Thrombotic thrombocytopenia After Sinopharm BBIBP-CorV COVID-19 vaccination
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Thrombotic thrombocytopenia After Sinopharm BBIBP-CorV COVID-19 vaccination. / Hosseinzadeh, Rezvan; Barary, Mohammad; Mehdinezhad, Hamed; Sio, Terence T; Langer, Florian; Khosravi, Sahar.
in: RES PRACT THROMB HAE, Jahrgang 6, Nr. 4, e12750, 05.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Thrombotic thrombocytopenia After Sinopharm BBIBP-CorV COVID-19 vaccination
AU - Hosseinzadeh, Rezvan
AU - Barary, Mohammad
AU - Mehdinezhad, Hamed
AU - Sio, Terence T
AU - Langer, Florian
AU - Khosravi, Sahar
N1 - © 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH).
PY - 2022/5
Y1 - 2022/5
N2 - Background: Severe side effects after vaccination with coronavirus disease 2019 (COVID-19) vaccines are rare but can be fatal. To date, vaccine-induced immune thrombotic thrombocytopenia (VITT) cases have been reported after injection of mRNA and adenoviral vectors COVID-19 vaccines. Here, we report the second suspected case of VITT after vaccination with the Sinopharm vaccine, an inactive vaccine.Key Clinical Question: The Key Clinical Question was to determine whether inactivated COVID-19 vaccines could induce VITT and how to diagnose and treat such cases.Clinical Approach and Conclusions: Our patient developed deteriorating symptoms the day after vaccination and was admitted to the emergency department on day 5 after vaccination. After performing laboratory analysis, thrombosis with thrombocytopenia was suggested, further confirmed by highly positive anti-heparin-platelet factor 4 antibodies assay and color Doppler ultrasonography. He was then treated with high-dose intravenous immunoglobulin, corticosteroid, and nonheparin anticoagulant.
AB - Background: Severe side effects after vaccination with coronavirus disease 2019 (COVID-19) vaccines are rare but can be fatal. To date, vaccine-induced immune thrombotic thrombocytopenia (VITT) cases have been reported after injection of mRNA and adenoviral vectors COVID-19 vaccines. Here, we report the second suspected case of VITT after vaccination with the Sinopharm vaccine, an inactive vaccine.Key Clinical Question: The Key Clinical Question was to determine whether inactivated COVID-19 vaccines could induce VITT and how to diagnose and treat such cases.Clinical Approach and Conclusions: Our patient developed deteriorating symptoms the day after vaccination and was admitted to the emergency department on day 5 after vaccination. After performing laboratory analysis, thrombosis with thrombocytopenia was suggested, further confirmed by highly positive anti-heparin-platelet factor 4 antibodies assay and color Doppler ultrasonography. He was then treated with high-dose intravenous immunoglobulin, corticosteroid, and nonheparin anticoagulant.
U2 - 10.1002/rth2.12750
DO - 10.1002/rth2.12750
M3 - SCORING: Journal article
C2 - 35769629
VL - 6
JO - RES PRACT THROMB HAE
JF - RES PRACT THROMB HAE
SN - 2475-0379
IS - 4
M1 - e12750
ER -