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The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers

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The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers. / Hughes, Maria F; Patterson, Christopher C; Appleton, Katherine M; Blankenberg, Stefan; Woodside, Jayne V; Donnelly, Michael; Linden, Gerard; Zeller, Tanja; Esquirol, Yolande; Kee, Frank.

in: PSYCHOSOM MED, Jahrgang 78, Nr. 4, 05.2016, S. 401-411.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hughes, MF, Patterson, CC, Appleton, KM, Blankenberg, S, Woodside, JV, Donnelly, M, Linden, G, Zeller, T, Esquirol, Y & Kee, F 2016, 'The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers', PSYCHOSOM MED, Jg. 78, Nr. 4, S. 401-411. https://doi.org/10.1097/PSY.0000000000000289

APA

Hughes, M. F., Patterson, C. C., Appleton, K. M., Blankenberg, S., Woodside, J. V., Donnelly, M., Linden, G., Zeller, T., Esquirol, Y., & Kee, F. (2016). The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers. PSYCHOSOM MED, 78(4), 401-411. https://doi.org/10.1097/PSY.0000000000000289

Vancouver

Hughes MF, Patterson CC, Appleton KM, Blankenberg S, Woodside JV, Donnelly M et al. The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers. PSYCHOSOM MED. 2016 Mai;78(4):401-411. https://doi.org/10.1097/PSY.0000000000000289

Bibtex

@article{4796299cf4e1416fa998f6429ff9e25d,
title = "The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers",
abstract = "OBJECTIVES: To improve understanding about the potential underlying biological mechanisms in the link between depression and all-cause mortality and to investigate the role that inflammatory and other cardiovascular risk factors may play in the relationship between depressive symptoms and mortality.METHODS: Depression and blood-based biological markers were assessed in the Belfast PRIME prospective cohort study (N = 2389 men, aged 50-59 years) in which participants were followed up for 18 years. Depression was measured using the 10-item Welsh Pure Depression Inventory. Inflammation markers (C-reactive protein [CRP], neopterin, interleukin [IL]-1 receptor antagonist [IL-1Ra], and IL-18) and cardiovascular-specific risk factors (N-terminal pro-b-type natriuretic peptide, midregion pro-atrial natriuretic peptide, midregion pro-adrenomedullin, C-terminal pro-endothelin-1 [CT-proET]) were obtained at baseline. We used Cox proportional hazards modeling to examine the association between depression and biological measures in relation to all-cause mortality and explore the mediating effects.RESULTS: During follow-up, 418 participants died. Higher levels of depressive symptoms were associated with higher levels of CRP, IL-1Ra, and CT-proET. After adjustment for socioeconomic and life-style risk factors, depressive symptoms were significantly associated with all-cause mortality (hazard ratio = 1.10 per scale unit, 95% confidence interval = 1.04-1.16). This association was partly explained by CRP (7.3%) suggesting a minimal mediation effect. IL-1Ra, N-terminal pro-b-type natriuretic peptide, midregion pro-atrial natriuretic peptide, midregion pro-adrenomedullin, and CT-proET contributed marginally to the association between depression and subsequent mortality.CONCLUSIONS: Inflammatory and cardiovascular risk markers are associated with depression and with increased mortality. However, depression and biological measures show additive effects rather than a pattern of meditation of biological factors in the association between depression and mortality.",
keywords = "Biomarkers/blood, Cardiovascular Diseases/blood, Cause of Death, Depression/epidemiology, Follow-Up Studies, Humans, Inflammation/blood, Male, Middle Aged, Northern Ireland/epidemiology, Prognosis",
author = "Hughes, {Maria F} and Patterson, {Christopher C} and Appleton, {Katherine M} and Stefan Blankenberg and Woodside, {Jayne V} and Michael Donnelly and Gerard Linden and Tanja Zeller and Yolande Esquirol and Frank Kee",
year = "2016",
month = may,
doi = "10.1097/PSY.0000000000000289",
language = "English",
volume = "78",
pages = "401--411",
journal = "PSYCHOSOM MED",
issn = "0033-3174",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - The Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers

AU - Hughes, Maria F

AU - Patterson, Christopher C

AU - Appleton, Katherine M

AU - Blankenberg, Stefan

AU - Woodside, Jayne V

AU - Donnelly, Michael

AU - Linden, Gerard

AU - Zeller, Tanja

AU - Esquirol, Yolande

AU - Kee, Frank

PY - 2016/5

Y1 - 2016/5

N2 - OBJECTIVES: To improve understanding about the potential underlying biological mechanisms in the link between depression and all-cause mortality and to investigate the role that inflammatory and other cardiovascular risk factors may play in the relationship between depressive symptoms and mortality.METHODS: Depression and blood-based biological markers were assessed in the Belfast PRIME prospective cohort study (N = 2389 men, aged 50-59 years) in which participants were followed up for 18 years. Depression was measured using the 10-item Welsh Pure Depression Inventory. Inflammation markers (C-reactive protein [CRP], neopterin, interleukin [IL]-1 receptor antagonist [IL-1Ra], and IL-18) and cardiovascular-specific risk factors (N-terminal pro-b-type natriuretic peptide, midregion pro-atrial natriuretic peptide, midregion pro-adrenomedullin, C-terminal pro-endothelin-1 [CT-proET]) were obtained at baseline. We used Cox proportional hazards modeling to examine the association between depression and biological measures in relation to all-cause mortality and explore the mediating effects.RESULTS: During follow-up, 418 participants died. Higher levels of depressive symptoms were associated with higher levels of CRP, IL-1Ra, and CT-proET. After adjustment for socioeconomic and life-style risk factors, depressive symptoms were significantly associated with all-cause mortality (hazard ratio = 1.10 per scale unit, 95% confidence interval = 1.04-1.16). This association was partly explained by CRP (7.3%) suggesting a minimal mediation effect. IL-1Ra, N-terminal pro-b-type natriuretic peptide, midregion pro-atrial natriuretic peptide, midregion pro-adrenomedullin, and CT-proET contributed marginally to the association between depression and subsequent mortality.CONCLUSIONS: Inflammatory and cardiovascular risk markers are associated with depression and with increased mortality. However, depression and biological measures show additive effects rather than a pattern of meditation of biological factors in the association between depression and mortality.

AB - OBJECTIVES: To improve understanding about the potential underlying biological mechanisms in the link between depression and all-cause mortality and to investigate the role that inflammatory and other cardiovascular risk factors may play in the relationship between depressive symptoms and mortality.METHODS: Depression and blood-based biological markers were assessed in the Belfast PRIME prospective cohort study (N = 2389 men, aged 50-59 years) in which participants were followed up for 18 years. Depression was measured using the 10-item Welsh Pure Depression Inventory. Inflammation markers (C-reactive protein [CRP], neopterin, interleukin [IL]-1 receptor antagonist [IL-1Ra], and IL-18) and cardiovascular-specific risk factors (N-terminal pro-b-type natriuretic peptide, midregion pro-atrial natriuretic peptide, midregion pro-adrenomedullin, C-terminal pro-endothelin-1 [CT-proET]) were obtained at baseline. We used Cox proportional hazards modeling to examine the association between depression and biological measures in relation to all-cause mortality and explore the mediating effects.RESULTS: During follow-up, 418 participants died. Higher levels of depressive symptoms were associated with higher levels of CRP, IL-1Ra, and CT-proET. After adjustment for socioeconomic and life-style risk factors, depressive symptoms were significantly associated with all-cause mortality (hazard ratio = 1.10 per scale unit, 95% confidence interval = 1.04-1.16). This association was partly explained by CRP (7.3%) suggesting a minimal mediation effect. IL-1Ra, N-terminal pro-b-type natriuretic peptide, midregion pro-atrial natriuretic peptide, midregion pro-adrenomedullin, and CT-proET contributed marginally to the association between depression and subsequent mortality.CONCLUSIONS: Inflammatory and cardiovascular risk markers are associated with depression and with increased mortality. However, depression and biological measures show additive effects rather than a pattern of meditation of biological factors in the association between depression and mortality.

KW - Biomarkers/blood

KW - Cardiovascular Diseases/blood

KW - Cause of Death

KW - Depression/epidemiology

KW - Follow-Up Studies

KW - Humans

KW - Inflammation/blood

KW - Male

KW - Middle Aged

KW - Northern Ireland/epidemiology

KW - Prognosis

U2 - 10.1097/PSY.0000000000000289

DO - 10.1097/PSY.0000000000000289

M3 - SCORING: Journal article

C2 - 26761713

VL - 78

SP - 401

EP - 411

JO - PSYCHOSOM MED

JF - PSYCHOSOM MED

SN - 0033-3174

IS - 4

ER -