The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward.
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The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward. / Ortibus, Els; Lopriore, Enrico; Deprest, Jan; Vandenbussche, Frank P; Walther, Frans J; Diemert, Anke; Hecher, Kurt; Lagae, Lieven; Paul, De Cock; Lewi, Paul J; Lewi, Liesbeth.
in: AM J OBSTET GYNECOL, Jahrgang 200, Nr. 5, 5, 2009, S. 1-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward.
AU - Ortibus, Els
AU - Lopriore, Enrico
AU - Deprest, Jan
AU - Vandenbussche, Frank P
AU - Walther, Frans J
AU - Diemert, Anke
AU - Hecher, Kurt
AU - Lagae, Lieven
AU - Paul, De Cock
AU - Lewi, Paul J
AU - Lewi, Liesbeth
PY - 2009
Y1 - 2009
N2 - OBJECTIVES: We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment. STUDY DESIGN: We conducted a prospective cohort study of 136 monochorionic twins followed up from the first trimester until infancy. RESULTS: A total of 122 (90%) pregnancies resulted in 2 survivors, 6 (4%) in 1 survivor and 8 (6%) in no survivor. In all, 230 (92%) of 250 surviving infants were assessed at a mean age of 24 months. Neurodevelopmental impairment was present in 22 (10%) infants. Death or impairment of 1 or both infants occurred in 28 (22%) of 126 pregnancies. Twin-to-twin transfusion syndrome and assisted conception increased the risk of both death and impairment, whereas early-onset discordant growth only increased the risk of death. CONCLUSION: The mortality in this prospective series was 8% and neurodevelopmental impairment occurred in 10% of infants.
AB - OBJECTIVES: We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment. STUDY DESIGN: We conducted a prospective cohort study of 136 monochorionic twins followed up from the first trimester until infancy. RESULTS: A total of 122 (90%) pregnancies resulted in 2 survivors, 6 (4%) in 1 survivor and 8 (6%) in no survivor. In all, 230 (92%) of 250 surviving infants were assessed at a mean age of 24 months. Neurodevelopmental impairment was present in 22 (10%) infants. Death or impairment of 1 or both infants occurred in 28 (22%) of 126 pregnancies. Twin-to-twin transfusion syndrome and assisted conception increased the risk of both death and impairment, whereas early-onset discordant growth only increased the risk of death. CONCLUSION: The mortality in this prospective series was 8% and neurodevelopmental impairment occurred in 10% of infants.
M3 - SCORING: Zeitschriftenaufsatz
VL - 200
SP - 1
EP - 8
JO - AM J OBSTET GYNECOL
JF - AM J OBSTET GYNECOL
SN - 0002-9378
IS - 5
M1 - 5
ER -