The ubiquitin-proteasome system in cardiomyopathies.
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The ubiquitin-proteasome system in cardiomyopathies. / Schlossarek, Saskia; Carrier, Lucie.
in: CURR OPIN CARDIOL, Jahrgang 26, Nr. 3, 3, 2011, S. 190-195.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The ubiquitin-proteasome system in cardiomyopathies.
AU - Schlossarek, Saskia
AU - Carrier, Lucie
PY - 2011
Y1 - 2011
N2 - Fine equilibrium between protein synthesis and protein degradation is essential for cell survival and function. After initial synthesis, membrane and secretory proteins are modified, folded, and assembled in the endoplasmic reticulum, whereas other proteins are synthesized and processed in the cytosol. Proteins are subject to different quality control systems to minimize aberrant production that could lead to cellular damage. The molecular chaperones help protein folding and stabilization, whereas the ubiquitin-proteasome system (UPS) and lysosomes degrade proteins. The UPS has been increasingly recognized as a major system involved in several biological processes such as cell proliferation, adaptation to stress and cell death.
AB - Fine equilibrium between protein synthesis and protein degradation is essential for cell survival and function. After initial synthesis, membrane and secretory proteins are modified, folded, and assembled in the endoplasmic reticulum, whereas other proteins are synthesized and processed in the cytosol. Proteins are subject to different quality control systems to minimize aberrant production that could lead to cellular damage. The molecular chaperones help protein folding and stabilization, whereas the ubiquitin-proteasome system (UPS) and lysosomes degrade proteins. The UPS has been increasingly recognized as a major system involved in several biological processes such as cell proliferation, adaptation to stress and cell death.
KW - Humans
KW - Cardiomegaly/pathology
KW - Endoplasmic Reticulum
KW - Heart Failure/pathology
KW - Molecular Chaperones/metabolism/physiology
KW - Myocardial Ischemia/pathology
KW - Myocytes, Cardiac/pathology
KW - Proteasome Endopeptidase Complex/metabolism/physiology
KW - Protein Folding
KW - Ubiquitin/metabolism/physiology
KW - Humans
KW - Cardiomegaly/pathology
KW - Endoplasmic Reticulum
KW - Heart Failure/pathology
KW - Molecular Chaperones/metabolism/physiology
KW - Myocardial Ischemia/pathology
KW - Myocytes, Cardiac/pathology
KW - Proteasome Endopeptidase Complex/metabolism/physiology
KW - Protein Folding
KW - Ubiquitin/metabolism/physiology
M3 - SCORING: Journal article
VL - 26
SP - 190
EP - 195
JO - CURR OPIN CARDIOL
JF - CURR OPIN CARDIOL
SN - 0268-4705
IS - 3
M1 - 3
ER -
