[Tissue microarrays. Value of immunohistochemical proliferation markers for serial investigations of head and neck cancer]
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[Tissue microarrays. Value of immunohistochemical proliferation markers for serial investigations of head and neck cancer]. / Peters, S; Hambek, M; Gstöttner, W; Knecht, Rainald.
in: HNO, Jahrgang 52, Nr. 5, 5, 2004, S. 409-412.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [Tissue microarrays. Value of immunohistochemical proliferation markers for serial investigations of head and neck cancer]
AU - Peters, S
AU - Hambek, M
AU - Gstöttner, W
AU - Knecht, Rainald
PY - 2004
Y1 - 2004
N2 - BACKGROUND: Tissue microarrays (TMAs) are still seldom used in oncological research, especially that involving otorhinolaryngology, although the benefit of this method has often been reported. METHODS: We prepared ten different tumor probes from patients with head and neck cancer for immunohistochemistry and performed ki67 and proliferating cell nuclear antigen (PCNA) staining on the usual paraffin sections as well as on TMAs consisting of the same tissue. RESULTS AND CONCLUSIONS: We conclude that investigation by means of TMA makes oncological research, and especially the screening of tumor probes, much more efficient since a high correlation ( r>0.7, P
AB - BACKGROUND: Tissue microarrays (TMAs) are still seldom used in oncological research, especially that involving otorhinolaryngology, although the benefit of this method has often been reported. METHODS: We prepared ten different tumor probes from patients with head and neck cancer for immunohistochemistry and performed ki67 and proliferating cell nuclear antigen (PCNA) staining on the usual paraffin sections as well as on TMAs consisting of the same tissue. RESULTS AND CONCLUSIONS: We conclude that investigation by means of TMA makes oncological research, and especially the screening of tumor probes, much more efficient since a high correlation ( r>0.7, P
M3 - SCORING: Zeitschriftenaufsatz
VL - 52
SP - 409
EP - 412
JO - HNO
JF - HNO
SN - 0017-6192
IS - 5
M1 - 5
ER -
