PortalPublikationenThe Third DANish Study of Optimal Acute Treatment of Patient...

The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: Ischemic postconditioning or deferred stent implantation versus conventional primary angioplasty and complete revascularization versus treatment of culprit lesion only: Rationale and design of the DANAMI 3 trial program

Standard

The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: Ischemic postconditioning or deferred stent implantation versus conventional primary angioplasty and complete revascularization versus treatment of culprit lesion only: Rationale and design of the DANAMI 3 trial program. / Høfsten, Dan Eik; Kelbæk, Henning; Helqvist, Steffen; Kløvgaard, Lene; Holmvang, Lene; Clemmensen, Peter; Torp-Pedersen, Christian; Tilsted, Hans-Henrik; Bøtker, Hans Erik; Jensen, Lisette Okkels; Køber, Lars; Engstrøm, Thomas; DANAMI-3 Investigators.

in: AM HEART J, Jahrgang 169, Nr. 5, 05.2015, S. 613-621.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Høfsten, DE, Kelbæk, H, Helqvist, S, Kløvgaard, L, Holmvang, L, Clemmensen, P, Torp-Pedersen, C, Tilsted, H-H, Bøtker, HE, Jensen, LO, Køber, L, Engstrøm, T & DANAMI-3 Investigators 2015, 'The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: Ischemic postconditioning or deferred stent implantation versus conventional primary angioplasty and complete revascularization versus treatment of culprit lesion only: Rationale and design of the DANAMI 3 trial program', AM HEART J, Jg. 169, Nr. 5, S. 613-621. https://doi.org/10.1016/j.ahj.2015.02.004

APA

Høfsten, D. E., Kelbæk, H., Helqvist, S., Kløvgaard, L., Holmvang, L., Clemmensen, P., Torp-Pedersen, C., Tilsted, H-H., Bøtker, H. E., Jensen, L. O., Køber, L., Engstrøm, T., & DANAMI-3 Investigators (2015). The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: Ischemic postconditioning or deferred stent implantation versus conventional primary angioplasty and complete revascularization versus treatment of culprit lesion only: Rationale and design of the DANAMI 3 trial program. AM HEART J, 169(5), 613-621. https://doi.org/10.1016/j.ahj.2015.02.004

Vancouver

Høfsten DE, Kelbæk H, Helqvist S, Kløvgaard L, Holmvang L, Clemmensen P et al. The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: Ischemic postconditioning or deferred stent implantation versus conventional primary angioplasty and complete revascularization versus treatment of culprit lesion only: Rationale and design of the DANAMI 3 trial program. AM HEART J. 2015 Mai;169(5):613-621. https://doi.org/10.1016/j.ahj.2015.02.004

Bibtex

@article{5e0c1bb2d15c4cdcb15fabe0edd8b805,
title = "The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: Ischemic postconditioning or deferred stent implantation versus conventional primary angioplasty and complete revascularization versus treatment of culprit lesion only: Rationale and design of the DANAMI 3 trial program",
abstract = "BACKGROUND: In patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction, ischemic postconditioning has been shown to reduce infarct size, but the effect on clinical outcome has not been tested in a large randomized trial. In addition, deferring stent implantation in the infarct-related lesion 1 to 3 days after acute opening of the infarct-related artery could have protective effects, by reducing the risk of injury caused by distal embolization and microvascular obstruction. Finally, a considerable fraction of patients present with lesions in other coronary artery branches than the infarct-related artery. Whether a strategy of complete or partial revascularization of these patients should be preferred remains uncertain.STUDY DESIGN: The DANAMI 3 trial program was designed to investigate 3 different randomized treatment strategies in patients with ST-segment elevation myocardial infarction: (1) ischemic postconditioning versus conventional treatment with a primary end point of death and hospitalization for heart failure; (2) deferring stent implantation in the infarct-related lesion versus conventional treatment with a primary end point of death, hospitalization for heart failure, reinfarction, and repeat revascularization; and (3) treatment of the culprit lesion only versus fractional flow reserve-guided complete revascularization in patients with multivessel disease, with a primary end point of death, reinfarction, and repeat revascularization.SUMMARY: The DANAMI 3 trial program will determine whether either of 2 approaches to reduce reperfusion injury and distal microvascular obstruction with postconditioning or deferred stent implantation will translate into improved clinical outcome and whether patients with multivessel disease undergoing primary percutaneous coronary intervention will benefit from a strategy of complete or partial revascularization.",
keywords = "Adult, Angioplasty, Balloon, Coronary, Heart Failure/etiology, Hospitalization, Humans, Ischemic Postconditioning, Myocardial Infarction/complications, Recurrence, Research Design, Stents",
author = "H{\o}fsten, {Dan Eik} and Henning Kelb{\ae}k and Steffen Helqvist and Lene Kl{\o}vgaard and Lene Holmvang and Peter Clemmensen and Christian Torp-Pedersen and Hans-Henrik Tilsted and B{\o}tker, {Hans Erik} and Jensen, {Lisette Okkels} and Lars K{\o}ber and Thomas Engstr{\o}m and {DANAMI-3 Investigators}",
note = "Copyright {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = may,
doi = "10.1016/j.ahj.2015.02.004",
language = "English",
volume = "169",
pages = "613--621",
journal = "AM HEART J",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: Ischemic postconditioning or deferred stent implantation versus conventional primary angioplasty and complete revascularization versus treatment of culprit lesion only: Rationale and design of the DANAMI 3 trial program

AU - Høfsten, Dan Eik

AU - Kelbæk, Henning

AU - Helqvist, Steffen

AU - Kløvgaard, Lene

AU - Holmvang, Lene

AU - Clemmensen, Peter

AU - Torp-Pedersen, Christian

AU - Tilsted, Hans-Henrik

AU - Bøtker, Hans Erik

AU - Jensen, Lisette Okkels

AU - Køber, Lars

AU - Engstrøm, Thomas

AU - DANAMI-3 Investigators

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/5

Y1 - 2015/5

N2 - BACKGROUND: In patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction, ischemic postconditioning has been shown to reduce infarct size, but the effect on clinical outcome has not been tested in a large randomized trial. In addition, deferring stent implantation in the infarct-related lesion 1 to 3 days after acute opening of the infarct-related artery could have protective effects, by reducing the risk of injury caused by distal embolization and microvascular obstruction. Finally, a considerable fraction of patients present with lesions in other coronary artery branches than the infarct-related artery. Whether a strategy of complete or partial revascularization of these patients should be preferred remains uncertain.STUDY DESIGN: The DANAMI 3 trial program was designed to investigate 3 different randomized treatment strategies in patients with ST-segment elevation myocardial infarction: (1) ischemic postconditioning versus conventional treatment with a primary end point of death and hospitalization for heart failure; (2) deferring stent implantation in the infarct-related lesion versus conventional treatment with a primary end point of death, hospitalization for heart failure, reinfarction, and repeat revascularization; and (3) treatment of the culprit lesion only versus fractional flow reserve-guided complete revascularization in patients with multivessel disease, with a primary end point of death, reinfarction, and repeat revascularization.SUMMARY: The DANAMI 3 trial program will determine whether either of 2 approaches to reduce reperfusion injury and distal microvascular obstruction with postconditioning or deferred stent implantation will translate into improved clinical outcome and whether patients with multivessel disease undergoing primary percutaneous coronary intervention will benefit from a strategy of complete or partial revascularization.

AB - BACKGROUND: In patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction, ischemic postconditioning has been shown to reduce infarct size, but the effect on clinical outcome has not been tested in a large randomized trial. In addition, deferring stent implantation in the infarct-related lesion 1 to 3 days after acute opening of the infarct-related artery could have protective effects, by reducing the risk of injury caused by distal embolization and microvascular obstruction. Finally, a considerable fraction of patients present with lesions in other coronary artery branches than the infarct-related artery. Whether a strategy of complete or partial revascularization of these patients should be preferred remains uncertain.STUDY DESIGN: The DANAMI 3 trial program was designed to investigate 3 different randomized treatment strategies in patients with ST-segment elevation myocardial infarction: (1) ischemic postconditioning versus conventional treatment with a primary end point of death and hospitalization for heart failure; (2) deferring stent implantation in the infarct-related lesion versus conventional treatment with a primary end point of death, hospitalization for heart failure, reinfarction, and repeat revascularization; and (3) treatment of the culprit lesion only versus fractional flow reserve-guided complete revascularization in patients with multivessel disease, with a primary end point of death, reinfarction, and repeat revascularization.SUMMARY: The DANAMI 3 trial program will determine whether either of 2 approaches to reduce reperfusion injury and distal microvascular obstruction with postconditioning or deferred stent implantation will translate into improved clinical outcome and whether patients with multivessel disease undergoing primary percutaneous coronary intervention will benefit from a strategy of complete or partial revascularization.

KW - Adult

KW - Angioplasty, Balloon, Coronary

KW - Heart Failure/etiology

KW - Hospitalization

KW - Humans

KW - Ischemic Postconditioning

KW - Myocardial Infarction/complications

KW - Recurrence

KW - Research Design

KW - Stents

U2 - 10.1016/j.ahj.2015.02.004

DO - 10.1016/j.ahj.2015.02.004

M3 - SCORING: Journal article

C2 - 25965708

VL - 169

SP - 613

EP - 621

JO - AM HEART J

JF - AM HEART J

SN - 0002-8703

IS - 5

ER -