The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study
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The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study. / Ohlrogge, Amelie H; Brederecke, Jan; Ojeda, Francisco M; Pecha, Simon; Börschel, Christin S; Conradi, Lenard; Rimkus, Vanessa; Blankenberg, Stefan; Zeller, Tanja; Schnabel, Renate B.
in: FRONT NUTR, Jahrgang 9, 851005, 10.05.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study
AU - Ohlrogge, Amelie H
AU - Brederecke, Jan
AU - Ojeda, Francisco M
AU - Pecha, Simon
AU - Börschel, Christin S
AU - Conradi, Lenard
AU - Rimkus, Vanessa
AU - Blankenberg, Stefan
AU - Zeller, Tanja
AU - Schnabel, Renate B
N1 - Copyright © 2022 Ohlrogge, Brederecke, Ojeda, Pecha, Börschel, Conradi, Rimkus, Blankenberg, Zeller and Schnabel.
PY - 2022/5/10
Y1 - 2022/5/10
N2 - Background and Aims: The relationship between postoperative atrial fibrillation (POAF) and 25-hydroxyvitamin D [25(OH)D] concentration as well as vitamin D supplementation has been discussed controversially. The relation of pre-operative vitamin D status and POAF remains unclear.Methods and Results: We analysed the risk of POAF in a prospective, observational cohort study of n = 201 patients undergoing coronary artery bypass graft surgery (CABG) with 25(OH)D concentration. The median age was 66.6 years, 15.4% were women. The median (25th/75th percentile) vitamin D concentration at baseline was 17.7 (12.6/23.7) ng/ml. During follow-up we observed 48 cases of POAF. In age, sex, and creatinine-adjusted analyses, 25(OH)D was associated with an increased risk of POAF, though with borderline statistical significance [odds ratio (OR) 1.85, 95% confidence interval (CI) 0.87-3.92, p-value 0.107], in further risk factor-adjusted analyses the results remained stable (OR 1.99, 95% CI 0.90-4.39, p-value 0.087). The subgroup with vitamin D supplementation at baseline showed an increased risk of POAF (OR 5.03, 95% CI 1.13-22.33, p-value 0.034).Conclusion: In our contemporary mid-European cohort, higher 25(OH)D concentration did not show a benefit for POAF in CABG patients and may even be harmful, though with borderline statistical significance. Our data are in line with a recent randomised study in community-based adults and call for further research to determine both, the clinical impact of elevated 25(OH)D concentration and vitamin D supplementation as well as the possible underlying pathophysiological mechanisms.
AB - Background and Aims: The relationship between postoperative atrial fibrillation (POAF) and 25-hydroxyvitamin D [25(OH)D] concentration as well as vitamin D supplementation has been discussed controversially. The relation of pre-operative vitamin D status and POAF remains unclear.Methods and Results: We analysed the risk of POAF in a prospective, observational cohort study of n = 201 patients undergoing coronary artery bypass graft surgery (CABG) with 25(OH)D concentration. The median age was 66.6 years, 15.4% were women. The median (25th/75th percentile) vitamin D concentration at baseline was 17.7 (12.6/23.7) ng/ml. During follow-up we observed 48 cases of POAF. In age, sex, and creatinine-adjusted analyses, 25(OH)D was associated with an increased risk of POAF, though with borderline statistical significance [odds ratio (OR) 1.85, 95% confidence interval (CI) 0.87-3.92, p-value 0.107], in further risk factor-adjusted analyses the results remained stable (OR 1.99, 95% CI 0.90-4.39, p-value 0.087). The subgroup with vitamin D supplementation at baseline showed an increased risk of POAF (OR 5.03, 95% CI 1.13-22.33, p-value 0.034).Conclusion: In our contemporary mid-European cohort, higher 25(OH)D concentration did not show a benefit for POAF in CABG patients and may even be harmful, though with borderline statistical significance. Our data are in line with a recent randomised study in community-based adults and call for further research to determine both, the clinical impact of elevated 25(OH)D concentration and vitamin D supplementation as well as the possible underlying pathophysiological mechanisms.
U2 - 10.3389/fnut.2022.851005
DO - 10.3389/fnut.2022.851005
M3 - SCORING: Journal article
C2 - 35619954
VL - 9
JO - FRONT NUTR
JF - FRONT NUTR
SN - 2296-861X
M1 - 851005
ER -