PortalPublikationenThe Ret receptor regulates sensory neuron dendrite growth an...

The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion

Standard

The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. / Soba, Peter; Han, Chun; Zheng, Yi; Perea, Daniel; Miguel-Aliaga, Irene; Jan, Lily Yeh; Jan, Yuh Nung.

in: ELIFE, Jahrgang 4, 12.03.2015.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Soba, P, Han, C, Zheng, Y, Perea, D, Miguel-Aliaga, I, Jan, LY & Jan, YN 2015, 'The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion', ELIFE, Jg. 4. https://doi.org/10.7554/eLife.05491

APA

Soba, P., Han, C., Zheng, Y., Perea, D., Miguel-Aliaga, I., Jan, L. Y., & Jan, Y. N. (2015). The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. ELIFE, 4. https://doi.org/10.7554/eLife.05491

Vancouver

Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY et al. The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. ELIFE. 2015 Mär 12;4. https://doi.org/10.7554/eLife.05491

Bibtex

@article{9fbef804ad2a46ccb696403a3c580365,
title = "The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion",
abstract = "Neurons develop highly stereotyped receptive fields by coordinated growth of their dendrites. Although cell surface cues play a major role in this process, few dendrite specific signals have been identified to date. We conducted an in vivo RNAi screen in Drosophila class IV dendritic arborization (C4da) neurons and identified the conserved Ret receptor, known to play a role in axon guidance, as an important regulator of dendrite development. The loss of Ret results in severe dendrite defects due to loss of extracellular matrix adhesion, thus impairing growth within a 2D plane. We provide evidence that Ret interacts with integrins to regulate dendrite adhesion via rac1. In addition, Ret is required for dendrite stability and normal F-actin distribution suggesting it has an essential role in dendrite maintenance. We propose novel functions for Ret as a regulator in dendrite patterning and adhesion distinct from its role in axon guidance.",
author = "Peter Soba and Chun Han and Yi Zheng and Daniel Perea and Irene Miguel-Aliaga and Jan, {Lily Yeh} and Jan, {Yuh Nung}",
year = "2015",
month = mar,
day = "12",
doi = "10.7554/eLife.05491",
language = "English",
volume = "4",
journal = "ELIFE",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion

AU - Soba, Peter

AU - Han, Chun

AU - Zheng, Yi

AU - Perea, Daniel

AU - Miguel-Aliaga, Irene

AU - Jan, Lily Yeh

AU - Jan, Yuh Nung

PY - 2015/3/12

Y1 - 2015/3/12

N2 - Neurons develop highly stereotyped receptive fields by coordinated growth of their dendrites. Although cell surface cues play a major role in this process, few dendrite specific signals have been identified to date. We conducted an in vivo RNAi screen in Drosophila class IV dendritic arborization (C4da) neurons and identified the conserved Ret receptor, known to play a role in axon guidance, as an important regulator of dendrite development. The loss of Ret results in severe dendrite defects due to loss of extracellular matrix adhesion, thus impairing growth within a 2D plane. We provide evidence that Ret interacts with integrins to regulate dendrite adhesion via rac1. In addition, Ret is required for dendrite stability and normal F-actin distribution suggesting it has an essential role in dendrite maintenance. We propose novel functions for Ret as a regulator in dendrite patterning and adhesion distinct from its role in axon guidance.

AB - Neurons develop highly stereotyped receptive fields by coordinated growth of their dendrites. Although cell surface cues play a major role in this process, few dendrite specific signals have been identified to date. We conducted an in vivo RNAi screen in Drosophila class IV dendritic arborization (C4da) neurons and identified the conserved Ret receptor, known to play a role in axon guidance, as an important regulator of dendrite development. The loss of Ret results in severe dendrite defects due to loss of extracellular matrix adhesion, thus impairing growth within a 2D plane. We provide evidence that Ret interacts with integrins to regulate dendrite adhesion via rac1. In addition, Ret is required for dendrite stability and normal F-actin distribution suggesting it has an essential role in dendrite maintenance. We propose novel functions for Ret as a regulator in dendrite patterning and adhesion distinct from its role in axon guidance.

U2 - 10.7554/eLife.05491

DO - 10.7554/eLife.05491

M3 - SCORING: Journal article

C2 - 25764303

VL - 4

JO - ELIFE

JF - ELIFE

SN - 2050-084X

ER -