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The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression

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The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression. / Lazareth, Hélène; Henique, Carole; Lenoir, Olivia; Puelles, Victor G; Flamant, Martin; Bollée, Guillaume; Fligny, Cécile; Camus, Marine; Guyonnet, Lea; Millien, Corinne; Gaillard, François; Chipont, Anna; Robin, Blaise; Fabrega, Sylvie; Dhaun, Neeraj; Camerer, Eric; Kretz, Oliver; Grahammer, Florian; Braun, Fabian; Huber, Tobias B; Nochy, Dominique; Mandet, Chantal; Bruneval, Patrick; Mesnard, Laurent; Thervet, Eric; Karras, Alexandre; Le Naour, François; Rubinstein, Eric; Boucheix, Claude; Alexandrou, Antigoni; Moeller, Marcus J; Bouzigues, Cédric; Tharaux, Pierre-Louis.

in: NAT COMMUN, Jahrgang 10, Nr. 1, 24.07.2019, S. 3303.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lazareth, H, Henique, C, Lenoir, O, Puelles, VG, Flamant, M, Bollée, G, Fligny, C, Camus, M, Guyonnet, L, Millien, C, Gaillard, F, Chipont, A, Robin, B, Fabrega, S, Dhaun, N, Camerer, E, Kretz, O, Grahammer, F, Braun, F, Huber, TB, Nochy, D, Mandet, C, Bruneval, P, Mesnard, L, Thervet, E, Karras, A, Le Naour, F, Rubinstein, E, Boucheix, C, Alexandrou, A, Moeller, MJ, Bouzigues, C & Tharaux, P-L 2019, 'The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression', NAT COMMUN, Jg. 10, Nr. 1, S. 3303. https://doi.org/10.1038/s41467-019-11013-2

APA

Lazareth, H., Henique, C., Lenoir, O., Puelles, V. G., Flamant, M., Bollée, G., Fligny, C., Camus, M., Guyonnet, L., Millien, C., Gaillard, F., Chipont, A., Robin, B., Fabrega, S., Dhaun, N., Camerer, E., Kretz, O., Grahammer, F., Braun, F., ... Tharaux, P-L. (2019). The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression. NAT COMMUN, 10(1), 3303. https://doi.org/10.1038/s41467-019-11013-2

Vancouver

Lazareth H, Henique C, Lenoir O, Puelles VG, Flamant M, Bollée G et al. The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression. NAT COMMUN. 2019 Jul 24;10(1):3303. https://doi.org/10.1038/s41467-019-11013-2

Bibtex

@article{83258cd4a3f24537a6eab14598eb5ea1,
title = "The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression",
abstract = "The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show that expression of the tetraspanin CD9 increases markedly in PECs in mouse models of CGN and FSGS, and in kidneys from individuals diagnosed with these diseases. Cd9 gene targeting in PECs prevents glomerular damage in CGN and FSGS mouse models. Mechanistically, CD9 deficiency prevents the oriented migration of PECs into the glomerular tuft and their acquisition of CD44 and β1 integrin expression. These findings highlight a critical role for de novo expression of CD9 as a common pathogenic switch driving the PEC phenotype in CGN and FSGS, while offering a potential therapeutic avenue to treat these conditions.",
author = "H{\'e}l{\`e}ne Lazareth and Carole Henique and Olivia Lenoir and Puelles, {Victor G} and Martin Flamant and Guillaume Boll{\'e}e and C{\'e}cile Fligny and Marine Camus and Lea Guyonnet and Corinne Millien and Fran{\c c}ois Gaillard and Anna Chipont and Blaise Robin and Sylvie Fabrega and Neeraj Dhaun and Eric Camerer and Oliver Kretz and Florian Grahammer and Fabian Braun and Huber, {Tobias B} and Dominique Nochy and Chantal Mandet and Patrick Bruneval and Laurent Mesnard and Eric Thervet and Alexandre Karras and {Le Naour}, Fran{\c c}ois and Eric Rubinstein and Claude Boucheix and Antigoni Alexandrou and Moeller, {Marcus J} and C{\'e}dric Bouzigues and Pierre-Louis Tharaux",
year = "2019",
month = jul,
day = "24",
doi = "10.1038/s41467-019-11013-2",
language = "English",
volume = "10",
pages = "3303",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression

AU - Lazareth, Hélène

AU - Henique, Carole

AU - Lenoir, Olivia

AU - Puelles, Victor G

AU - Flamant, Martin

AU - Bollée, Guillaume

AU - Fligny, Cécile

AU - Camus, Marine

AU - Guyonnet, Lea

AU - Millien, Corinne

AU - Gaillard, François

AU - Chipont, Anna

AU - Robin, Blaise

AU - Fabrega, Sylvie

AU - Dhaun, Neeraj

AU - Camerer, Eric

AU - Kretz, Oliver

AU - Grahammer, Florian

AU - Braun, Fabian

AU - Huber, Tobias B

AU - Nochy, Dominique

AU - Mandet, Chantal

AU - Bruneval, Patrick

AU - Mesnard, Laurent

AU - Thervet, Eric

AU - Karras, Alexandre

AU - Le Naour, François

AU - Rubinstein, Eric

AU - Boucheix, Claude

AU - Alexandrou, Antigoni

AU - Moeller, Marcus J

AU - Bouzigues, Cédric

AU - Tharaux, Pierre-Louis

PY - 2019/7/24

Y1 - 2019/7/24

N2 - The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show that expression of the tetraspanin CD9 increases markedly in PECs in mouse models of CGN and FSGS, and in kidneys from individuals diagnosed with these diseases. Cd9 gene targeting in PECs prevents glomerular damage in CGN and FSGS mouse models. Mechanistically, CD9 deficiency prevents the oriented migration of PECs into the glomerular tuft and their acquisition of CD44 and β1 integrin expression. These findings highlight a critical role for de novo expression of CD9 as a common pathogenic switch driving the PEC phenotype in CGN and FSGS, while offering a potential therapeutic avenue to treat these conditions.

AB - The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show that expression of the tetraspanin CD9 increases markedly in PECs in mouse models of CGN and FSGS, and in kidneys from individuals diagnosed with these diseases. Cd9 gene targeting in PECs prevents glomerular damage in CGN and FSGS mouse models. Mechanistically, CD9 deficiency prevents the oriented migration of PECs into the glomerular tuft and their acquisition of CD44 and β1 integrin expression. These findings highlight a critical role for de novo expression of CD9 as a common pathogenic switch driving the PEC phenotype in CGN and FSGS, while offering a potential therapeutic avenue to treat these conditions.

U2 - 10.1038/s41467-019-11013-2

DO - 10.1038/s41467-019-11013-2

M3 - SCORING: Journal article

C2 - 31341160

VL - 10

SP - 3303

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -