The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward.

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The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward. / Ortibus, Els; Lopriore, Enrico; Deprest, Jan; Vandenbussche, Frank P; Walther, Frans J; Diemert, Anke; Hecher, Kurt; Lagae, Lieven; Paul, De Cock; Lewi, Paul J; Lewi, Liesbeth.

in: AM J OBSTET GYNECOL, Jahrgang 200, Nr. 5, 5, 2009, S. 1-8.

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@article{865b735b544d4558a37c1335469e335f,
title = "The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward.",
abstract = "OBJECTIVES: We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment. STUDY DESIGN: We conducted a prospective cohort study of 136 monochorionic twins followed up from the first trimester until infancy. RESULTS: A total of 122 (90%) pregnancies resulted in 2 survivors, 6 (4%) in 1 survivor and 8 (6%) in no survivor. In all, 230 (92%) of 250 surviving infants were assessed at a mean age of 24 months. Neurodevelopmental impairment was present in 22 (10%) infants. Death or impairment of 1 or both infants occurred in 28 (22%) of 126 pregnancies. Twin-to-twin transfusion syndrome and assisted conception increased the risk of both death and impairment, whereas early-onset discordant growth only increased the risk of death. CONCLUSION: The mortality in this prospective series was 8% and neurodevelopmental impairment occurred in 10% of infants.",
author = "Els Ortibus and Enrico Lopriore and Jan Deprest and Vandenbussche, {Frank P} and Walther, {Frans J} and Anke Diemert and Kurt Hecher and Lieven Lagae and Paul, {De Cock} and Lewi, {Paul J} and Liesbeth Lewi",
year = "2009",
language = "Deutsch",
volume = "200",
pages = "1--8",
journal = "AM J OBSTET GYNECOL",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward.

AU - Ortibus, Els

AU - Lopriore, Enrico

AU - Deprest, Jan

AU - Vandenbussche, Frank P

AU - Walther, Frans J

AU - Diemert, Anke

AU - Hecher, Kurt

AU - Lagae, Lieven

AU - Paul, De Cock

AU - Lewi, Paul J

AU - Lewi, Liesbeth

PY - 2009

Y1 - 2009

N2 - OBJECTIVES: We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment. STUDY DESIGN: We conducted a prospective cohort study of 136 monochorionic twins followed up from the first trimester until infancy. RESULTS: A total of 122 (90%) pregnancies resulted in 2 survivors, 6 (4%) in 1 survivor and 8 (6%) in no survivor. In all, 230 (92%) of 250 surviving infants were assessed at a mean age of 24 months. Neurodevelopmental impairment was present in 22 (10%) infants. Death or impairment of 1 or both infants occurred in 28 (22%) of 126 pregnancies. Twin-to-twin transfusion syndrome and assisted conception increased the risk of both death and impairment, whereas early-onset discordant growth only increased the risk of death. CONCLUSION: The mortality in this prospective series was 8% and neurodevelopmental impairment occurred in 10% of infants.

AB - OBJECTIVES: We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment. STUDY DESIGN: We conducted a prospective cohort study of 136 monochorionic twins followed up from the first trimester until infancy. RESULTS: A total of 122 (90%) pregnancies resulted in 2 survivors, 6 (4%) in 1 survivor and 8 (6%) in no survivor. In all, 230 (92%) of 250 surviving infants were assessed at a mean age of 24 months. Neurodevelopmental impairment was present in 22 (10%) infants. Death or impairment of 1 or both infants occurred in 28 (22%) of 126 pregnancies. Twin-to-twin transfusion syndrome and assisted conception increased the risk of both death and impairment, whereas early-onset discordant growth only increased the risk of death. CONCLUSION: The mortality in this prospective series was 8% and neurodevelopmental impairment occurred in 10% of infants.

M3 - SCORING: Zeitschriftenaufsatz

VL - 200

SP - 1

EP - 8

JO - AM J OBSTET GYNECOL

JF - AM J OBSTET GYNECOL

SN - 0002-9378

IS - 5

M1 - 5

ER -