PortalPublikationenThe significance of PTEN and AKT aberrations in pediatric T-...

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.

  • Linda Zuurbier
  • Emanuel F Petricoin
  • Maartje J Vuerhard
  • Valerie Calvert
  • Clarissa Kooi
  • Jessica G C A M Buijs-Gladdines
  • Willem K Smits
  • Edwin Sonneveld
  • Anjo J P Veerman
  • Willem A Kamps
  • Martin Horstmann
  • Rob Pieters
  • Jules P P Meijerink

Beteiligte Einrichtungen

Abstract

PI3K/AKT pathway mutations are found in T-cell acute lymphoblastic leukemia, but their overall impact and associations with other genetic aberrations is unknown. PTEN mutations have been proposed as secondary mutations that follow NOTCH1-activating mutations and cause cellular resistance to ?-secretase inhibitors.

Bibliografische Daten

OriginalspracheEnglisch
Aufsatznummer9
ISSN0390-6078
DOIs
StatusVeröffentlicht - 2012
pubmed 22491738