Trafficking of potassium channels
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Trafficking of potassium channels. / Heusser, Katja; Schwappach, Blanche.
in: CURR OPIN NEUROBIOL, Jahrgang 15, Nr. 3, 06.2005, S. 364-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Trafficking of potassium channels
AU - Heusser, Katja
AU - Schwappach, Blanche
PY - 2005/6
Y1 - 2005/6
N2 - Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the presence of two recently identified accessory subunits. Current advances are beginning to enable us to understand the Kv supermolecular complex containing these subunits in crystallographic detail. In addition, determinants that govern the dendritic or axonal targeting of Kv channels have also been identified. In terms of the bigger picture, the careful analysis of gene expression patterns in the brain paves the way for studying trafficking in a physiological context. Indeed, neuronal activity has recently been shown to fine-tune the localization of Kv2.1 channels in microdomains of the neuronal plasma membrane.
AB - Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the presence of two recently identified accessory subunits. Current advances are beginning to enable us to understand the Kv supermolecular complex containing these subunits in crystallographic detail. In addition, determinants that govern the dendritic or axonal targeting of Kv channels have also been identified. In terms of the bigger picture, the careful analysis of gene expression patterns in the brain paves the way for studying trafficking in a physiological context. Indeed, neuronal activity has recently been shown to fine-tune the localization of Kv2.1 channels in microdomains of the neuronal plasma membrane.
KW - Animals
KW - Humans
KW - Neurons/physiology
KW - Potassium Channels/chemistry
KW - Protein Subunits/chemistry
KW - Protein Transport/physiology
U2 - 10.1016/j.conb.2005.04.001
DO - 10.1016/j.conb.2005.04.001
M3 - SCORING: Review article
C2 - 15961040
VL - 15
SP - 364
EP - 369
JO - CURR OPIN NEUROBIOL
JF - CURR OPIN NEUROBIOL
SN - 0959-4388
IS - 3
ER -
