Tissue-based molecular markers for renal cell carcinoma

TY - JOUR

T1 - Tissue-based molecular markers for renal cell carcinoma

AU - Rink, M

AU - Chun, F K H

AU - Robinson, B

AU - Sun, M

AU - Karakiewicz, P I

AU - Bensalah, K

AU - Fisch, M

AU - Scherr, D S

AU - Lee, R K

AU - Margulis, V

AU - Shariat, S F

PY - 2011/12

Y1 - 2011/12

N2 - Since the introduction of targeted therapies in renal cell carcinoma (RCC), more individualized treatment options have become available. Molecular markers might support treatment planning due to more accurate individual risk stratification. Current molecular markers in RCC were reviewed to elucidate clinical impact and future perspectives. An English-language literature review of the Medline database (1990 to September 2010) of published data on tissue-based molecular markers and RCC was undertaken. Histological types, clinical and oncological behaviour are variable in renal masses. Molecular markers offer potential for additional information in tumour detection and diagnosis, prognostic and predictive values, as well as determination of therapeutic targets. Investigations on molecular biomarkers in RCC include hypoxia inducible factor (HIF-?), vascular endothelial growth factor (VEGF), carbonic anhydrase IX (CAIX), mammalian target of rapamycin (mTOR), survivin, B7-H1, p53, matrix metalloproteinases (MMP), Insulin-like growth factor II mRNA-binding protein 3 (IMP3), Ki-67, C-reactive protein (CRP), Vimentin, Fascin, platelet count, hemoglobin level and combinations of these factors. Although some markers offer promising results, utilization in daily practice is compromised due to limited specificity, predictive accuracy and tumour histology variablity. There is an imminent need for novel molecular markers that allow accurate histologic and biologic classification of RCC to improve upon current outcomes. It is very likely that a panel of molecular markers will be used to achieve a sufficient degree of certainty in order to guide clinical decisions. A large concerted effort is required to advance the field of RCC molecular marker through systematic discovery, verification, and validation.

AB - Since the introduction of targeted therapies in renal cell carcinoma (RCC), more individualized treatment options have become available. Molecular markers might support treatment planning due to more accurate individual risk stratification. Current molecular markers in RCC were reviewed to elucidate clinical impact and future perspectives. An English-language literature review of the Medline database (1990 to September 2010) of published data on tissue-based molecular markers and RCC was undertaken. Histological types, clinical and oncological behaviour are variable in renal masses. Molecular markers offer potential for additional information in tumour detection and diagnosis, prognostic and predictive values, as well as determination of therapeutic targets. Investigations on molecular biomarkers in RCC include hypoxia inducible factor (HIF-?), vascular endothelial growth factor (VEGF), carbonic anhydrase IX (CAIX), mammalian target of rapamycin (mTOR), survivin, B7-H1, p53, matrix metalloproteinases (MMP), Insulin-like growth factor II mRNA-binding protein 3 (IMP3), Ki-67, C-reactive protein (CRP), Vimentin, Fascin, platelet count, hemoglobin level and combinations of these factors. Although some markers offer promising results, utilization in daily practice is compromised due to limited specificity, predictive accuracy and tumour histology variablity. There is an imminent need for novel molecular markers that allow accurate histologic and biologic classification of RCC to improve upon current outcomes. It is very likely that a panel of molecular markers will be used to achieve a sufficient degree of certainty in order to guide clinical decisions. A large concerted effort is required to advance the field of RCC molecular marker through systematic discovery, verification, and validation.

KW - B7-H1 Antigen

KW - Biomarkers, Tumor

KW - C-Reactive Protein

KW - Carbonic Anhydrases

KW - Carcinoma, Renal Cell

KW - Carrier Proteins

KW - Cysteine Proteinase Inhibitors

KW - Hemoglobins

KW - Humans

KW - Hypoxia-Inducible Factor 1, alpha Subunit

KW - Inhibitor of Apoptosis Proteins

KW - Insulin-Like Growth Factor II

KW - Ki-67 Antigen

KW - Kidney Neoplasms

KW - Matrix Metalloproteinase 1

KW - Microfilament Proteins

KW - Platelet Count

KW - Prognosis

KW - RNA-Binding Proteins

KW - TOR Serine-Threonine Kinases

KW - Tumor Suppressor Protein p53

KW - Vascular Endothelial Growth Factor A

KW - Vimentin

KW - Journal Article

KW - Review

M3 - SCORING: Review article

C2 - 21996985

VL - 63

SP - 293

EP - 308

JO - MINERVA UROL NEFROL

JF - MINERVA UROL NEFROL

SN - 0393-2249

IS - 4

M1 - 4

ER -