The role of natural killer cells in liver inflammation

A J Highton; I S Schuster; M A Degli-Esposti; M Altfeld

doi:10.1007/s00281-021-00877-6

The role of natural killer cells in liver inflammation

Standard

The role of natural killer cells in liver inflammation. / Highton, A J; Schuster, I S; Degli-Esposti, M A; Altfeld, M.

in: SEMIN IMMUNOPATHOL, Jahrgang 43, Nr. 4, 08.2021, S. 519-533.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Highton, AJ, Schuster, IS, Degli-Esposti, MA & Altfeld, M 2021, 'The role of natural killer cells in liver inflammation', SEMIN IMMUNOPATHOL, Jg. 43, Nr. 4, S. 519-533. https://doi.org/10.1007/s00281-021-00877-6

APA

Highton, A. J., Schuster, I. S., Degli-Esposti, M. A., & Altfeld, M. (2021). The role of natural killer cells in liver inflammation. SEMIN IMMUNOPATHOL, 43(4), 519-533. https://doi.org/10.1007/s00281-021-00877-6

Vancouver

Highton AJ, Schuster IS, Degli-Esposti MA, Altfeld M. The role of natural killer cells in liver inflammation. SEMIN IMMUNOPATHOL. 2021 Aug;43(4):519-533. https://doi.org/10.1007/s00281-021-00877-6

Bibtex

@article{ec9abac7805448fba85727d39beaf588,

title = "The role of natural killer cells in liver inflammation",

abstract = "The liver is an important immunological site that can promote immune tolerance or activation. Natural killer (NK) cells are a major immune subset within the liver, and therefore understanding their role in liver homeostasis and inflammation is crucial. Due to their cytotoxic function, NK cells are important in the immune response against hepatotropic viral infections but are also involved in the inflammatory processes of autoimmune liver diseases and fatty liver disease. Whether NK cells primarily promote pro-inflammatory or tolerogenic responses is not known for many liver diseases. Understanding the involvement of NK cells in liver inflammation will be crucial in effective treatment and future immunotherapeutic targeting of NK cells in these disease settings. Here, we explore the role that NK cells play in inflammation of the liver in the context of viral infection, autoimmunity and fatty liver disease.",

keywords = "Autoimmune Diseases, Humans, Inflammation, Killer Cells, Natural, Liver, Liver Diseases",

author = "Highton, {A J} and Schuster, {I S} and Degli-Esposti, {M A} and M Altfeld",

note = "{\textcopyright} 2021. The Author(s).",

year = "2021",

month = aug,

doi = "10.1007/s00281-021-00877-6",

language = "English",

volume = "43",

pages = "519--533",

journal = "SEMIN IMMUNOPATHOL",

issn = "1863-2297",

publisher = "Springer",

number = "4",

}

RIS

TY - JOUR

T1 - The role of natural killer cells in liver inflammation

AU - Highton, A J

AU - Schuster, I S

AU - Degli-Esposti, M A

AU - Altfeld, M

PY - 2021/8

Y1 - 2021/8

N2 - The liver is an important immunological site that can promote immune tolerance or activation. Natural killer (NK) cells are a major immune subset within the liver, and therefore understanding their role in liver homeostasis and inflammation is crucial. Due to their cytotoxic function, NK cells are important in the immune response against hepatotropic viral infections but are also involved in the inflammatory processes of autoimmune liver diseases and fatty liver disease. Whether NK cells primarily promote pro-inflammatory or tolerogenic responses is not known for many liver diseases. Understanding the involvement of NK cells in liver inflammation will be crucial in effective treatment and future immunotherapeutic targeting of NK cells in these disease settings. Here, we explore the role that NK cells play in inflammation of the liver in the context of viral infection, autoimmunity and fatty liver disease.

AB - The liver is an important immunological site that can promote immune tolerance or activation. Natural killer (NK) cells are a major immune subset within the liver, and therefore understanding their role in liver homeostasis and inflammation is crucial. Due to their cytotoxic function, NK cells are important in the immune response against hepatotropic viral infections but are also involved in the inflammatory processes of autoimmune liver diseases and fatty liver disease. Whether NK cells primarily promote pro-inflammatory or tolerogenic responses is not known for many liver diseases. Understanding the involvement of NK cells in liver inflammation will be crucial in effective treatment and future immunotherapeutic targeting of NK cells in these disease settings. Here, we explore the role that NK cells play in inflammation of the liver in the context of viral infection, autoimmunity and fatty liver disease.

KW - Autoimmune Diseases

KW - Humans

KW - Inflammation

KW - Killer Cells, Natural

KW - Liver

KW - Liver Diseases

U2 - 10.1007/s00281-021-00877-6

DO - 10.1007/s00281-021-00877-6

M3 - SCORING: Review article

C2 - 34230995

VL - 43

SP - 519

EP - 533

JO - SEMIN IMMUNOPATHOL

JF - SEMIN IMMUNOPATHOL

SN - 1863-2297

IS - 4

ER -