The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.

Hüseyin Sirma; Mukesh Kumar; Jitendra K Meena; Britta Witt; Julia M Weise; Andre Lechel; Satyanarayana Ande; Vadim Sakk; Christiane Guguen-Guillouzo; Lars Zender; Karl-Lenhard Rudolph; Cagatay Günes

The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.

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The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. / Sirma, Hüseyin; Kumar, Mukesh; Meena, Jitendra K; Witt, Britta; Weise, Julia M; Lechel, Andre; Ande, Satyanarayana; Sakk, Vadim; Guguen-Guillouzo, Christiane; Zender, Lars; Rudolph, Karl-Lenhard; Günes, Cagatay.

in: GASTROENTEROLOGY, Jahrgang 141, Nr. 1, 1, 2011, S. 1-3, 326-337.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sirma, H, Kumar, M, Meena, JK, Witt, B, Weise, JM, Lechel, A, Ande, S, Sakk, V, Guguen-Guillouzo, C, Zender, L, Rudolph, K-L & Günes, C 2011, 'The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.', GASTROENTEROLOGY, Jg. 141, Nr. 1, 1, S. 1-3, 326-337. <http://www.ncbi.nlm.nih.gov/pubmed/21447332?dopt=Citation>

APA

Sirma, H., Kumar, M., Meena, J. K., Witt, B., Weise, J. M., Lechel, A., Ande, S., Sakk, V., Guguen-Guillouzo, C., Zender, L., Rudolph, K-L., & Günes, C. (2011). The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. GASTROENTEROLOGY, 141(1), 1-3, 326-337. [1]. http://www.ncbi.nlm.nih.gov/pubmed/21447332?dopt=Citation

Vancouver

Sirma H, Kumar M, Meena JK, Witt B, Weise JM, Lechel A et al. The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. GASTROENTEROLOGY. 2011;141(1):1-3, 326-337. 1.

Bibtex

@article{fc91f8569980472f89d4febbb78e8415,

title = "The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.",

abstract = "Telomerase activity has not been detected in healthy human liver biopsy samples, but it is up-regulated in most human liver tumors. It is not clear whether telomerase is activated in response to acute or chronic liver injury. Telomerase activity is closely associated with expression of its catalytic subunit, telomerase reverse transcriptase (TERT). We analyzed the activity of the human TERT (hTERT) promoter during liver regeneration in vivo and hepatocyte proliferation in vitro.",

keywords = "Animals, Humans, Male, Time Factors, Cells, Cultured, Mice, Mice, Inbred C57BL, Binding Sites, Mice, Transgenic, Cell Differentiation, Chromatin Immunoprecipitation, Genes, Reporter, *Cell Proliferation, RNA Interference, *Promoter Regions, Genetic, Gene Expression Regulation, Enzymologic, E2F2 Transcription Factor/metabolism, E2F7 Transcription Factor/metabolism, Hepatectomy, Hepatocytes/*enzymology, Lac Operon, Liver/*enzymology/surgery, *Liver Regeneration, Regulatory Elements, Transcriptional, Retinoblastoma Protein/metabolism, Telomerase/*genetics/metabolism, *Transcriptional Activation, Animals, Humans, Male, Time Factors, Cells, Cultured, Mice, Mice, Inbred C57BL, Binding Sites, Mice, Transgenic, Cell Differentiation, Chromatin Immunoprecipitation, Genes, Reporter, *Cell Proliferation, RNA Interference, *Promoter Regions, Genetic, Gene Expression Regulation, Enzymologic, E2F2 Transcription Factor/metabolism, E2F7 Transcription Factor/metabolism, Hepatectomy, Hepatocytes/*enzymology, Lac Operon, Liver/*enzymology/surgery, *Liver Regeneration, Regulatory Elements, Transcriptional, Retinoblastoma Protein/metabolism, Telomerase/*genetics/metabolism, *Transcriptional Activation",

author = "H{\"u}seyin Sirma and Mukesh Kumar and Meena, {Jitendra K} and Britta Witt and Weise, {Julia M} and Andre Lechel and Satyanarayana Ande and Vadim Sakk and Christiane Guguen-Guillouzo and Lars Zender and Karl-Lenhard Rudolph and Cagatay G{\"u}nes",

year = "2011",

language = "English",

volume = "141",

pages = "1--3, 326--337",

journal = "GASTROENTEROLOGY",

issn = "0016-5085",

publisher = "W.B. Saunders Ltd",

number = "1",

}

RIS

TY - JOUR

T1 - The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.

AU - Sirma, Hüseyin

AU - Kumar, Mukesh

AU - Meena, Jitendra K

AU - Witt, Britta

AU - Weise, Julia M

AU - Lechel, Andre

AU - Ande, Satyanarayana

AU - Sakk, Vadim

AU - Guguen-Guillouzo, Christiane

AU - Zender, Lars

AU - Rudolph, Karl-Lenhard

AU - Günes, Cagatay

PY - 2011

Y1 - 2011

N2 - Telomerase activity has not been detected in healthy human liver biopsy samples, but it is up-regulated in most human liver tumors. It is not clear whether telomerase is activated in response to acute or chronic liver injury. Telomerase activity is closely associated with expression of its catalytic subunit, telomerase reverse transcriptase (TERT). We analyzed the activity of the human TERT (hTERT) promoter during liver regeneration in vivo and hepatocyte proliferation in vitro.

AB - Telomerase activity has not been detected in healthy human liver biopsy samples, but it is up-regulated in most human liver tumors. It is not clear whether telomerase is activated in response to acute or chronic liver injury. Telomerase activity is closely associated with expression of its catalytic subunit, telomerase reverse transcriptase (TERT). We analyzed the activity of the human TERT (hTERT) promoter during liver regeneration in vivo and hepatocyte proliferation in vitro.

KW - Animals

KW - Humans

KW - Male

KW - Time Factors

KW - Cells, Cultured

KW - Mice

KW - Mice, Inbred C57BL

KW - Binding Sites

KW - Mice, Transgenic

KW - Cell Differentiation

KW - Chromatin Immunoprecipitation

KW - Genes, Reporter

KW - Cell Proliferation

KW - RNA Interference

KW - Promoter Regions, Genetic

KW - Gene Expression Regulation, Enzymologic

KW - E2F2 Transcription Factor/metabolism

KW - E2F7 Transcription Factor/metabolism

KW - Hepatectomy

KW - Hepatocytes/enzymology

KW - Lac Operon

KW - Liver/enzymology/surgery

KW - Liver Regeneration

KW - Regulatory Elements, Transcriptional

KW - Retinoblastoma Protein/metabolism

KW - Telomerase/genetics/metabolism

KW - Transcriptional Activation