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The Risk of Contralateral Non-sentinel Metastasis in Patients with Primary Vulvar Cancer and Unilaterally Positive Sentinel Node

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The Risk of Contralateral Non-sentinel Metastasis in Patients with Primary Vulvar Cancer and Unilaterally Positive Sentinel Node. / Woelber, Linn; Eulenburg, Christine; Grimm, Donata; Trillsch, Fabian; Bohlmann, Inga; Burandt, Eike; Dieckmann, Jan; Klutmann, Susanne; Schmalfeldt, Barbara; Mahner, Sven; Prieske, Katharina.

in: ANN SURG ONCOL, Jahrgang 23, Nr. 8, 08.2016, S. 2508-14.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Woelber, L, Eulenburg, C, Grimm, D, Trillsch, F, Bohlmann, I, Burandt, E, Dieckmann, J, Klutmann, S, Schmalfeldt, B, Mahner, S & Prieske, K 2016, 'The Risk of Contralateral Non-sentinel Metastasis in Patients with Primary Vulvar Cancer and Unilaterally Positive Sentinel Node', ANN SURG ONCOL, Jg. 23, Nr. 8, S. 2508-14. https://doi.org/10.1245/s10434-016-5114-6

APA

Woelber, L., Eulenburg, C., Grimm, D., Trillsch, F., Bohlmann, I., Burandt, E., Dieckmann, J., Klutmann, S., Schmalfeldt, B., Mahner, S., & Prieske, K. (2016). The Risk of Contralateral Non-sentinel Metastasis in Patients with Primary Vulvar Cancer and Unilaterally Positive Sentinel Node. ANN SURG ONCOL, 23(8), 2508-14. https://doi.org/10.1245/s10434-016-5114-6

Vancouver

Woelber L, Eulenburg C, Grimm D, Trillsch F, Bohlmann I, Burandt E et al. The Risk of Contralateral Non-sentinel Metastasis in Patients with Primary Vulvar Cancer and Unilaterally Positive Sentinel Node. ANN SURG ONCOL. 2016 Aug;23(8):2508-14. https://doi.org/10.1245/s10434-016-5114-6

Bibtex

@article{891a8c99ce3547e0b7541410fdb6410f,
title = "The Risk of Contralateral Non-sentinel Metastasis in Patients with Primary Vulvar Cancer and Unilaterally Positive Sentinel Node",
abstract = "BACKGROUND: In patients with primary vulvar cancer and bilateral sentinel lymph node (SLN) biopsy, bilateral complete inguino-femoral lymphadenectomy (LAE) is recommended, even in cases with only unilaterally positive SLN by most guidelines. The risk of contralateral non-SLN metastasis is unclear.METHODS: All patients with primary vulvar cancer receiving an SLN dissection with radioactive tracer ± blue dye at the University Medical Center Hamburg-Eppendorf between 2001 and 2013 were retrospectively evaluated. Median follow-up was 33 months.RESULTS: A total of 140 patients were included; 124 with bilateral and 16 with unilateral SLN dissection. A median number of two SLNs (range 1-7) per groin were dissected. Overall, 53 (53/140, 37.9 %) patients received a complete inguino-femoral LAE, 41 of whom (77.4 %) had previously presented with a positive SLN (33 unilaterally, 8 bilaterally). Of the 33 patients with unilaterally positive SLN, 28 (84.9 %) underwent complete bilateral inguino-femoral LAE despite a contralateral negative SLN. Of these patients, none presented a contralateral non-SLN metastasis (0/28, 0 %) in full dissection; however, one developed groin recurrence in the initially SLN-negative, fully dissected groin after 19 months (1/28, 3.6 %).CONCLUSION: In case of bilateral SLN biopsy for clinically node-negative disease and only unilaterally positive SLN, the risk for contralateral non-SLN metastases appears to be low. These data support the omission of contralateral LAE to reduce surgical morbidity.",
author = "Linn Woelber and Christine Eulenburg and Donata Grimm and Fabian Trillsch and Inga Bohlmann and Eike Burandt and Jan Dieckmann and Susanne Klutmann and Barbara Schmalfeldt and Sven Mahner and Katharina Prieske",
year = "2016",
month = aug,
doi = "10.1245/s10434-016-5114-6",
language = "English",
volume = "23",
pages = "2508--14",
journal = "ANN SURG ONCOL",
issn = "1068-9265",
publisher = "Springer New York",
number = "8",

}

RIS

TY - JOUR

T1 - The Risk of Contralateral Non-sentinel Metastasis in Patients with Primary Vulvar Cancer and Unilaterally Positive Sentinel Node

AU - Woelber, Linn

AU - Eulenburg, Christine

AU - Grimm, Donata

AU - Trillsch, Fabian

AU - Bohlmann, Inga

AU - Burandt, Eike

AU - Dieckmann, Jan

AU - Klutmann, Susanne

AU - Schmalfeldt, Barbara

AU - Mahner, Sven

AU - Prieske, Katharina

PY - 2016/8

Y1 - 2016/8

N2 - BACKGROUND: In patients with primary vulvar cancer and bilateral sentinel lymph node (SLN) biopsy, bilateral complete inguino-femoral lymphadenectomy (LAE) is recommended, even in cases with only unilaterally positive SLN by most guidelines. The risk of contralateral non-SLN metastasis is unclear.METHODS: All patients with primary vulvar cancer receiving an SLN dissection with radioactive tracer ± blue dye at the University Medical Center Hamburg-Eppendorf between 2001 and 2013 were retrospectively evaluated. Median follow-up was 33 months.RESULTS: A total of 140 patients were included; 124 with bilateral and 16 with unilateral SLN dissection. A median number of two SLNs (range 1-7) per groin were dissected. Overall, 53 (53/140, 37.9 %) patients received a complete inguino-femoral LAE, 41 of whom (77.4 %) had previously presented with a positive SLN (33 unilaterally, 8 bilaterally). Of the 33 patients with unilaterally positive SLN, 28 (84.9 %) underwent complete bilateral inguino-femoral LAE despite a contralateral negative SLN. Of these patients, none presented a contralateral non-SLN metastasis (0/28, 0 %) in full dissection; however, one developed groin recurrence in the initially SLN-negative, fully dissected groin after 19 months (1/28, 3.6 %).CONCLUSION: In case of bilateral SLN biopsy for clinically node-negative disease and only unilaterally positive SLN, the risk for contralateral non-SLN metastases appears to be low. These data support the omission of contralateral LAE to reduce surgical morbidity.

AB - BACKGROUND: In patients with primary vulvar cancer and bilateral sentinel lymph node (SLN) biopsy, bilateral complete inguino-femoral lymphadenectomy (LAE) is recommended, even in cases with only unilaterally positive SLN by most guidelines. The risk of contralateral non-SLN metastasis is unclear.METHODS: All patients with primary vulvar cancer receiving an SLN dissection with radioactive tracer ± blue dye at the University Medical Center Hamburg-Eppendorf between 2001 and 2013 were retrospectively evaluated. Median follow-up was 33 months.RESULTS: A total of 140 patients were included; 124 with bilateral and 16 with unilateral SLN dissection. A median number of two SLNs (range 1-7) per groin were dissected. Overall, 53 (53/140, 37.9 %) patients received a complete inguino-femoral LAE, 41 of whom (77.4 %) had previously presented with a positive SLN (33 unilaterally, 8 bilaterally). Of the 33 patients with unilaterally positive SLN, 28 (84.9 %) underwent complete bilateral inguino-femoral LAE despite a contralateral negative SLN. Of these patients, none presented a contralateral non-SLN metastasis (0/28, 0 %) in full dissection; however, one developed groin recurrence in the initially SLN-negative, fully dissected groin after 19 months (1/28, 3.6 %).CONCLUSION: In case of bilateral SLN biopsy for clinically node-negative disease and only unilaterally positive SLN, the risk for contralateral non-SLN metastases appears to be low. These data support the omission of contralateral LAE to reduce surgical morbidity.

U2 - 10.1245/s10434-016-5114-6

DO - 10.1245/s10434-016-5114-6

M3 - SCORING: Journal article

C2 - 26856721

VL - 23

SP - 2508

EP - 2514

JO - ANN SURG ONCOL

JF - ANN SURG ONCOL

SN - 1068-9265

IS - 8

ER -