The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy

Leon Dinshaw; Julia Münch; Jannis Dickow; Susanne Lezius; Stephan Willems; Boris A Hoffmann; Monica Patten

doi:10.1007/s00392-017-1164-4

The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy

Standard

The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy. / Dinshaw, Leon; Münch, Julia; Dickow, Jannis; Lezius, Susanne; Willems, Stephan; Hoffmann, Boris A; Patten, Monica.

in: CLIN RES CARDIOL, Jahrgang 107, Nr. 2, 02.2018, S. 130-137.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dinshaw, L, Münch, J, Dickow, J, Lezius, S, Willems, S, Hoffmann, BA & Patten, M 2018, 'The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy', CLIN RES CARDIOL, Jg. 107, Nr. 2, S. 130-137. https://doi.org/10.1007/s00392-017-1164-4

APA

Dinshaw, L., Münch, J., Dickow, J., Lezius, S., Willems, S., Hoffmann, B. A., & Patten, M. (2018). The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy. CLIN RES CARDIOL, 107(2), 130-137. https://doi.org/10.1007/s00392-017-1164-4

Vancouver

Dinshaw L, Münch J, Dickow J, Lezius S, Willems S, Hoffmann BA et al. The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy. CLIN RES CARDIOL. 2018 Feb;107(2):130-137. https://doi.org/10.1007/s00392-017-1164-4

Bibtex

@article{9130737aa1be485cbe6d6f4e97d87272,

title = "The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy",

abstract = "INTRODUCTION: Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of sudden cardiac death (SCD) primarily due to ventricular arrhythmia (VA). In patients (pts.) with a high risk of SCD, the implantation of an intracardiac cardioverter defibrillator (ICD) is thus indicated. Previous studies suggest that a prolonged interval between the peak and the end of the T wave, T-peak to T-end (TpTe), is associated with an elevated risk of VA and SCD in various clinical settings. The aim of our study was to evaluate the association between TpTe and VA in HCM pts. with a previously implanted ICD.METHODS: In 40 HCM pts. (51.4 ± 16.4 years; 62.5% men), TpTe was measured using the baseline digital standard resting 12-lead ECG during sinus rhythm. VA was assessed by device follow-up.RESULTS: Within 41.8 ± 35.1 months, 7 (17.5%) pts. had VA leading to appropriate therapy (AT), 7 pts. (17.5%) had non-sustained VA, and 26 pts. (65.0%) had no VA. The maximum TpTe was significantly prolonged in pts. with VA leading to AT compared to pts. without VA (101.3 ± 19.6 vs. 79.9 ± 15.3 ms; p = 0.004). Maximum TpTe was associated with an elevated risk of VA leading to AT (hazard ratio per 10 ms increase 1.63; 95% CI 1.04-2.54; p = 0.031) and pts. with a maximum TpTe ≤ 78 ms were without any VA leading to AT during follow-up. There was no correlation of maximum TpTe to other clinical parameters in our patient cohort.CONCLUSION: A prolonged TpTe is associated with VA and AT in HCM. Our findings suggest that TpTe can possibly serve as a marker for ventricular arrhythmogenesis in pts. with HCM and assessment of TpTe might, therefore, optimize SCD risk stratification.",

keywords = "Action Potentials, Adult, Aged, Arrhythmias, Cardiac, Cardiomyopathy, Hypertrophic, Death, Sudden, Cardiac, Defibrillators, Implantable, Disease-Free Survival, Echocardiography, Electric Countershock, Electrocardiography, Female, Heart Conduction System, Heart Rate, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Predictive Value of Tests, Proportional Hazards Models, Retrospective Studies, Risk Factors, Signal Processing, Computer-Assisted, Time Factors, Treatment Outcome, Journal Article",

author = "Leon Dinshaw and Julia M{\"u}nch and Jannis Dickow and Susanne Lezius and Stephan Willems and Hoffmann, {Boris A} and Monica Patten",

year = "2018",

month = feb,

doi = "10.1007/s00392-017-1164-4",

language = "English",

volume = "107",

pages = "130--137",

journal = "CLIN RES CARDIOL",

issn = "1861-0684",

publisher = "D. Steinkopff-Verlag",

number = "2",

}

RIS

TY - JOUR

T1 - The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy

AU - Dinshaw, Leon

AU - Münch, Julia

AU - Dickow, Jannis

AU - Lezius, Susanne

AU - Willems, Stephan

AU - Hoffmann, Boris A

AU - Patten, Monica

PY - 2018/2

Y1 - 2018/2

N2 - INTRODUCTION: Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of sudden cardiac death (SCD) primarily due to ventricular arrhythmia (VA). In patients (pts.) with a high risk of SCD, the implantation of an intracardiac cardioverter defibrillator (ICD) is thus indicated. Previous studies suggest that a prolonged interval between the peak and the end of the T wave, T-peak to T-end (TpTe), is associated with an elevated risk of VA and SCD in various clinical settings. The aim of our study was to evaluate the association between TpTe and VA in HCM pts. with a previously implanted ICD.METHODS: In 40 HCM pts. (51.4 ± 16.4 years; 62.5% men), TpTe was measured using the baseline digital standard resting 12-lead ECG during sinus rhythm. VA was assessed by device follow-up.RESULTS: Within 41.8 ± 35.1 months, 7 (17.5%) pts. had VA leading to appropriate therapy (AT), 7 pts. (17.5%) had non-sustained VA, and 26 pts. (65.0%) had no VA. The maximum TpTe was significantly prolonged in pts. with VA leading to AT compared to pts. without VA (101.3 ± 19.6 vs. 79.9 ± 15.3 ms; p = 0.004). Maximum TpTe was associated with an elevated risk of VA leading to AT (hazard ratio per 10 ms increase 1.63; 95% CI 1.04-2.54; p = 0.031) and pts. with a maximum TpTe ≤ 78 ms were without any VA leading to AT during follow-up. There was no correlation of maximum TpTe to other clinical parameters in our patient cohort.CONCLUSION: A prolonged TpTe is associated with VA and AT in HCM. Our findings suggest that TpTe can possibly serve as a marker for ventricular arrhythmogenesis in pts. with HCM and assessment of TpTe might, therefore, optimize SCD risk stratification.

AB - INTRODUCTION: Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of sudden cardiac death (SCD) primarily due to ventricular arrhythmia (VA). In patients (pts.) with a high risk of SCD, the implantation of an intracardiac cardioverter defibrillator (ICD) is thus indicated. Previous studies suggest that a prolonged interval between the peak and the end of the T wave, T-peak to T-end (TpTe), is associated with an elevated risk of VA and SCD in various clinical settings. The aim of our study was to evaluate the association between TpTe and VA in HCM pts. with a previously implanted ICD.METHODS: In 40 HCM pts. (51.4 ± 16.4 years; 62.5% men), TpTe was measured using the baseline digital standard resting 12-lead ECG during sinus rhythm. VA was assessed by device follow-up.RESULTS: Within 41.8 ± 35.1 months, 7 (17.5%) pts. had VA leading to appropriate therapy (AT), 7 pts. (17.5%) had non-sustained VA, and 26 pts. (65.0%) had no VA. The maximum TpTe was significantly prolonged in pts. with VA leading to AT compared to pts. without VA (101.3 ± 19.6 vs. 79.9 ± 15.3 ms; p = 0.004). Maximum TpTe was associated with an elevated risk of VA leading to AT (hazard ratio per 10 ms increase 1.63; 95% CI 1.04-2.54; p = 0.031) and pts. with a maximum TpTe ≤ 78 ms were without any VA leading to AT during follow-up. There was no correlation of maximum TpTe to other clinical parameters in our patient cohort.CONCLUSION: A prolonged TpTe is associated with VA and AT in HCM. Our findings suggest that TpTe can possibly serve as a marker for ventricular arrhythmogenesis in pts. with HCM and assessment of TpTe might, therefore, optimize SCD risk stratification.

KW - Action Potentials

KW - Adult

KW - Aged

KW - Arrhythmias, Cardiac

KW - Cardiomyopathy, Hypertrophic

KW - Death, Sudden, Cardiac

KW - Defibrillators, Implantable

KW - Disease-Free Survival

KW - Echocardiography

KW - Electric Countershock

KW - Electrocardiography

KW - Female

KW - Heart Conduction System

KW - Heart Rate

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Risk Factors

KW - Signal Processing, Computer-Assisted

KW - Time Factors

KW - Treatment Outcome

KW - Journal Article

U2 - 10.1007/s00392-017-1164-4

DO - 10.1007/s00392-017-1164-4

M3 - SCORING: Journal article

C2 - 28965260

VL - 107

SP - 130

EP - 137

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 2

ER -