The right posterior inferior frontal gyrus contributes to phonological word decisions in the healthy brain: evidence from dual-site TMS.
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The right posterior inferior frontal gyrus contributes to phonological word decisions in the healthy brain: evidence from dual-site TMS. / Hartwigsen, Gesa; Price, Cathy J; Baumgärtner, Annette; Geiss, Gesine; Koehnke, Maria; Ulmer, Stephan; Siebner, Hartwig R.
in: NEUROPSYCHOLOGIA, Jahrgang 48, Nr. 10, 10, 2010, S. 3155-3163.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - The right posterior inferior frontal gyrus contributes to phonological word decisions in the healthy brain: evidence from dual-site TMS.
AU - Hartwigsen, Gesa
AU - Price, Cathy J
AU - Baumgärtner, Annette
AU - Geiss, Gesine
AU - Koehnke, Maria
AU - Ulmer, Stephan
AU - Siebner, Hartwig R
PY - 2010
Y1 - 2010
N2 - There is consensus that the left hemisphere plays a dominant role in language processing, but functional imaging studies have shown that the right as well as the left posterior inferior frontal gyri (pIFG) are activated when healthy right-handed individuals make phonological word decisions. Here we used online transcranial magnetic stimulation (TMS) to examine the functional relevance of the right pIFG for auditory and visual phonological decisions. Healthy right-handed individuals made phonological or semantic word judgements on the same set of auditorily and visually presented words while they received stereotactically guided TMS over the left, right or bilateral pIFG (n=14) or the anterior left, right or bilateral IFG (n=14). TMS started 100ms after word onset and consisted of four stimuli given at a rate of 10Hz and intensity of 90% of active motor threshold. Compared to TMS of aIFG, TMS of pIFG impaired reaction times and accuracy of phonological but not semantic decisions for visually and auditorily presented words. TMS over left, right or bilateral pIFG disrupted phonological processing to a similar degree. In a follow-up experiment, the intensity threshold for delaying phonological judgements was identical for unilateral TMS of left and right pIFG. These findings indicate that an intact function of right pIFG is necessary for accurate and efficient phonological decisions in the healthy brain with no evidence that the left and right pIFG can compensate for one another during online TMS. Our findings motivate detailed studies of phonological processing in patients with acute and chronic damage of the right pIFG.
AB - There is consensus that the left hemisphere plays a dominant role in language processing, but functional imaging studies have shown that the right as well as the left posterior inferior frontal gyri (pIFG) are activated when healthy right-handed individuals make phonological word decisions. Here we used online transcranial magnetic stimulation (TMS) to examine the functional relevance of the right pIFG for auditory and visual phonological decisions. Healthy right-handed individuals made phonological or semantic word judgements on the same set of auditorily and visually presented words while they received stereotactically guided TMS over the left, right or bilateral pIFG (n=14) or the anterior left, right or bilateral IFG (n=14). TMS started 100ms after word onset and consisted of four stimuli given at a rate of 10Hz and intensity of 90% of active motor threshold. Compared to TMS of aIFG, TMS of pIFG impaired reaction times and accuracy of phonological but not semantic decisions for visually and auditorily presented words. TMS over left, right or bilateral pIFG disrupted phonological processing to a similar degree. In a follow-up experiment, the intensity threshold for delaying phonological judgements was identical for unilateral TMS of left and right pIFG. These findings indicate that an intact function of right pIFG is necessary for accurate and efficient phonological decisions in the healthy brain with no evidence that the left and right pIFG can compensate for one another during online TMS. Our findings motivate detailed studies of phonological processing in patients with acute and chronic damage of the right pIFG.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Neuropsychological Tests
KW - Follow-Up Studies
KW - Oxygen blood
KW - Magnetic Resonance Imaging methods
KW - Analysis of Variance
KW - Brain Mapping
KW - Image Processing, Computer-Assisted methods
KW - Functional Laterality physiology
KW - Photic Stimulation methods
KW - Reaction Time physiology
KW - Acoustic Stimulation methods
KW - Decision Making
KW - Electric Stimulation methods
KW - Frontal Lobe blood supply
KW - Phonetics
KW - Transcranial Magnetic Stimulation methods
KW - Vocabulary
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Neuropsychological Tests
KW - Follow-Up Studies
KW - Oxygen blood
KW - Magnetic Resonance Imaging methods
KW - Analysis of Variance
KW - Brain Mapping
KW - Image Processing, Computer-Assisted methods
KW - Functional Laterality physiology
KW - Photic Stimulation methods
KW - Reaction Time physiology
KW - Acoustic Stimulation methods
KW - Decision Making
KW - Electric Stimulation methods
KW - Frontal Lobe blood supply
KW - Phonetics
KW - Transcranial Magnetic Stimulation methods
KW - Vocabulary
M3 - SCORING: Zeitschriftenaufsatz
VL - 48
SP - 3155
EP - 3163
JO - NEUROPSYCHOLOGIA
JF - NEUROPSYCHOLOGIA
SN - 0028-3932
IS - 10
M1 - 10
ER -
