Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons.
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Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons. / Mayer, Christian; Acosta-Martinez, Maricedes; Dubois, Sharon L; Wolfe, Andrew; Radovick, Sally; Boehm, Ulrich; Levine, Jon E.
in: P NATL ACAD SCI USA, Jahrgang 107, Nr. 52, 52, 2010, S. 22693-22698.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons.
AU - Mayer, Christian
AU - Acosta-Martinez, Maricedes
AU - Dubois, Sharon L
AU - Wolfe, Andrew
AU - Radovick, Sally
AU - Boehm, Ulrich
AU - Levine, Jon E
PY - 2010
Y1 - 2010
N2 - Puberty onset is initiated by activation of neurons that secrete gonadotropin-releasing hormone (GnRH). The timing and progression of puberty may depend upon temporal coordination of two opposing central mechanisms--a restraint of GnRH secretion before puberty onset, followed by enhanced stimulation of GnRH release to complete reproductive maturation during puberty. Neuronal estrogen receptor (ER ) has been implicated in both controls; however, the underlying neural circuits are not well understood. Here we test whether these mechanisms are mediated by neurons that express kisspeptin, a neuropeptide that modulates GnRH neurosecretion. Strikingly, conditional ablation of ER in kisspeptin neurons results in a dramatic advancement of puberty onset in female mice. Furthermore, subsequent pubertal maturation is arrested in these animals, as they fail to acquire normal ovulatory cyclicity. We show that the temporal coordination of juvenile restraint and subsequent pubertal activation is likely mediated by ER in two separate kisspeptin neuronal populations in the hypothalamus.
AB - Puberty onset is initiated by activation of neurons that secrete gonadotropin-releasing hormone (GnRH). The timing and progression of puberty may depend upon temporal coordination of two opposing central mechanisms--a restraint of GnRH secretion before puberty onset, followed by enhanced stimulation of GnRH release to complete reproductive maturation during puberty. Neuronal estrogen receptor (ER ) has been implicated in both controls; however, the underlying neural circuits are not well understood. Here we test whether these mechanisms are mediated by neurons that express kisspeptin, a neuropeptide that modulates GnRH neurosecretion. Strikingly, conditional ablation of ER in kisspeptin neurons results in a dramatic advancement of puberty onset in female mice. Furthermore, subsequent pubertal maturation is arrested in these animals, as they fail to acquire normal ovulatory cyclicity. We show that the temporal coordination of juvenile restraint and subsequent pubertal activation is likely mediated by ER in two separate kisspeptin neuronal populations in the hypothalamus.
KW - Animals
KW - Male
KW - Female
KW - Immunohistochemistry
KW - Time Factors
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Models, Biological
KW - Signal Transduction
KW - Neurons metabolism
KW - Ovariectomy
KW - Estrogen Receptor alpha genetics
KW - Estrous Cycle
KW - Gonadotropin-Releasing Hormone secretion
KW - Luteinizing Hormone secretion
KW - Sexual Maturation physiology
KW - Tumor Suppressor Proteins genetics
KW - Animals
KW - Male
KW - Female
KW - Immunohistochemistry
KW - Time Factors
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Models, Biological
KW - Signal Transduction
KW - Neurons metabolism
KW - Ovariectomy
KW - Estrogen Receptor alpha genetics
KW - Estrous Cycle
KW - Gonadotropin-Releasing Hormone secretion
KW - Luteinizing Hormone secretion
KW - Sexual Maturation physiology
KW - Tumor Suppressor Proteins genetics
M3 - SCORING: Zeitschriftenaufsatz
VL - 107
SP - 22693
EP - 22698
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 52
M1 - 52
ER -
