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The placebo response in medicine: minimize, maximize or personalize?

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The placebo response in medicine: minimize, maximize or personalize? / Enck, Paul; Bingel, Ulrike; Schedlowski, Manfred; Rief, Winfried.

in: NAT REV DRUG DISCOV, Jahrgang 12, Nr. 3, 01.03.2013, S. 191-204.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Enck, P, Bingel, U, Schedlowski, M & Rief, W 2013, 'The placebo response in medicine: minimize, maximize or personalize?', NAT REV DRUG DISCOV, Jg. 12, Nr. 3, S. 191-204. https://doi.org/10.1038/nrd3923

APA

Enck, P., Bingel, U., Schedlowski, M., & Rief, W. (2013). The placebo response in medicine: minimize, maximize or personalize? NAT REV DRUG DISCOV, 12(3), 191-204. https://doi.org/10.1038/nrd3923

Vancouver

Enck P, Bingel U, Schedlowski M, Rief W. The placebo response in medicine: minimize, maximize or personalize? NAT REV DRUG DISCOV. 2013 Mär 1;12(3):191-204. https://doi.org/10.1038/nrd3923

Bibtex

@article{cd4c72a8e03043d3b2af0cbd03cc849e,
title = "The placebo response in medicine: minimize, maximize or personalize?",
abstract = "Our understanding of the mechanisms mediating or moderating the placebo response to medicines has grown substantially over the past decade and offers the opportunity to capitalize on its benefits in future drug development as well as in clinical practice. In this article, we discuss three strategies that could be used to modulate the placebo response, depending on which stage of the drug development process they are applied. In clinical trials the placebo effect should be minimized to optimize drug-placebo differences, thus ensuring that the efficacy of the investigational drug can be truly evaluated. Once the drug is approved and in clinical use, placebo effects should be maximized by harnessing patients' expectations and learning mechanisms to improve treatment outcomes. Finally, personalizing placebo responses - which involves considering an individual's genetic predisposition, personality, past medical history and treatment experience - could also maximize therapeutic outcomes.",
keywords = "Clinical Trials as Topic, Drug Design, Drug Discovery, Humans, Individualized Medicine, Physician-Patient Relations, Placebo Effect, Treatment Outcome",
author = "Paul Enck and Ulrike Bingel and Manfred Schedlowski and Winfried Rief",
year = "2013",
month = mar,
day = "1",
doi = "10.1038/nrd3923",
language = "English",
volume = "12",
pages = "191--204",
journal = "NAT REV DRUG DISCOV",
issn = "1474-1776",
publisher = "NATURE PUBLISHING GROUP",
number = "3",

}

RIS

TY - JOUR

T1 - The placebo response in medicine: minimize, maximize or personalize?

AU - Enck, Paul

AU - Bingel, Ulrike

AU - Schedlowski, Manfred

AU - Rief, Winfried

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Our understanding of the mechanisms mediating or moderating the placebo response to medicines has grown substantially over the past decade and offers the opportunity to capitalize on its benefits in future drug development as well as in clinical practice. In this article, we discuss three strategies that could be used to modulate the placebo response, depending on which stage of the drug development process they are applied. In clinical trials the placebo effect should be minimized to optimize drug-placebo differences, thus ensuring that the efficacy of the investigational drug can be truly evaluated. Once the drug is approved and in clinical use, placebo effects should be maximized by harnessing patients' expectations and learning mechanisms to improve treatment outcomes. Finally, personalizing placebo responses - which involves considering an individual's genetic predisposition, personality, past medical history and treatment experience - could also maximize therapeutic outcomes.

AB - Our understanding of the mechanisms mediating or moderating the placebo response to medicines has grown substantially over the past decade and offers the opportunity to capitalize on its benefits in future drug development as well as in clinical practice. In this article, we discuss three strategies that could be used to modulate the placebo response, depending on which stage of the drug development process they are applied. In clinical trials the placebo effect should be minimized to optimize drug-placebo differences, thus ensuring that the efficacy of the investigational drug can be truly evaluated. Once the drug is approved and in clinical use, placebo effects should be maximized by harnessing patients' expectations and learning mechanisms to improve treatment outcomes. Finally, personalizing placebo responses - which involves considering an individual's genetic predisposition, personality, past medical history and treatment experience - could also maximize therapeutic outcomes.

KW - Clinical Trials as Topic

KW - Drug Design

KW - Drug Discovery

KW - Humans

KW - Individualized Medicine

KW - Physician-Patient Relations

KW - Placebo Effect

KW - Treatment Outcome

U2 - 10.1038/nrd3923

DO - 10.1038/nrd3923

M3 - SCORING: Journal article

C2 - 23449306

VL - 12

SP - 191

EP - 204

JO - NAT REV DRUG DISCOV

JF - NAT REV DRUG DISCOV

SN - 1474-1776

IS - 3

ER -