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The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups: Formulating Radiotherapy Decision-Making Based on Age

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The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups: Formulating Radiotherapy Decision-Making Based on Age. / Li, Yuqiang; Liu, Heli; Zhou, Yuan; Zhou, Zhongyi; Liu, Wenxue; Zhao, Lilan; Güngör, Cenap; Wang, Dan; Pei, Qian; Pei, Haiping; Tan, Fengbo.

in: FRONT ONCOL, Jahrgang 11, 2021, S. 695640.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Li, Y, Liu, H, Zhou, Y, Zhou, Z, Liu, W, Zhao, L, Güngör, C, Wang, D, Pei, Q, Pei, H & Tan, F 2021, 'The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups: Formulating Radiotherapy Decision-Making Based on Age', FRONT ONCOL, Jg. 11, S. 695640. https://doi.org/10.3389/fonc.2021.695640

APA

Li, Y., Liu, H., Zhou, Y., Zhou, Z., Liu, W., Zhao, L., Güngör, C., Wang, D., Pei, Q., Pei, H., & Tan, F. (2021). The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups: Formulating Radiotherapy Decision-Making Based on Age. FRONT ONCOL, 11, 695640. https://doi.org/10.3389/fonc.2021.695640

Vancouver

Li Y, Liu H, Zhou Y, Zhou Z, Liu W, Zhao L et al. The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups: Formulating Radiotherapy Decision-Making Based on Age. FRONT ONCOL. 2021;11:695640. https://doi.org/10.3389/fonc.2021.695640

Bibtex

@article{32156edce76a43819cd6c06f2b73575d,
title = "The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups: Formulating Radiotherapy Decision-Making Based on Age",
abstract = "Introduction: Total mesorectal excision (TME), chemotherapy (CT), and radiotherapy (RT) are usually integrated into the comprehensive treatment of stage II/III rectal cancer (RC). Neoadjuvant radiotherapy (nRT) has become the standard treatment for stage II/III RC patients to help reduce the size of a tumor or kill cancer cells that have spread. Adjuvant RT is delivered after the resection to destroy remaining cancer cells and used mainly in stage II/III RC patients who have not received preoperative radiotherapy, such as those who suffered from a bowel obstruction before surgery. It is controversial whether radiotherapy can improve the survival of stage II/III RC patients. An increasing number of studies have reported that rectal cancer exhibited mismatched biology, epidemiology, and therapeutic response to current treatment strategy in different age groups. It is necessary to investigate whether radiotherapy exhibits disparate effects in different age groups of patients with stage II/III RC.Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) Program was extracted to identify stage II/III RC diagnosed in the periods of 2004-2016. The statistical methods included Pearson's chi-square test, log-rank test, Cox regression model, and propensity score matching.Results: Neoadjuvant radiotherapy (nRT) cannot improve the prognosis, and postoperative RT may even reduce the survival time for early onset stage II/III RC. Postoperative RT was not able to improve the overall survival (OS), while nRT may provide limited survival improvement for middle-aged stage II/III RC patients. In addition, radiotherapy can significantly improve the prognosis for elderly stage II/III RC.Conclusions: This study indicated the inconsistent survival effect of radiotherapy on stage II/III rectal cancer patients in different age groups. Hence, we formulated a novel flow chart of radiotherapy decision-making based on age in stage II/III RC patients.",
author = "Yuqiang Li and Heli Liu and Yuan Zhou and Zhongyi Zhou and Wenxue Liu and Lilan Zhao and Cenap G{\"u}ng{\"o}r and Dan Wang and Qian Pei and Haiping Pei and Fengbo Tan",
note = "Copyright {\textcopyright} 2021 Li, Liu, Zhou, Zhou, Liu, Zhao, G{\"u}ng{\"o}r, Wang, Pei, Pei and Tan.",
year = "2021",
doi = "10.3389/fonc.2021.695640",
language = "English",
volume = "11",
pages = "695640",
journal = "FRONT ONCOL",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups: Formulating Radiotherapy Decision-Making Based on Age

AU - Li, Yuqiang

AU - Liu, Heli

AU - Zhou, Yuan

AU - Zhou, Zhongyi

AU - Liu, Wenxue

AU - Zhao, Lilan

AU - Güngör, Cenap

AU - Wang, Dan

AU - Pei, Qian

AU - Pei, Haiping

AU - Tan, Fengbo

N1 - Copyright © 2021 Li, Liu, Zhou, Zhou, Liu, Zhao, Güngör, Wang, Pei, Pei and Tan.

PY - 2021

Y1 - 2021

N2 - Introduction: Total mesorectal excision (TME), chemotherapy (CT), and radiotherapy (RT) are usually integrated into the comprehensive treatment of stage II/III rectal cancer (RC). Neoadjuvant radiotherapy (nRT) has become the standard treatment for stage II/III RC patients to help reduce the size of a tumor or kill cancer cells that have spread. Adjuvant RT is delivered after the resection to destroy remaining cancer cells and used mainly in stage II/III RC patients who have not received preoperative radiotherapy, such as those who suffered from a bowel obstruction before surgery. It is controversial whether radiotherapy can improve the survival of stage II/III RC patients. An increasing number of studies have reported that rectal cancer exhibited mismatched biology, epidemiology, and therapeutic response to current treatment strategy in different age groups. It is necessary to investigate whether radiotherapy exhibits disparate effects in different age groups of patients with stage II/III RC.Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) Program was extracted to identify stage II/III RC diagnosed in the periods of 2004-2016. The statistical methods included Pearson's chi-square test, log-rank test, Cox regression model, and propensity score matching.Results: Neoadjuvant radiotherapy (nRT) cannot improve the prognosis, and postoperative RT may even reduce the survival time for early onset stage II/III RC. Postoperative RT was not able to improve the overall survival (OS), while nRT may provide limited survival improvement for middle-aged stage II/III RC patients. In addition, radiotherapy can significantly improve the prognosis for elderly stage II/III RC.Conclusions: This study indicated the inconsistent survival effect of radiotherapy on stage II/III rectal cancer patients in different age groups. Hence, we formulated a novel flow chart of radiotherapy decision-making based on age in stage II/III RC patients.

AB - Introduction: Total mesorectal excision (TME), chemotherapy (CT), and radiotherapy (RT) are usually integrated into the comprehensive treatment of stage II/III rectal cancer (RC). Neoadjuvant radiotherapy (nRT) has become the standard treatment for stage II/III RC patients to help reduce the size of a tumor or kill cancer cells that have spread. Adjuvant RT is delivered after the resection to destroy remaining cancer cells and used mainly in stage II/III RC patients who have not received preoperative radiotherapy, such as those who suffered from a bowel obstruction before surgery. It is controversial whether radiotherapy can improve the survival of stage II/III RC patients. An increasing number of studies have reported that rectal cancer exhibited mismatched biology, epidemiology, and therapeutic response to current treatment strategy in different age groups. It is necessary to investigate whether radiotherapy exhibits disparate effects in different age groups of patients with stage II/III RC.Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) Program was extracted to identify stage II/III RC diagnosed in the periods of 2004-2016. The statistical methods included Pearson's chi-square test, log-rank test, Cox regression model, and propensity score matching.Results: Neoadjuvant radiotherapy (nRT) cannot improve the prognosis, and postoperative RT may even reduce the survival time for early onset stage II/III RC. Postoperative RT was not able to improve the overall survival (OS), while nRT may provide limited survival improvement for middle-aged stage II/III RC patients. In addition, radiotherapy can significantly improve the prognosis for elderly stage II/III RC.Conclusions: This study indicated the inconsistent survival effect of radiotherapy on stage II/III rectal cancer patients in different age groups. Hence, we formulated a novel flow chart of radiotherapy decision-making based on age in stage II/III RC patients.

U2 - 10.3389/fonc.2021.695640

DO - 10.3389/fonc.2021.695640

M3 - SCORING: Journal article

C2 - 34395261

VL - 11

SP - 695640

JO - FRONT ONCOL

JF - FRONT ONCOL

SN - 2234-943X

ER -