Toxicological and analytical investigations of noni (Morinda citrifolia) fruit juice.
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Toxicological and analytical investigations of noni (Morinda citrifolia) fruit juice. / Westendorf, Johannes; Harms-Effenberger, Katharina; Iznaguen, Hassan; Basar, Simla.
in: J AGR FOOD CHEM, Jahrgang 55, Nr. 2, 2, 2007, S. 529-537.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Toxicological and analytical investigations of noni (Morinda citrifolia) fruit juice.
AU - Westendorf, Johannes
AU - Harms-Effenberger, Katharina
AU - Iznaguen, Hassan
AU - Basar, Simla
PY - 2007
Y1 - 2007
N2 - Morinda citrifolia (noni) is known to contain genotoxic anthraquinones in the roots. Because of the widespread use of noni juice, the possible genotoxic risk was examined through a battery of short-term tests. Noni juice was also chemically analyzed for the possible presence of anthraquinones. Noni juice extract in the Salmonella microsome assay showed a slight mutagenic effect in strain TA1537, due to the presence of flavonoids. No mutagenicity was observed in the mammalian mutagenicity test with V79 Chinese hamster fibroblasts. Rats treated with a noni juice concentrate did not show DNA repair synthesis (UDS) in primary rat hepatocytes, nor could DNA adducts or DNA strand breaks be observed. HPLC analysis of noni juice for anthraquinones was negative, with a sensitivity of
AB - Morinda citrifolia (noni) is known to contain genotoxic anthraquinones in the roots. Because of the widespread use of noni juice, the possible genotoxic risk was examined through a battery of short-term tests. Noni juice was also chemically analyzed for the possible presence of anthraquinones. Noni juice extract in the Salmonella microsome assay showed a slight mutagenic effect in strain TA1537, due to the presence of flavonoids. No mutagenicity was observed in the mammalian mutagenicity test with V79 Chinese hamster fibroblasts. Rats treated with a noni juice concentrate did not show DNA repair synthesis (UDS) in primary rat hepatocytes, nor could DNA adducts or DNA strand breaks be observed. HPLC analysis of noni juice for anthraquinones was negative, with a sensitivity of
M3 - SCORING: Zeitschriftenaufsatz
VL - 55
SP - 529
EP - 537
JO - J AGR FOOD CHEM
JF - J AGR FOOD CHEM
SN - 0021-8561
IS - 2
M1 - 2
ER -
