The temporal and spectral characteristics of expectations and prediction errors in pain and thermoception

TY - JOUR

T1 - The temporal and spectral characteristics of expectations and prediction errors in pain and thermoception

AU - Strube, Andreas

AU - Rose, Michael

AU - Fazeli, Sepideh

AU - Büchel, Christian

N1 - Sepideh Fazeli war Mitarbeiterin des Inst f syst Neurowiss zum Zeitpunkt der Studie

PY - 2021/2/17

Y1 - 2021/2/17

N2 - In the context of a generative model, such as predictive coding, pain and heat perception can be construed as the integration of expectation and input with their difference denoted as a prediction error. In a previous neuroimaging study (Geuter et al., 2017) we observed an important role of the insula in such a model but could not establish its temporal aspects. Here, we employed electroencephalography to investigate neural representations of predictions and prediction errors in heat and pain processing. Our data show that alpha-to-beta activity was associated with stimulus intensity expectation, followed by a negative modulation of gamma band activity by absolute prediction errors. This is in contrast to prediction errors in visual and auditory perception, which are associated with increased gamma band activity, but is in agreement with observations in working memory and word matching, which show gamma band activity for correct, rather than violated, predictions.

AB - In the context of a generative model, such as predictive coding, pain and heat perception can be construed as the integration of expectation and input with their difference denoted as a prediction error. In a previous neuroimaging study (Geuter et al., 2017) we observed an important role of the insula in such a model but could not establish its temporal aspects. Here, we employed electroencephalography to investigate neural representations of predictions and prediction errors in heat and pain processing. Our data show that alpha-to-beta activity was associated with stimulus intensity expectation, followed by a negative modulation of gamma band activity by absolute prediction errors. This is in contrast to prediction errors in visual and auditory perception, which are associated with increased gamma band activity, but is in agreement with observations in working memory and word matching, which show gamma band activity for correct, rather than violated, predictions.

U2 - 10.7554/eLife.62809

DO - 10.7554/eLife.62809

M3 - SCORING: Journal article

C2 - 33594976

VL - 10

JO - ELIFE

JF - ELIFE

SN - 2050-084X

ER -