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Timing of reconstruction of the lower urinary tract in pediatric kidney transplant recipients: A CERTAIN multicenter analysis of current practice

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Timing of reconstruction of the lower urinary tract in pediatric kidney transplant recipients: A CERTAIN multicenter analysis of current practice. / Patry, Christian; Höcker, Britta; Dello Strologo, Luca; Baumann, Lukas; Grenda, Ryszard; Peruzzi, Licia; Oh, Jun; Pape, Lars; Weber, Lutz T; Weitz, Marcus; Awan, Atif; Carraro, Andrea; Zirngibl, Matthias; Hansen, Matthias; Müller, Dominik; Bald, Martin; Pecqueux, Carine; Krupka, Kai; Fichtner, Alexander; Tönshoff, Burkhard; Nyarangi-Dix, Joanne.

in: PEDIATR TRANSPLANT, Jahrgang 26, Nr. 6, e14328, 09.2022.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Patry, C, Höcker, B, Dello Strologo, L, Baumann, L, Grenda, R, Peruzzi, L, Oh, J, Pape, L, Weber, LT, Weitz, M, Awan, A, Carraro, A, Zirngibl, M, Hansen, M, Müller, D, Bald, M, Pecqueux, C, Krupka, K, Fichtner, A, Tönshoff, B & Nyarangi-Dix, J 2022, 'Timing of reconstruction of the lower urinary tract in pediatric kidney transplant recipients: A CERTAIN multicenter analysis of current practice', PEDIATR TRANSPLANT, Jg. 26, Nr. 6, e14328. https://doi.org/10.1111/petr.14328

APA

Patry, C., Höcker, B., Dello Strologo, L., Baumann, L., Grenda, R., Peruzzi, L., Oh, J., Pape, L., Weber, L. T., Weitz, M., Awan, A., Carraro, A., Zirngibl, M., Hansen, M., Müller, D., Bald, M., Pecqueux, C., Krupka, K., Fichtner, A., ... Nyarangi-Dix, J. (2022). Timing of reconstruction of the lower urinary tract in pediatric kidney transplant recipients: A CERTAIN multicenter analysis of current practice. PEDIATR TRANSPLANT, 26(6), [e14328]. https://doi.org/10.1111/petr.14328

Vancouver

Patry C, Höcker B, Dello Strologo L, Baumann L, Grenda R, Peruzzi L et al. Timing of reconstruction of the lower urinary tract in pediatric kidney transplant recipients: A CERTAIN multicenter analysis of current practice. PEDIATR TRANSPLANT. 2022 Sep;26(6). e14328. https://doi.org/10.1111/petr.14328

Bibtex

@article{c52991a5bc184a388d6eb67d7c37cc2c,
title = "Timing of reconstruction of the lower urinary tract in pediatric kidney transplant recipients: A CERTAIN multicenter analysis of current practice",
abstract = "BACKGROUND: Preexistent LUTD are considered a hostile environment, which might negatively impact KTx survival. In such cases, surgical reconstruction of the bladder is required. However, there is still disagreement on the optimal timing of the reconstruction procedure.METHODS: This is a multicenter analysis of data from the CERTAIN Registry. Included were 62 children aged 8.18 ± 4.90 years, with LUTD. Study endpoints were the duration of initial posttransplant hospitalization, febrile UTIs, and a composite failure endpoint comprising decline of eGFR, graft loss, or death up to 5 years posttransplant. Outcome was compared to matched controls without bladder dysfunction.RESULTS: Forty-one patients (66.1%) underwent pretransplant and 14 patients (22.6%) posttransplant reconstruction. Bladder augmentation was performed more frequently in the pretransplant (61%) than in the posttransplant group (21%, p = .013). Outcome in the pre- and posttransplant groups and in the subgroups of patients on pretransplant PD with major bladder surgery either pre- (n = 14) or posttransplant (n = 7) was comparable. Outcomes of the main study cohort and the matched control cohort (n = 119) were comparable during the first 4 years posttransplant; at year 5, there were more events of transplant dysfunction in the study cohort with LUTD than in controls (p = .03).CONCLUSIONS: This multicenter analysis of the current practice of LUTD reconstruction in pediatric KTx recipients shows that pre- or posttransplant surgical reconstruction of the lower urinary tract is associated with a comparable 5-year outcome.",
author = "Christian Patry and Britta H{\"o}cker and {Dello Strologo}, Luca and Lukas Baumann and Ryszard Grenda and Licia Peruzzi and Jun Oh and Lars Pape and Weber, {Lutz T} and Marcus Weitz and Atif Awan and Andrea Carraro and Matthias Zirngibl and Matthias Hansen and Dominik M{\"u}ller and Martin Bald and Carine Pecqueux and Kai Krupka and Alexander Fichtner and Burkhard T{\"o}nshoff and Joanne Nyarangi-Dix",
note = "{\textcopyright} 2022 The Authors. Pediatric Transplantation published by Wiley Periodicals LLC.",
year = "2022",
month = sep,
doi = "10.1111/petr.14328",
language = "English",
volume = "26",
journal = "PEDIATR TRANSPLANT",
issn = "1397-3142",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Timing of reconstruction of the lower urinary tract in pediatric kidney transplant recipients: A CERTAIN multicenter analysis of current practice

AU - Patry, Christian

AU - Höcker, Britta

AU - Dello Strologo, Luca

AU - Baumann, Lukas

AU - Grenda, Ryszard

AU - Peruzzi, Licia

AU - Oh, Jun

AU - Pape, Lars

AU - Weber, Lutz T

AU - Weitz, Marcus

AU - Awan, Atif

AU - Carraro, Andrea

AU - Zirngibl, Matthias

AU - Hansen, Matthias

AU - Müller, Dominik

AU - Bald, Martin

AU - Pecqueux, Carine

AU - Krupka, Kai

AU - Fichtner, Alexander

AU - Tönshoff, Burkhard

AU - Nyarangi-Dix, Joanne

N1 - © 2022 The Authors. Pediatric Transplantation published by Wiley Periodicals LLC.

PY - 2022/9

Y1 - 2022/9

N2 - BACKGROUND: Preexistent LUTD are considered a hostile environment, which might negatively impact KTx survival. In such cases, surgical reconstruction of the bladder is required. However, there is still disagreement on the optimal timing of the reconstruction procedure.METHODS: This is a multicenter analysis of data from the CERTAIN Registry. Included were 62 children aged 8.18 ± 4.90 years, with LUTD. Study endpoints were the duration of initial posttransplant hospitalization, febrile UTIs, and a composite failure endpoint comprising decline of eGFR, graft loss, or death up to 5 years posttransplant. Outcome was compared to matched controls without bladder dysfunction.RESULTS: Forty-one patients (66.1%) underwent pretransplant and 14 patients (22.6%) posttransplant reconstruction. Bladder augmentation was performed more frequently in the pretransplant (61%) than in the posttransplant group (21%, p = .013). Outcome in the pre- and posttransplant groups and in the subgroups of patients on pretransplant PD with major bladder surgery either pre- (n = 14) or posttransplant (n = 7) was comparable. Outcomes of the main study cohort and the matched control cohort (n = 119) were comparable during the first 4 years posttransplant; at year 5, there were more events of transplant dysfunction in the study cohort with LUTD than in controls (p = .03).CONCLUSIONS: This multicenter analysis of the current practice of LUTD reconstruction in pediatric KTx recipients shows that pre- or posttransplant surgical reconstruction of the lower urinary tract is associated with a comparable 5-year outcome.

AB - BACKGROUND: Preexistent LUTD are considered a hostile environment, which might negatively impact KTx survival. In such cases, surgical reconstruction of the bladder is required. However, there is still disagreement on the optimal timing of the reconstruction procedure.METHODS: This is a multicenter analysis of data from the CERTAIN Registry. Included were 62 children aged 8.18 ± 4.90 years, with LUTD. Study endpoints were the duration of initial posttransplant hospitalization, febrile UTIs, and a composite failure endpoint comprising decline of eGFR, graft loss, or death up to 5 years posttransplant. Outcome was compared to matched controls without bladder dysfunction.RESULTS: Forty-one patients (66.1%) underwent pretransplant and 14 patients (22.6%) posttransplant reconstruction. Bladder augmentation was performed more frequently in the pretransplant (61%) than in the posttransplant group (21%, p = .013). Outcome in the pre- and posttransplant groups and in the subgroups of patients on pretransplant PD with major bladder surgery either pre- (n = 14) or posttransplant (n = 7) was comparable. Outcomes of the main study cohort and the matched control cohort (n = 119) were comparable during the first 4 years posttransplant; at year 5, there were more events of transplant dysfunction in the study cohort with LUTD than in controls (p = .03).CONCLUSIONS: This multicenter analysis of the current practice of LUTD reconstruction in pediatric KTx recipients shows that pre- or posttransplant surgical reconstruction of the lower urinary tract is associated with a comparable 5-year outcome.

U2 - 10.1111/petr.14328

DO - 10.1111/petr.14328

M3 - SCORING: Journal article

C2 - 35689820

VL - 26

JO - PEDIATR TRANSPLANT

JF - PEDIATR TRANSPLANT

SN - 1397-3142

IS - 6

M1 - e14328

ER -