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The Role of TAM Receptors in Bone

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The Role of TAM Receptors in Bone. / Engelmann, Janik; Ragipoglu, Deniz; Ben Batalla, Isabel; Loges, Sonja.

in: INT J MOL SCI, Jahrgang 25, Nr. 1, 233, 23.12.2023.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Engelmann, J, Ragipoglu, D, Ben Batalla, I & Loges, S 2023, 'The Role of TAM Receptors in Bone', INT J MOL SCI, Jg. 25, Nr. 1, 233. https://doi.org/10.3390/ijms25010233

APA

Engelmann, J., Ragipoglu, D., Ben Batalla, I., & Loges, S. (2023). The Role of TAM Receptors in Bone. INT J MOL SCI, 25(1), [233]. https://doi.org/10.3390/ijms25010233

Vancouver

Engelmann J, Ragipoglu D, Ben Batalla I, Loges S. The Role of TAM Receptors in Bone. INT J MOL SCI. 2023 Dez 23;25(1). 233. https://doi.org/10.3390/ijms25010233

Bibtex

@article{47bce22b212a498abc24c274872297d2,
title = "The Role of TAM Receptors in Bone",
abstract = "The TAM (TYRO3, MERTK, and AXL) family of receptor tyrosine kinases are pleiotropic regulators of adult tissue homeostasis maintaining organ integrity and self-renewal. Disruption of their homeostatic balance fosters pathological conditions like autoinflammatory or degenerative diseases including rheumatoid arthritis, lupus erythematodes, or liver fibrosis. Moreover, TAM receptors exhibit prominent cell-transforming properties, promoting tumor progression, metastasis, and therapy resistance in various cancer entities. Emerging evidence shows that TAM receptors are involved in bone homeostasis by regulating osteoblastic bone formation and osteoclastic bone resorption. Therefore, TAM receptors emerge as new key players of the regulatory cytokine network of osteoblasts and osteoclasts and represent accessible targets for pharmacologic therapy for a broad set of different bone diseases, including primary and metastatic bone tumors, rheumatoid arthritis, or osteoporosis.",
author = "Janik Engelmann and Deniz Ragipoglu and {Ben Batalla}, Isabel and Sonja Loges",
year = "2023",
month = dec,
day = "23",
doi = "10.3390/ijms25010233",
language = "English",
volume = "25",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

RIS

TY - JOUR

T1 - The Role of TAM Receptors in Bone

AU - Engelmann, Janik

AU - Ragipoglu, Deniz

AU - Ben Batalla, Isabel

AU - Loges, Sonja

PY - 2023/12/23

Y1 - 2023/12/23

N2 - The TAM (TYRO3, MERTK, and AXL) family of receptor tyrosine kinases are pleiotropic regulators of adult tissue homeostasis maintaining organ integrity and self-renewal. Disruption of their homeostatic balance fosters pathological conditions like autoinflammatory or degenerative diseases including rheumatoid arthritis, lupus erythematodes, or liver fibrosis. Moreover, TAM receptors exhibit prominent cell-transforming properties, promoting tumor progression, metastasis, and therapy resistance in various cancer entities. Emerging evidence shows that TAM receptors are involved in bone homeostasis by regulating osteoblastic bone formation and osteoclastic bone resorption. Therefore, TAM receptors emerge as new key players of the regulatory cytokine network of osteoblasts and osteoclasts and represent accessible targets for pharmacologic therapy for a broad set of different bone diseases, including primary and metastatic bone tumors, rheumatoid arthritis, or osteoporosis.

AB - The TAM (TYRO3, MERTK, and AXL) family of receptor tyrosine kinases are pleiotropic regulators of adult tissue homeostasis maintaining organ integrity and self-renewal. Disruption of their homeostatic balance fosters pathological conditions like autoinflammatory or degenerative diseases including rheumatoid arthritis, lupus erythematodes, or liver fibrosis. Moreover, TAM receptors exhibit prominent cell-transforming properties, promoting tumor progression, metastasis, and therapy resistance in various cancer entities. Emerging evidence shows that TAM receptors are involved in bone homeostasis by regulating osteoblastic bone formation and osteoclastic bone resorption. Therefore, TAM receptors emerge as new key players of the regulatory cytokine network of osteoblasts and osteoclasts and represent accessible targets for pharmacologic therapy for a broad set of different bone diseases, including primary and metastatic bone tumors, rheumatoid arthritis, or osteoporosis.

U2 - 10.3390/ijms25010233

DO - 10.3390/ijms25010233

M3 - SCORING: Review article

VL - 25

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 1

M1 - 233

ER -