Topographic abnormality of slow cortical potentials in schizophrenia.

TY - JOUR

T1 - Topographic abnormality of slow cortical potentials in schizophrenia.

AU - Basile, L F H

AU - Yacubian, Juliana

AU - Ferreira, B L C

AU - Valim, A C

AU - Gattaz, W F

PY - 2004

Y1 - 2004

N2 - A recent study from our laboratory has provided evidence for the generation of slow potentials occurring in anticipation to task-performance feedback stimuli, in multiple association cortical areas, consistently including two prefrontal areas. In the present study, we intended to determine whether these slow potentials would indicate some abnormality (topographic) in schizophrenic patients, and thus serve as an indication of abnormal association cortex activity. We recorded slow potentials while subjects performed a paired-associates memory task. A 123-channel EEG montage and common average reference were used for 20 unmedicated schizophrenic (mean duration of illness: 11.3 +/- 9.2 years; mean number of previous hospitalizations: 1.2 +/- 1.9) and 22 healthy control subjects during a visual paired-associates matching task. For the topographic analysis, we used a simple index of individual topographic deviation from normality, corrected for absolute potential intensities. Slow potentials were observed in all subjects. Control subjects showed a simple spatial pattern of voltage extrema (left central positive and right prefrontal negative), whereas schizophrenic patients presented a more complex, fragmented pattern. Topographic deviation was significantly different between groups (P

AB - A recent study from our laboratory has provided evidence for the generation of slow potentials occurring in anticipation to task-performance feedback stimuli, in multiple association cortical areas, consistently including two prefrontal areas. In the present study, we intended to determine whether these slow potentials would indicate some abnormality (topographic) in schizophrenic patients, and thus serve as an indication of abnormal association cortex activity. We recorded slow potentials while subjects performed a paired-associates memory task. A 123-channel EEG montage and common average reference were used for 20 unmedicated schizophrenic (mean duration of illness: 11.3 +/- 9.2 years; mean number of previous hospitalizations: 1.2 +/- 1.9) and 22 healthy control subjects during a visual paired-associates matching task. For the topographic analysis, we used a simple index of individual topographic deviation from normality, corrected for absolute potential intensities. Slow potentials were observed in all subjects. Control subjects showed a simple spatial pattern of voltage extrema (left central positive and right prefrontal negative), whereas schizophrenic patients presented a more complex, fragmented pattern. Topographic deviation was significantly different between groups (P

U2 - 10.1590/s0100-879x2004000100014

DO - 10.1590/s0100-879x2004000100014

M3 - SCORING: Zeitschriftenaufsatz

VL - 37

SP - 97

EP - 109

JO - BRAZ J MED BIOL RES

JF - BRAZ J MED BIOL RES

SN - 0100-879X

IS - 1

M1 - 1

ER -