. Electron microscopic analysis revealed that intraretinal segments of ganglion cell axons were surrounded by central nervous system myelin sheaths with a normal morphology. Our results thus provide direct evidence for the myelination competence of the intraretinal part of rat retinal ganglion cell axons.

KW - Animals

KW - Axons

KW - Cell Transplantation

KW - Immunohistochemistry

KW - In Situ Hybridization

KW - Microscopy, Electron

KW - Myelin Sheath

KW - Oligodendroglia

KW - RNA Probes

KW - Rats

KW - Rats, Sprague-Dawley

KW - Retina

KW - Retinal Ganglion Cells

KW - Stem Cell Transplantation

KW - Stem Cells

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/(SICI)1098-1136(199611)18:3<200::AID-GLIA4>3.0.CO;2-2

DO - 10.1002/(SICI)1098-1136(199611)18:3<200::AID-GLIA4>3.0.CO;2-2

M3 - SCORING: Journal article

C2 - 8915652

VL - 18

SP - 200

EP - 210

JO - GLIA

JF - GLIA

SN - 0894-1491

IS - 3

ER -