The ubiquitin-proteasome system: A potential therapeutic target for heart failure
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The ubiquitin-proteasome system: A potential therapeutic target for heart failure. / Barac, Yaron D; Emrich, Fabian; Krutzwakd-Josefson, Efrat; Schrepfer, Sonja; Sampaio, Luiz C; Willerson, James T; Robbins, Robert C; Ciechanover, Aaron; Mohr, Friedrich-Wilhelm; Aravot, Dan; Taylor, Doris A.
in: J HEART LUNG TRANSPL, Jahrgang 36, Nr. 7, 07.2017, S. 708-714.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - The ubiquitin-proteasome system: A potential therapeutic target for heart failure
AU - Barac, Yaron D
AU - Emrich, Fabian
AU - Krutzwakd-Josefson, Efrat
AU - Schrepfer, Sonja
AU - Sampaio, Luiz C
AU - Willerson, James T
AU - Robbins, Robert C
AU - Ciechanover, Aaron
AU - Mohr, Friedrich-Wilhelm
AU - Aravot, Dan
AU - Taylor, Doris A
N1 - Copyright © 2017 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
PY - 2017/7
Y1 - 2017/7
N2 - The rising incidence of heart failure (HF) is one of the biggest challenges in cardiovascular medicine. The persistent shortage of donor organs for transplantation has led to an expanding application of left ventricular assist devices as a bridge to recovery. Accumulating evidence suggests that the ubiquitin-proteasome system (UPS), which is responsible for protein degradation, plays a direct role in cardiac hypertrophy and HF and is impacted by mechanical unloading. The UPS system also plays a role in the cardiac regulation of apoptosis, cell mass, and sarcomere quality control. Furthermore, it is a key regulator of β2-adrenergic signaling, cell excitability, and conductance. In this review, we discuss the roles of the UPS in cardiac health and disease, including its roles in the pathologic hypertrophy associated with HF and its reversal during mechanical unloading. Finally, we suggest future areas of research, including possible therapeutic strategies for reversing cardiac remodeling by targeting the UPS.
AB - The rising incidence of heart failure (HF) is one of the biggest challenges in cardiovascular medicine. The persistent shortage of donor organs for transplantation has led to an expanding application of left ventricular assist devices as a bridge to recovery. Accumulating evidence suggests that the ubiquitin-proteasome system (UPS), which is responsible for protein degradation, plays a direct role in cardiac hypertrophy and HF and is impacted by mechanical unloading. The UPS system also plays a role in the cardiac regulation of apoptosis, cell mass, and sarcomere quality control. Furthermore, it is a key regulator of β2-adrenergic signaling, cell excitability, and conductance. In this review, we discuss the roles of the UPS in cardiac health and disease, including its roles in the pathologic hypertrophy associated with HF and its reversal during mechanical unloading. Finally, we suggest future areas of research, including possible therapeutic strategies for reversing cardiac remodeling by targeting the UPS.
KW - Heart Failure/etiology
KW - Humans
KW - Proteasome Endopeptidase Complex/physiology
KW - Signal Transduction
KW - Ubiquitin/physiology
KW - Ventricular Remodeling
U2 - 10.1016/j.healun.2017.02.012
DO - 10.1016/j.healun.2017.02.012
M3 - SCORING: Review article
C2 - 28341100
VL - 36
SP - 708
EP - 714
JO - J HEART LUNG TRANSPL
JF - J HEART LUNG TRANSPL
SN - 1053-2498
IS - 7
ER -
