PortalPublikationenThe polysialic acid mimetics 5-nonyloxytryptamine and vinore...

The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair

Standard

The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair. / Saini, Vedangana ; Lutz, David; Kataria, Hardeep; Kaur, Gurcharan; Schachner, Melitta; Loers, Gabriele.

in: SCI REP-UK, Jahrgang 6, 21.06.2016, S. 1-12.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Saini, V, Lutz, D, Kataria, H, Kaur, G, Schachner, M & Loers, G 2016, 'The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair', SCI REP-UK, Jg. 6, S. 1-12. https://doi.org/doi: 10.1038/srep26927

APA

Saini, V., Lutz, D., Kataria, H., Kaur, G., Schachner, M., & Loers, G. (2016). The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair. SCI REP-UK, 6, 1-12. https://doi.org/doi: 10.1038/srep26927

Vancouver

Saini V, Lutz D, Kataria H, Kaur G, Schachner M, Loers G. The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair. SCI REP-UK. 2016 Jun 21;6:1-12. https://doi.org/doi: 10.1038/srep26927

Bibtex

@article{672a28975f03477fa6ce0eebdb076879,
title = "The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair",
abstract = "Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell adhesion molecule (NCAM). Several studies have shown that it is important for correct formation of brain circuitries during development and for synaptic plasticity, learning and memory in the adult. PSA also plays a major role in nervous system regeneration following injury. As a next step for clinical translation of PSA based therapeutics, we have previously identified the small organic compounds 5-nonyloxytryptamine and vinorelbine as PSA mimetics. Activity of 5-nonyloxytryptamine and vinorelbine had been confirmed in assays with neural cells from the central and peripheral nervous system in vitro and shown to be independent of their function as serotonin receptor 5-HT1B/1D agonist or cytostatic drug, respectively. As we show here in an in vivo paradigm for spinal cord injury in mice, 5-nonyloxytryptamine and vinorelbine enhance regain of motor functions, axonal regrowth, motor neuron survival and remyelination. These data indicate that 5-nonyloxytryptamine and vinorelbine may be re-tasked from their current usage as a 5-HT1B/1D agonist or cytostatic drug to act as mimetics for PSA to stimulate regeneration after injury in the mammalian nervous system.",
author = "Vedangana Saini and David Lutz and Hardeep Kataria and Gurcharan Kaur and Melitta Schachner and Gabriele Loers",
year = "2016",
month = jun,
day = "21",
doi = "doi: 10.1038/srep26927",
language = "English",
volume = "6",
pages = "1--12",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair

AU - Saini, Vedangana

AU - Lutz, David

AU - Kataria, Hardeep

AU - Kaur, Gurcharan

AU - Schachner, Melitta

AU - Loers, Gabriele

PY - 2016/6/21

Y1 - 2016/6/21

N2 - Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell adhesion molecule (NCAM). Several studies have shown that it is important for correct formation of brain circuitries during development and for synaptic plasticity, learning and memory in the adult. PSA also plays a major role in nervous system regeneration following injury. As a next step for clinical translation of PSA based therapeutics, we have previously identified the small organic compounds 5-nonyloxytryptamine and vinorelbine as PSA mimetics. Activity of 5-nonyloxytryptamine and vinorelbine had been confirmed in assays with neural cells from the central and peripheral nervous system in vitro and shown to be independent of their function as serotonin receptor 5-HT1B/1D agonist or cytostatic drug, respectively. As we show here in an in vivo paradigm for spinal cord injury in mice, 5-nonyloxytryptamine and vinorelbine enhance regain of motor functions, axonal regrowth, motor neuron survival and remyelination. These data indicate that 5-nonyloxytryptamine and vinorelbine may be re-tasked from their current usage as a 5-HT1B/1D agonist or cytostatic drug to act as mimetics for PSA to stimulate regeneration after injury in the mammalian nervous system.

AB - Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell adhesion molecule (NCAM). Several studies have shown that it is important for correct formation of brain circuitries during development and for synaptic plasticity, learning and memory in the adult. PSA also plays a major role in nervous system regeneration following injury. As a next step for clinical translation of PSA based therapeutics, we have previously identified the small organic compounds 5-nonyloxytryptamine and vinorelbine as PSA mimetics. Activity of 5-nonyloxytryptamine and vinorelbine had been confirmed in assays with neural cells from the central and peripheral nervous system in vitro and shown to be independent of their function as serotonin receptor 5-HT1B/1D agonist or cytostatic drug, respectively. As we show here in an in vivo paradigm for spinal cord injury in mice, 5-nonyloxytryptamine and vinorelbine enhance regain of motor functions, axonal regrowth, motor neuron survival and remyelination. These data indicate that 5-nonyloxytryptamine and vinorelbine may be re-tasked from their current usage as a 5-HT1B/1D agonist or cytostatic drug to act as mimetics for PSA to stimulate regeneration after injury in the mammalian nervous system.

U2 - doi: 10.1038/srep26927

DO - doi: 10.1038/srep26927

M3 - SCORING: Journal article

C2 - 27324620

VL - 6

SP - 1

EP - 12

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -