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The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response

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The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response. / Schwarzenbach, Heidi.

in: EXPERT REV MOL DIAGN, Jahrgang 15, Nr. 2, 02.2015, S. 267-75.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schwarzenbach, H 2015, 'The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response', EXPERT REV MOL DIAGN, Jg. 15, Nr. 2, S. 267-75. https://doi.org/10.1586/14737159.2015.980817

APA

Schwarzenbach, H. (2015). The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response. EXPERT REV MOL DIAGN, 15(2), 267-75. https://doi.org/10.1586/14737159.2015.980817

Vancouver

Schwarzenbach H. The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response. EXPERT REV MOL DIAGN. 2015 Feb;15(2):267-75. https://doi.org/10.1586/14737159.2015.980817

Bibtex

@article{c66916d849ac4b76812679c53bc53511,
title = "The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response",
abstract = "An effective personalized medicine is associated with the ability of identifying cancer patients who respond to anticancer targeted therapies. Therefore, new companion biomarkers that facilitate drug development are urgently needed. Since clinically relevant genetic and epigenetic alterations can be detected in cell-free nucleic acids in the blood circulation of cancer patients, these molecules may be a new promising class of potential liquid biomarkers. They can be obtained in real-time from blood, and their analyses could, consequently, facilitate treatment decisions. Screening of these liquid biopsies may provide information on the aberrant signaling pathway that should be blocked by the chosen targeted therapy. This article will discuss the potential of circulating nucleic acids as therapeutics for overcoming chemotherapeutic resistance in anticancer strategies.",
author = "Heidi Schwarzenbach",
year = "2015",
month = feb,
doi = "10.1586/14737159.2015.980817",
language = "English",
volume = "15",
pages = "267--75",
journal = "EXPERT REV MOL DIAGN",
issn = "1473-7159",
publisher = "Expert Reviews Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response

AU - Schwarzenbach, Heidi

PY - 2015/2

Y1 - 2015/2

N2 - An effective personalized medicine is associated with the ability of identifying cancer patients who respond to anticancer targeted therapies. Therefore, new companion biomarkers that facilitate drug development are urgently needed. Since clinically relevant genetic and epigenetic alterations can be detected in cell-free nucleic acids in the blood circulation of cancer patients, these molecules may be a new promising class of potential liquid biomarkers. They can be obtained in real-time from blood, and their analyses could, consequently, facilitate treatment decisions. Screening of these liquid biopsies may provide information on the aberrant signaling pathway that should be blocked by the chosen targeted therapy. This article will discuss the potential of circulating nucleic acids as therapeutics for overcoming chemotherapeutic resistance in anticancer strategies.

AB - An effective personalized medicine is associated with the ability of identifying cancer patients who respond to anticancer targeted therapies. Therefore, new companion biomarkers that facilitate drug development are urgently needed. Since clinically relevant genetic and epigenetic alterations can be detected in cell-free nucleic acids in the blood circulation of cancer patients, these molecules may be a new promising class of potential liquid biomarkers. They can be obtained in real-time from blood, and their analyses could, consequently, facilitate treatment decisions. Screening of these liquid biopsies may provide information on the aberrant signaling pathway that should be blocked by the chosen targeted therapy. This article will discuss the potential of circulating nucleic acids as therapeutics for overcoming chemotherapeutic resistance in anticancer strategies.

U2 - 10.1586/14737159.2015.980817

DO - 10.1586/14737159.2015.980817

M3 - SCORING: Journal article

C2 - 25382372

VL - 15

SP - 267

EP - 275

JO - EXPERT REV MOL DIAGN

JF - EXPERT REV MOL DIAGN

SN - 1473-7159

IS - 2

ER -