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The serum and glucocorticoid-regulated kinase 1 in hypoxic renal injury.

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The serum and glucocorticoid-regulated kinase 1 in hypoxic renal injury. / Rusai, Krisztina; Wagner, Bettina; Roos, Marcel; Schmaderer, Christoph; Strobl, Matthias; Boini, Krishna M; Grenz, Almut; Kuhl, Dietmar; Heemann, Uwe; Lang, Florian; Lutz, Jens.

in: CELL PHYSIOL BIOCHEM, Jahrgang 24, Nr. 5-6, 5-6, 2009, S. 577-584.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rusai, K, Wagner, B, Roos, M, Schmaderer, C, Strobl, M, Boini, KM, Grenz, A, Kuhl, D, Heemann, U, Lang, F & Lutz, J 2009, 'The serum and glucocorticoid-regulated kinase 1 in hypoxic renal injury.', CELL PHYSIOL BIOCHEM, Jg. 24, Nr. 5-6, 5-6, S. 577-584. https://doi.org/10.1159/000257527

APA

Rusai, K., Wagner, B., Roos, M., Schmaderer, C., Strobl, M., Boini, K. M., Grenz, A., Kuhl, D., Heemann, U., Lang, F., & Lutz, J. (2009). The serum and glucocorticoid-regulated kinase 1 in hypoxic renal injury. CELL PHYSIOL BIOCHEM, 24(5-6), 577-584. [5-6]. https://doi.org/10.1159/000257527

Vancouver

Rusai K, Wagner B, Roos M, Schmaderer C, Strobl M, Boini KM et al. The serum and glucocorticoid-regulated kinase 1 in hypoxic renal injury. CELL PHYSIOL BIOCHEM. 2009;24(5-6):577-584. 5-6. https://doi.org/10.1159/000257527

Bibtex

@article{b384373582ba441caa5cabdf8981e24b,
title = "The serum and glucocorticoid-regulated kinase 1 in hypoxic renal injury.",
abstract = "The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine threonine protein kinase activated through the phosphatidylinositol 3-kinase (PI3-kinase) pathway and counteracting apoptosis. Protein expression and activation of SGK1 are increased in various models of cell stress. The present study explored the role of SGK1 in renal hypoxia/ischemia induced apoptosis. HEK 293 cells were exposed in vitro to hypoxia/reoxygenation (H/R), which increased SGK1 transcript levels, SGK1 protein abundance and SGK1 phosphorylation. H/R injury further enhanced the percentage of apoptotic cells, an effect significantly blunted by prior SGK1 overexpression. In vivo renal ischemia/reperfusion (I/R) injury increased SGK1 transcript levels and SGK1 protein abundance. I/R enhanced apoptosis, an effect significantly more pronounced in gene targeted mice lacking SGK1. In conclusion, SGK1 is up-regulated and counteracts apoptosis following H/R in vitro and ischemia In vivo.",
author = "Krisztina Rusai and Bettina Wagner and Marcel Roos and Christoph Schmaderer and Matthias Strobl and Boini, {Krishna M} and Almut Grenz and Dietmar Kuhl and Uwe Heemann and Florian Lang and Jens Lutz",
year = "2009",
doi = "10.1159/000257527",
language = "Deutsch",
volume = "24",
pages = "577--584",
journal = "CELL PHYSIOL BIOCHEM",
issn = "1015-8987",
publisher = "S. Karger AG",
number = "5-6",

}

RIS

TY - JOUR

T1 - The serum and glucocorticoid-regulated kinase 1 in hypoxic renal injury.

AU - Rusai, Krisztina

AU - Wagner, Bettina

AU - Roos, Marcel

AU - Schmaderer, Christoph

AU - Strobl, Matthias

AU - Boini, Krishna M

AU - Grenz, Almut

AU - Kuhl, Dietmar

AU - Heemann, Uwe

AU - Lang, Florian

AU - Lutz, Jens

PY - 2009

Y1 - 2009

N2 - The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine threonine protein kinase activated through the phosphatidylinositol 3-kinase (PI3-kinase) pathway and counteracting apoptosis. Protein expression and activation of SGK1 are increased in various models of cell stress. The present study explored the role of SGK1 in renal hypoxia/ischemia induced apoptosis. HEK 293 cells were exposed in vitro to hypoxia/reoxygenation (H/R), which increased SGK1 transcript levels, SGK1 protein abundance and SGK1 phosphorylation. H/R injury further enhanced the percentage of apoptotic cells, an effect significantly blunted by prior SGK1 overexpression. In vivo renal ischemia/reperfusion (I/R) injury increased SGK1 transcript levels and SGK1 protein abundance. I/R enhanced apoptosis, an effect significantly more pronounced in gene targeted mice lacking SGK1. In conclusion, SGK1 is up-regulated and counteracts apoptosis following H/R in vitro and ischemia In vivo.

AB - The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine threonine protein kinase activated through the phosphatidylinositol 3-kinase (PI3-kinase) pathway and counteracting apoptosis. Protein expression and activation of SGK1 are increased in various models of cell stress. The present study explored the role of SGK1 in renal hypoxia/ischemia induced apoptosis. HEK 293 cells were exposed in vitro to hypoxia/reoxygenation (H/R), which increased SGK1 transcript levels, SGK1 protein abundance and SGK1 phosphorylation. H/R injury further enhanced the percentage of apoptotic cells, an effect significantly blunted by prior SGK1 overexpression. In vivo renal ischemia/reperfusion (I/R) injury increased SGK1 transcript levels and SGK1 protein abundance. I/R enhanced apoptosis, an effect significantly more pronounced in gene targeted mice lacking SGK1. In conclusion, SGK1 is up-regulated and counteracts apoptosis following H/R in vitro and ischemia In vivo.

U2 - 10.1159/000257527

DO - 10.1159/000257527

M3 - SCORING: Zeitschriftenaufsatz

VL - 24

SP - 577

EP - 584

JO - CELL PHYSIOL BIOCHEM

JF - CELL PHYSIOL BIOCHEM

SN - 1015-8987

IS - 5-6

M1 - 5-6

ER -