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The Prevalence of Sickle Cell Disease and Its Implication for Newborn Screening in Germany (Hamburg Metropolitan Area)

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The Prevalence of Sickle Cell Disease and Its Implication for Newborn Screening in Germany (Hamburg Metropolitan Area). / Grosse, Regine; Lukacs, Zoltan; Cobos, Paulina Nieves; Oyen, Florian; Ehmen, Christa; Muntau, Birgit; Timmann, Christian; Noack, Bernd.

in: PEDIATR BLOOD CANCER, Jahrgang 63, Nr. 1, 01.2016, S. 168-70.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Grosse, R, Lukacs, Z, Cobos, PN, Oyen, F, Ehmen, C, Muntau, B, Timmann, C & Noack, B 2016, 'The Prevalence of Sickle Cell Disease and Its Implication for Newborn Screening in Germany (Hamburg Metropolitan Area)', PEDIATR BLOOD CANCER, Jg. 63, Nr. 1, S. 168-70. https://doi.org/10.1002/pbc.25706

APA

Grosse, R., Lukacs, Z., Cobos, P. N., Oyen, F., Ehmen, C., Muntau, B., Timmann, C., & Noack, B. (2016). The Prevalence of Sickle Cell Disease and Its Implication for Newborn Screening in Germany (Hamburg Metropolitan Area). PEDIATR BLOOD CANCER, 63(1), 168-70. https://doi.org/10.1002/pbc.25706

Vancouver

Grosse R, Lukacs Z, Cobos PN, Oyen F, Ehmen C, Muntau B et al. The Prevalence of Sickle Cell Disease and Its Implication for Newborn Screening in Germany (Hamburg Metropolitan Area). PEDIATR BLOOD CANCER. 2016 Jan;63(1):168-70. https://doi.org/10.1002/pbc.25706

Bibtex

@article{85e6c787dcfa4643b4986a188b6c3846,
title = "The Prevalence of Sickle Cell Disease and Its Implication for Newborn Screening in Germany (Hamburg Metropolitan Area)",
abstract = "Sickle cell disease is among hereditary diseases with evidence that early diagnoses and treatment improves the clinical outcome. So far sickle cell disease has not been included in the German newborn screening program despite immigration from countries with populations at risk. To determine the birth prevalence we tested 17,018 newborns. High pressure liquid chromatography and subsequent molecular-genetic testing were used for the detection and confirmation of hemoglobin variants. The frequency of sickle cell disease-consistent genotypes was one in 2,385 newborns. Duffy-blood group typing showed evidence that affected children were likely of Sub-Saharan ancestry. An inclusion of sickle cell disease into the German newborn screening seems reasonable.",
keywords = "Anemia, Sickle Cell, Genotype, Germany, Humans, Infant, Newborn, Neonatal Screening, Prevalence, Journal Article, Research Support, Non-U.S. Gov't",
author = "Regine Grosse and Zoltan Lukacs and Cobos, {Paulina Nieves} and Florian Oyen and Christa Ehmen and Birgit Muntau and Christian Timmann and Bernd Noack",
note = "{\textcopyright} 2015 Wiley Periodicals, Inc.",
year = "2016",
month = jan,
doi = "10.1002/pbc.25706",
language = "English",
volume = "63",
pages = "168--70",
journal = "PEDIATR BLOOD CANCER",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - The Prevalence of Sickle Cell Disease and Its Implication for Newborn Screening in Germany (Hamburg Metropolitan Area)

AU - Grosse, Regine

AU - Lukacs, Zoltan

AU - Cobos, Paulina Nieves

AU - Oyen, Florian

AU - Ehmen, Christa

AU - Muntau, Birgit

AU - Timmann, Christian

AU - Noack, Bernd

N1 - © 2015 Wiley Periodicals, Inc.

PY - 2016/1

Y1 - 2016/1

N2 - Sickle cell disease is among hereditary diseases with evidence that early diagnoses and treatment improves the clinical outcome. So far sickle cell disease has not been included in the German newborn screening program despite immigration from countries with populations at risk. To determine the birth prevalence we tested 17,018 newborns. High pressure liquid chromatography and subsequent molecular-genetic testing were used for the detection and confirmation of hemoglobin variants. The frequency of sickle cell disease-consistent genotypes was one in 2,385 newborns. Duffy-blood group typing showed evidence that affected children were likely of Sub-Saharan ancestry. An inclusion of sickle cell disease into the German newborn screening seems reasonable.

AB - Sickle cell disease is among hereditary diseases with evidence that early diagnoses and treatment improves the clinical outcome. So far sickle cell disease has not been included in the German newborn screening program despite immigration from countries with populations at risk. To determine the birth prevalence we tested 17,018 newborns. High pressure liquid chromatography and subsequent molecular-genetic testing were used for the detection and confirmation of hemoglobin variants. The frequency of sickle cell disease-consistent genotypes was one in 2,385 newborns. Duffy-blood group typing showed evidence that affected children were likely of Sub-Saharan ancestry. An inclusion of sickle cell disease into the German newborn screening seems reasonable.

KW - Anemia, Sickle Cell

KW - Genotype

KW - Germany

KW - Humans

KW - Infant, Newborn

KW - Neonatal Screening

KW - Prevalence

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/pbc.25706

DO - 10.1002/pbc.25706

M3 - SCORING: Journal article

C2 - 26275168

VL - 63

SP - 168

EP - 170

JO - PEDIATR BLOOD CANCER

JF - PEDIATR BLOOD CANCER

SN - 1545-5009

IS - 1

ER -