Toxicity screening of mouthwashes in the pollen tube growth test: safety assessment of recommended dilutions.
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Toxicity screening of mouthwashes in the pollen tube growth test: safety assessment of recommended dilutions. / Kristen, Udo; Friedrich, Reinhard.
in: Braz Dent J, Jahrgang 17, Nr. 1, 1, 2006, S. 58-62.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Toxicity screening of mouthwashes in the pollen tube growth test: safety assessment of recommended dilutions.
AU - Kristen, Udo
AU - Friedrich, Reinhard
PY - 2006
Y1 - 2006
N2 - This study investigated whether mouthwash dilutions, recommended by the manufacturers, may contribute to oral mucosa irritation. Twenty frequently used mouthwash brands were examined by the pollen tube growth test, an alternative in vitro method for assessment of the irritating potential of ingredients of cosmetic formulations. The test is based on the photometric quantification of pollen tube growth inhibition. This parameter is expressed by IC50 values that characterize the cytotoxic potential of a product. The IC50s clearly revealed that none of the tested mouthwashes should cause acute irritation if used in the recommended dilution. However, at least 4 of the mouthwashes evaluated in this study could probably irritate the oral mucosa acutely if used undiluted (original concentration).
AB - This study investigated whether mouthwash dilutions, recommended by the manufacturers, may contribute to oral mucosa irritation. Twenty frequently used mouthwash brands were examined by the pollen tube growth test, an alternative in vitro method for assessment of the irritating potential of ingredients of cosmetic formulations. The test is based on the photometric quantification of pollen tube growth inhibition. This parameter is expressed by IC50 values that characterize the cytotoxic potential of a product. The IC50s clearly revealed that none of the tested mouthwashes should cause acute irritation if used in the recommended dilution. However, at least 4 of the mouthwashes evaluated in this study could probably irritate the oral mucosa acutely if used undiluted (original concentration).
U2 - 10.1590/s0103-64402006000100013
DO - 10.1590/s0103-64402006000100013
M3 - SCORING: Zeitschriftenaufsatz
VL - 17
SP - 58
EP - 62
IS - 1
M1 - 1
ER -
