Tight junctions and differentiation--a chicken or the egg question?
Standard
Tight junctions and differentiation--a chicken or the egg question? / Kirschner, Nina; Rosenthal, Rita; Günzel, Dorothee; Moll, Ingrid; Brandner, Johanna.
in: EXP DERMATOL, Jahrgang 21, Nr. 3, 3, 2012, S. 171-175.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Tight junctions and differentiation--a chicken or the egg question?
AU - Kirschner, Nina
AU - Rosenthal, Rita
AU - Günzel, Dorothee
AU - Moll, Ingrid
AU - Brandner, Johanna
PY - 2012
Y1 - 2012
N2 - Skin barrier function is indispensable to prevent the uncontrolled loss of water and solutes and to protect the body from external assaults. To fulfil this function, keratinocytes undergo a complex pathway of differentiation that terminates in the formation of the stratum corneum. Additionally, tight junctions (TJs), which are cell-cell junctions localized in the stratum granulosum, are involved in the barrier function of the skin. Important biological and clinical roles of TJs are strongly suggested by altered TJ protein levels and distribution in skin diseases like psoriasis, ichthyosis and atopic dermatitis. Because these skin diseases show alterations in differentiation and TJs, it was suggested that changes in TJs might simply be a consequence of altered differentiation. However, in this viewpoint, we like to argue that the situation is not as simple and depends on the specific microenvironment. We discuss three hypotheses regarding the interplay between TJs/TJ proteins and differentiation: (1) TJs/TJ proteins are influenced by differentiation, (2) differentiation is influenced by TJs/TJ proteins, and (3) TJs/TJ proteins and differentiation are independent of each other. In addition, the concept is introduced that both processes are going on at the same time, which means that while one specific TJ protein/barrier component might be influenced by differentiation, the other may influence differentiation.
AB - Skin barrier function is indispensable to prevent the uncontrolled loss of water and solutes and to protect the body from external assaults. To fulfil this function, keratinocytes undergo a complex pathway of differentiation that terminates in the formation of the stratum corneum. Additionally, tight junctions (TJs), which are cell-cell junctions localized in the stratum granulosum, are involved in the barrier function of the skin. Important biological and clinical roles of TJs are strongly suggested by altered TJ protein levels and distribution in skin diseases like psoriasis, ichthyosis and atopic dermatitis. Because these skin diseases show alterations in differentiation and TJs, it was suggested that changes in TJs might simply be a consequence of altered differentiation. However, in this viewpoint, we like to argue that the situation is not as simple and depends on the specific microenvironment. We discuss three hypotheses regarding the interplay between TJs/TJ proteins and differentiation: (1) TJs/TJ proteins are influenced by differentiation, (2) differentiation is influenced by TJs/TJ proteins, and (3) TJs/TJ proteins and differentiation are independent of each other. In addition, the concept is introduced that both processes are going on at the same time, which means that while one specific TJ protein/barrier component might be influenced by differentiation, the other may influence differentiation.
KW - Animals
KW - Humans
KW - Mice
KW - Cell Differentiation/physiology
KW - Membrane Proteins/metabolism
KW - Keratinocytes/cytology
KW - Skin/metabolism
KW - Tight Junctions/metabolism
KW - Animals
KW - Humans
KW - Mice
KW - Cell Differentiation/physiology
KW - Membrane Proteins/metabolism
KW - Keratinocytes/cytology
KW - Skin/metabolism
KW - Tight Junctions/metabolism
M3 - SCORING: Journal article
VL - 21
SP - 171
EP - 175
JO - EXP DERMATOL
JF - EXP DERMATOL
SN - 0906-6705
IS - 3
M1 - 3
ER -
