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The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease

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The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease. / Halsband, Claire; Zapf, Antonia; Sixel-Döring, Friederike; Trenkwalder, Claudia; Mollenhauer, Brit.

in: MOV DISORD CLIN PRAC, Jahrgang 5, Nr. 2, 17.07.2018, S. 171-176.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Halsband, C, Zapf, A, Sixel-Döring, F, Trenkwalder, C & Mollenhauer, B 2018, 'The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease', MOV DISORD CLIN PRAC, Jg. 5, Nr. 2, S. 171-176. https://doi.org/10.1002/mdc3.12591

APA

Halsband, C., Zapf, A., Sixel-Döring, F., Trenkwalder, C., & Mollenhauer, B. (2018). The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease. MOV DISORD CLIN PRAC, 5(2), 171-176. https://doi.org/10.1002/mdc3.12591

Vancouver

Halsband C, Zapf A, Sixel-Döring F, Trenkwalder C, Mollenhauer B. The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease. MOV DISORD CLIN PRAC. 2018 Jul 17;5(2):171-176. https://doi.org/10.1002/mdc3.12591

Bibtex

@article{5b474a9b42754fb4b43595676b5aa81e,
title = "The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease",
abstract = "Background: Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD).Objectives: To test the validity of the RBD-Screening Questionnaire (RBDSQ) in assessing RBD in early PD.Methods: The RBDSQ was completed before video-supported polysomnography (vPSG) by 134 de novo PD patients, 109 matched controls without neurological disorder (CTR) and 30 subjects with idiopathic RBD (iRBD) without clinical signs of PD; results were compared with vPSG-confirmed RBD diagnosis.Results and Conclusions: Sensitivity/specificity of the RBDSQ for the PD cohort were 0.44/0.84 at the previously published cut-off score of 6 for PD patients, and the area under the curve (AUC) 0.68 (95% CI, 0.56-0.79). By contrast, in the iRBD/CTR cohort the RBDSQ (cut-off = 5) had a sensitivity/specificity of 0.97/0.84 and an AUC of 0.95 (95% CI, 0.90-1.00). Subanalysis of question 6 only (4 subitems asking for dream enactment) at a cut-off score of 1 revealed a sensitivity of 0.74 and a specificity of 0.70 for the de novo PD cohort, AUC was 0.74 (95% CI, 0.63-0.84). RBDSQ is an insufficient screening tool for RBD in de novo PD. New screening tools for RBD assessment need to be developed.",
keywords = "Journal Article",
author = "Claire Halsband and Antonia Zapf and Friederike Sixel-D{\"o}ring and Claudia Trenkwalder and Brit Mollenhauer",
year = "2018",
month = jul,
day = "17",
doi = "10.1002/mdc3.12591",
language = "English",
volume = "5",
pages = "171--176",
journal = "MOV DISORD CLIN PRAC",
issn = "2330-1619",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease

AU - Halsband, Claire

AU - Zapf, Antonia

AU - Sixel-Döring, Friederike

AU - Trenkwalder, Claudia

AU - Mollenhauer, Brit

PY - 2018/7/17

Y1 - 2018/7/17

N2 - Background: Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD).Objectives: To test the validity of the RBD-Screening Questionnaire (RBDSQ) in assessing RBD in early PD.Methods: The RBDSQ was completed before video-supported polysomnography (vPSG) by 134 de novo PD patients, 109 matched controls without neurological disorder (CTR) and 30 subjects with idiopathic RBD (iRBD) without clinical signs of PD; results were compared with vPSG-confirmed RBD diagnosis.Results and Conclusions: Sensitivity/specificity of the RBDSQ for the PD cohort were 0.44/0.84 at the previously published cut-off score of 6 for PD patients, and the area under the curve (AUC) 0.68 (95% CI, 0.56-0.79). By contrast, in the iRBD/CTR cohort the RBDSQ (cut-off = 5) had a sensitivity/specificity of 0.97/0.84 and an AUC of 0.95 (95% CI, 0.90-1.00). Subanalysis of question 6 only (4 subitems asking for dream enactment) at a cut-off score of 1 revealed a sensitivity of 0.74 and a specificity of 0.70 for the de novo PD cohort, AUC was 0.74 (95% CI, 0.63-0.84). RBDSQ is an insufficient screening tool for RBD in de novo PD. New screening tools for RBD assessment need to be developed.

AB - Background: Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD).Objectives: To test the validity of the RBD-Screening Questionnaire (RBDSQ) in assessing RBD in early PD.Methods: The RBDSQ was completed before video-supported polysomnography (vPSG) by 134 de novo PD patients, 109 matched controls without neurological disorder (CTR) and 30 subjects with idiopathic RBD (iRBD) without clinical signs of PD; results were compared with vPSG-confirmed RBD diagnosis.Results and Conclusions: Sensitivity/specificity of the RBDSQ for the PD cohort were 0.44/0.84 at the previously published cut-off score of 6 for PD patients, and the area under the curve (AUC) 0.68 (95% CI, 0.56-0.79). By contrast, in the iRBD/CTR cohort the RBDSQ (cut-off = 5) had a sensitivity/specificity of 0.97/0.84 and an AUC of 0.95 (95% CI, 0.90-1.00). Subanalysis of question 6 only (4 subitems asking for dream enactment) at a cut-off score of 1 revealed a sensitivity of 0.74 and a specificity of 0.70 for the de novo PD cohort, AUC was 0.74 (95% CI, 0.63-0.84). RBDSQ is an insufficient screening tool for RBD in de novo PD. New screening tools for RBD assessment need to be developed.

KW - Journal Article

U2 - 10.1002/mdc3.12591

DO - 10.1002/mdc3.12591

M3 - SCORING: Journal article

C2 - 30009211

VL - 5

SP - 171

EP - 176

JO - MOV DISORD CLIN PRAC

JF - MOV DISORD CLIN PRAC

SN - 2330-1619

IS - 2

ER -