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Time to remission from mild to moderate depressive symptoms. One year results from the EVIDENT-study, an RCT of an internet intervention for depression

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Time to remission from mild to moderate depressive symptoms. One year results from the EVIDENT-study, an RCT of an internet intervention for depression. / Klein, Jan Philipp; Späth, Christina; Schröder, Johanna; Meyer, Björn; Greiner, Wolfgang; Hautzinger, Martin; Lutz, Wolfgang; Rose, Matthias; Vettorazzi, Eik; Andersson, Gerhard; Hohagen, Fritz; Moritz, Steffen; Berger, Thomas.

in: BEHAV RES THER, Jahrgang 97, 10.2017, S. 154-162.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Klein, JP, Späth, C, Schröder, J, Meyer, B, Greiner, W, Hautzinger, M, Lutz, W, Rose, M, Vettorazzi, E, Andersson, G, Hohagen, F, Moritz, S & Berger, T 2017, 'Time to remission from mild to moderate depressive symptoms. One year results from the EVIDENT-study, an RCT of an internet intervention for depression', BEHAV RES THER, Jg. 97, S. 154-162. https://doi.org/10.1016/j.brat.2017.07.013

APA

Klein, J. P., Späth, C., Schröder, J., Meyer, B., Greiner, W., Hautzinger, M., Lutz, W., Rose, M., Vettorazzi, E., Andersson, G., Hohagen, F., Moritz, S., & Berger, T. (2017). Time to remission from mild to moderate depressive symptoms. One year results from the EVIDENT-study, an RCT of an internet intervention for depression. BEHAV RES THER, 97, 154-162. https://doi.org/10.1016/j.brat.2017.07.013

Vancouver

Klein JP, Späth C, Schröder J, Meyer B, Greiner W, Hautzinger M et al. Time to remission from mild to moderate depressive symptoms. One year results from the EVIDENT-study, an RCT of an internet intervention for depression. BEHAV RES THER. 2017 Okt;97:154-162. https://doi.org/10.1016/j.brat.2017.07.013

Bibtex

@article{03aa83ca683b46be8a9c18881ae58dc9,
title = "Time to remission from mild to moderate depressive symptoms. One year results from the EVIDENT-study, an RCT of an internet intervention for depression",
abstract = "BACKGROUND: Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period.METHODS: A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months.RESULTS: Remission rates over time were significantly higher in the intervention group (Cox regression: hazard ratio [HR] 1.31; p = 0.009). The intervention was more effective in the subgroup not taking antidepressant medication (Cox regression: HR 1.88; p < 0.001). PHQ-change from baseline was greater in the intervention group (linear mixed model [LMM]: p < 0.001) with the between-group effect gradually decreasing from d = 0.36 at three months to d = 0.13 at twelve months (LMM: group by time interaction: p < 0.001).CONCLUSION: This internet intervention can contribute to achieving remission in people with mild to moderate depressive symptoms, especially if they are not on antidepressant medication (Trial Registration: NCT01636752).",
keywords = "Journal Article",
author = "Klein, {Jan Philipp} and Christina Sp{\"a}th and Johanna Schr{\"o}der and Bj{\"o}rn Meyer and Wolfgang Greiner and Martin Hautzinger and Wolfgang Lutz and Matthias Rose and Eik Vettorazzi and Gerhard Andersson and Fritz Hohagen and Steffen Moritz and Thomas Berger",
note = "Copyright {\textcopyright} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = oct,
doi = "10.1016/j.brat.2017.07.013",
language = "English",
volume = "97",
pages = "154--162",
journal = "BEHAV RES THER",
issn = "0005-7967",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Time to remission from mild to moderate depressive symptoms. One year results from the EVIDENT-study, an RCT of an internet intervention for depression

AU - Klein, Jan Philipp

AU - Späth, Christina

AU - Schröder, Johanna

AU - Meyer, Björn

AU - Greiner, Wolfgang

AU - Hautzinger, Martin

AU - Lutz, Wolfgang

AU - Rose, Matthias

AU - Vettorazzi, Eik

AU - Andersson, Gerhard

AU - Hohagen, Fritz

AU - Moritz, Steffen

AU - Berger, Thomas

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/10

Y1 - 2017/10

N2 - BACKGROUND: Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period.METHODS: A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months.RESULTS: Remission rates over time were significantly higher in the intervention group (Cox regression: hazard ratio [HR] 1.31; p = 0.009). The intervention was more effective in the subgroup not taking antidepressant medication (Cox regression: HR 1.88; p < 0.001). PHQ-change from baseline was greater in the intervention group (linear mixed model [LMM]: p < 0.001) with the between-group effect gradually decreasing from d = 0.36 at three months to d = 0.13 at twelve months (LMM: group by time interaction: p < 0.001).CONCLUSION: This internet intervention can contribute to achieving remission in people with mild to moderate depressive symptoms, especially if they are not on antidepressant medication (Trial Registration: NCT01636752).

AB - BACKGROUND: Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period.METHODS: A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months.RESULTS: Remission rates over time were significantly higher in the intervention group (Cox regression: hazard ratio [HR] 1.31; p = 0.009). The intervention was more effective in the subgroup not taking antidepressant medication (Cox regression: HR 1.88; p < 0.001). PHQ-change from baseline was greater in the intervention group (linear mixed model [LMM]: p < 0.001) with the between-group effect gradually decreasing from d = 0.36 at three months to d = 0.13 at twelve months (LMM: group by time interaction: p < 0.001).CONCLUSION: This internet intervention can contribute to achieving remission in people with mild to moderate depressive symptoms, especially if they are not on antidepressant medication (Trial Registration: NCT01636752).

KW - Journal Article

U2 - 10.1016/j.brat.2017.07.013

DO - 10.1016/j.brat.2017.07.013

M3 - SCORING: Journal article

C2 - 28797829

VL - 97

SP - 154

EP - 162

JO - BEHAV RES THER

JF - BEHAV RES THER

SN - 0005-7967

ER -