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Thymus and myasthenia gravis: antigen processing in the human thymus and the consequences for the generation of autoreactive T cells

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Thymus and myasthenia gravis: antigen processing in the human thymus and the consequences for the generation of autoreactive T cells. / Melms, A; Luther, C; Stoeckle, C; Pöschel, S; Schroth, P; Varga, M; Wienhold, W; Tolosa, E.

in: ACTA NEUROL SCAND, Jahrgang 113, Nr. s183, 01.01.2006, S. 12-13.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Andere (Vorworte u.ä.) › Forschung

Harvard

Melms, A, Luther, C, Stoeckle, C, Pöschel, S, Schroth, P, Varga, M, Wienhold, W & Tolosa, E 2006, 'Thymus and myasthenia gravis: antigen processing in the human thymus and the consequences for the generation of autoreactive T cells', ACTA NEUROL SCAND, Jg. 113, Nr. s183, S. 12-13. https://doi.org/10.1111/j.1600-0404.2006.00636.x

APA

Melms, A., Luther, C., Stoeckle, C., Pöschel, S., Schroth, P., Varga, M., Wienhold, W., & Tolosa, E. (2006). Thymus and myasthenia gravis: antigen processing in the human thymus and the consequences for the generation of autoreactive T cells. ACTA NEUROL SCAND, 113(s183), 12-13. https://doi.org/10.1111/j.1600-0404.2006.00636.x

Vancouver

Melms A, Luther C, Stoeckle C, Pöschel S, Schroth P, Varga M et al. Thymus and myasthenia gravis: antigen processing in the human thymus and the consequences for the generation of autoreactive T cells. ACTA NEUROL SCAND. 2006 Jan 1;113(s183):12-13. https://doi.org/10.1111/j.1600-0404.2006.00636.x

Bibtex

@article{0bc13ccddd9f43848a32f4ba2acdb8b6,
title = "Thymus and myasthenia gravis: antigen processing in the human thymus and the consequences for the generation of autoreactive T cells",
abstract = "Peptides displayed by antigen presenting cells in the thymus shape the T cell repertoire. We investigated the antigen processing machinery of the MHC class II presentation pathway and describe the differential expression of lysosomal proteases in compartments of the thymus and the peripheral lymphoid tissue. Overexpression of certain proteases found in the thymus and thymoma associated with myasthenia gravis is likely to affect tolerance induction and may promote the generation autoreactive CD4(+) T helper cells.",
keywords = "Antigen-Presenting Cells, CD4-Positive T-Lymphocytes, Cathepsins, Cysteine Endopeptidases, Histocompatibility Antigens Class II, Humans, Myasthenia Gravis, Thymus Gland",
author = "A Melms and C Luther and C Stoeckle and S P{\"o}schel and P Schroth and M Varga and W Wienhold and E Tolosa",
year = "2006",
month = jan,
day = "1",
doi = "10.1111/j.1600-0404.2006.00636.x",
language = "English",
volume = "113",
pages = "12--13",
journal = "ACTA NEUROL SCAND",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "s183",

}

RIS

TY - JOUR

T1 - Thymus and myasthenia gravis: antigen processing in the human thymus and the consequences for the generation of autoreactive T cells

AU - Melms, A

AU - Luther, C

AU - Stoeckle, C

AU - Pöschel, S

AU - Schroth, P

AU - Varga, M

AU - Wienhold, W

AU - Tolosa, E

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Peptides displayed by antigen presenting cells in the thymus shape the T cell repertoire. We investigated the antigen processing machinery of the MHC class II presentation pathway and describe the differential expression of lysosomal proteases in compartments of the thymus and the peripheral lymphoid tissue. Overexpression of certain proteases found in the thymus and thymoma associated with myasthenia gravis is likely to affect tolerance induction and may promote the generation autoreactive CD4(+) T helper cells.

AB - Peptides displayed by antigen presenting cells in the thymus shape the T cell repertoire. We investigated the antigen processing machinery of the MHC class II presentation pathway and describe the differential expression of lysosomal proteases in compartments of the thymus and the peripheral lymphoid tissue. Overexpression of certain proteases found in the thymus and thymoma associated with myasthenia gravis is likely to affect tolerance induction and may promote the generation autoreactive CD4(+) T helper cells.

KW - Antigen-Presenting Cells

KW - CD4-Positive T-Lymphocytes

KW - Cathepsins

KW - Cysteine Endopeptidases

KW - Histocompatibility Antigens Class II

KW - Humans

KW - Myasthenia Gravis

KW - Thymus Gland

U2 - 10.1111/j.1600-0404.2006.00636.x

DO - 10.1111/j.1600-0404.2006.00636.x

M3 - Other (editorial matter etc.)

C2 - 16637920

VL - 113

SP - 12

EP - 13

JO - ACTA NEUROL SCAND

JF - ACTA NEUROL SCAND

SN - 0001-6314

IS - s183

ER -