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Transferrin-coated gadolinium nanoparticles as MRI contrast agent

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Transferrin-coated gadolinium nanoparticles as MRI contrast agent. / Korkusuz, Huedayi; Ulbrich, Karsten; Welzel, Katerina; Koeberle, Verena; Watcharin, Waralee; Bahr, Ute; Chernikov, Valery; Knobloch, Thomas; Petersen, Sabine; Huebner, Frank; Ackermann, Hanns; Gelperina, Svetlana; Kromen, Wolfgang; Hammerstingl, Renate; Haupenthal, Joerg; Gruenwald, Frank; Fiehler, Jens; Zeuzem, Stefan; Kreuter, Joerg; Vogl, Thomas J; Piiper, Albrecht.

in: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, Jahrgang 15, Nr. 2, 01.04.2013, S. 148-54.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Korkusuz, H, Ulbrich, K, Welzel, K, Koeberle, V, Watcharin, W, Bahr, U, Chernikov, V, Knobloch, T, Petersen, S, Huebner, F, Ackermann, H, Gelperina, S, Kromen, W, Hammerstingl, R, Haupenthal, J, Gruenwald, F, Fiehler, J, Zeuzem, S, Kreuter, J, Vogl, TJ & Piiper, A 2013, 'Transferrin-coated gadolinium nanoparticles as MRI contrast agent', Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, Jg. 15, Nr. 2, S. 148-54. https://doi.org/10.1007/s11307-012-0579-6

APA

Korkusuz, H., Ulbrich, K., Welzel, K., Koeberle, V., Watcharin, W., Bahr, U., Chernikov, V., Knobloch, T., Petersen, S., Huebner, F., Ackermann, H., Gelperina, S., Kromen, W., Hammerstingl, R., Haupenthal, J., Gruenwald, F., Fiehler, J., Zeuzem, S., Kreuter, J., ... Piiper, A. (2013). Transferrin-coated gadolinium nanoparticles as MRI contrast agent. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 15(2), 148-54. https://doi.org/10.1007/s11307-012-0579-6

Vancouver

Korkusuz H, Ulbrich K, Welzel K, Koeberle V, Watcharin W, Bahr U et al. Transferrin-coated gadolinium nanoparticles as MRI contrast agent. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2013 Apr 1;15(2):148-54. https://doi.org/10.1007/s11307-012-0579-6

Bibtex

@article{d25d9aac4f584d71b723b1eeee9f9a23,
title = "Transferrin-coated gadolinium nanoparticles as MRI contrast agent",
abstract = "PURPOSE: In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated.PROCEDURES: HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-HSA-NP-Tf). Mice underwent MRI before or after injection of Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-Tf.RESULTS: All the studied contrast agents provided a contrast enhancement (CE) in the blood, heart muscle, and liver. Compared to Gd-DTPA, CE with HSA-NP was achieved at lower Gd doses. Gd-HSA-NP-Tf yielded significantly higher CE than Gd-HSA-NP in the skeletal muscle, blood, cardiac muscle, and liver (p < 0.05). Gd-HSA-NP-Tf achieved a significantly higher CE than Gd-HSA-NP and Gd-DTPA in the blood, cardiac muscle, and liver (p < 0.05). In the brain, only Gd-HSA-NP-Tf was found to cause a significant CE (p < 0.05).CONCLUSIONS: The Gd-HSA nanoparticles have potential as MRI contrast agents. In particular, Gd-HSA-NP-Tf has a potential as a specific contrast agent for the brain, while the blood-brain barrier is still intact, as well as in the heart, liver, and skeletal muscle.",
keywords = "Albumins, Analysis of Variance, Animals, Contrast Media, Gadolinium DTPA, Humans, Magnetic Resonance Imaging, Male, Mice, Nanoparticles, Serum Albumin, Signal-To-Noise Ratio, Tissue Distribution, Transferrin",
author = "Huedayi Korkusuz and Karsten Ulbrich and Katerina Welzel and Verena Koeberle and Waralee Watcharin and Ute Bahr and Valery Chernikov and Thomas Knobloch and Sabine Petersen and Frank Huebner and Hanns Ackermann and Svetlana Gelperina and Wolfgang Kromen and Renate Hammerstingl and Joerg Haupenthal and Frank Gruenwald and Jens Fiehler and Stefan Zeuzem and Joerg Kreuter and Vogl, {Thomas J} and Albrecht Piiper",
year = "2013",
month = apr,
day = "1",
doi = "10.1007/s11307-012-0579-6",
language = "English",
volume = "15",
pages = "148--54",
journal = "MOL IMAGING BIOL",
issn = "1536-1632",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - Transferrin-coated gadolinium nanoparticles as MRI contrast agent

AU - Korkusuz, Huedayi

AU - Ulbrich, Karsten

AU - Welzel, Katerina

AU - Koeberle, Verena

AU - Watcharin, Waralee

AU - Bahr, Ute

AU - Chernikov, Valery

AU - Knobloch, Thomas

AU - Petersen, Sabine

AU - Huebner, Frank

AU - Ackermann, Hanns

AU - Gelperina, Svetlana

AU - Kromen, Wolfgang

AU - Hammerstingl, Renate

AU - Haupenthal, Joerg

AU - Gruenwald, Frank

AU - Fiehler, Jens

AU - Zeuzem, Stefan

AU - Kreuter, Joerg

AU - Vogl, Thomas J

AU - Piiper, Albrecht

PY - 2013/4/1

Y1 - 2013/4/1

N2 - PURPOSE: In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated.PROCEDURES: HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-HSA-NP-Tf). Mice underwent MRI before or after injection of Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-Tf.RESULTS: All the studied contrast agents provided a contrast enhancement (CE) in the blood, heart muscle, and liver. Compared to Gd-DTPA, CE with HSA-NP was achieved at lower Gd doses. Gd-HSA-NP-Tf yielded significantly higher CE than Gd-HSA-NP in the skeletal muscle, blood, cardiac muscle, and liver (p < 0.05). Gd-HSA-NP-Tf achieved a significantly higher CE than Gd-HSA-NP and Gd-DTPA in the blood, cardiac muscle, and liver (p < 0.05). In the brain, only Gd-HSA-NP-Tf was found to cause a significant CE (p < 0.05).CONCLUSIONS: The Gd-HSA nanoparticles have potential as MRI contrast agents. In particular, Gd-HSA-NP-Tf has a potential as a specific contrast agent for the brain, while the blood-brain barrier is still intact, as well as in the heart, liver, and skeletal muscle.

AB - PURPOSE: In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated.PROCEDURES: HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-HSA-NP-Tf). Mice underwent MRI before or after injection of Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-Tf.RESULTS: All the studied contrast agents provided a contrast enhancement (CE) in the blood, heart muscle, and liver. Compared to Gd-DTPA, CE with HSA-NP was achieved at lower Gd doses. Gd-HSA-NP-Tf yielded significantly higher CE than Gd-HSA-NP in the skeletal muscle, blood, cardiac muscle, and liver (p < 0.05). Gd-HSA-NP-Tf achieved a significantly higher CE than Gd-HSA-NP and Gd-DTPA in the blood, cardiac muscle, and liver (p < 0.05). In the brain, only Gd-HSA-NP-Tf was found to cause a significant CE (p < 0.05).CONCLUSIONS: The Gd-HSA nanoparticles have potential as MRI contrast agents. In particular, Gd-HSA-NP-Tf has a potential as a specific contrast agent for the brain, while the blood-brain barrier is still intact, as well as in the heart, liver, and skeletal muscle.

KW - Albumins

KW - Analysis of Variance

KW - Animals

KW - Contrast Media

KW - Gadolinium DTPA

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Mice

KW - Nanoparticles

KW - Serum Albumin

KW - Signal-To-Noise Ratio

KW - Tissue Distribution

KW - Transferrin

U2 - 10.1007/s11307-012-0579-6

DO - 10.1007/s11307-012-0579-6

M3 - SCORING: Journal article

C2 - 22811020

VL - 15

SP - 148

EP - 154

JO - MOL IMAGING BIOL

JF - MOL IMAGING BIOL

SN - 1536-1632

IS - 2

ER -