PortalPublikationen[The pharmacokinetics of doxorubicin]

[The pharmacokinetics of doxorubicin]

Standard

[The pharmacokinetics of doxorubicin]. / Erttmann, Rudolf; Grandt, M; Erb, Norbert; Garbrecht, M; Landbeck, G.

in: KLIN PADIATR, Jahrgang 198, Nr. 3, 3, 1986, S. 271-276.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Erttmann, R, Grandt, M, Erb, N, Garbrecht, M & Landbeck, G 1986, '[The pharmacokinetics of doxorubicin]', KLIN PADIATR, Jg. 198, Nr. 3, 3, S. 271-276. <http://www.ncbi.nlm.nih.gov/pubmed/3723990?dopt=Citation>

APA

Erttmann, R., Grandt, M., Erb, N., Garbrecht, M., & Landbeck, G. (1986). [The pharmacokinetics of doxorubicin]. KLIN PADIATR, 198(3), 271-276. [3]. http://www.ncbi.nlm.nih.gov/pubmed/3723990?dopt=Citation

Vancouver

Erttmann R, Grandt M, Erb N, Garbrecht M, Landbeck G. [The pharmacokinetics of doxorubicin]. KLIN PADIATR. 1986;198(3):271-276. 3.

Bibtex

@article{88d1c9b646e74203bf1d5802c4af8a01,
title = "[The pharmacokinetics of doxorubicin]",
abstract = "Doxorubicin serum levels were measured with a highly specific reversed-phase HPLC-method in patients undergoing combination chemotherapy. Serum elimination kinetics of doxorubicin follow a bi- or triphasic first order pattern with a high interpatient variability. T 1/2 of the first distribution phase was 5.4 min. T 1/2 of the terminal steady-state elimination phase was 1273 min. After consecutive bolus application of 15 mg/m2 (4 times per 48 h) cumulation of doxorubicin was found in patient's serum. Serum levels 4 h after bolus injection of doxorubicin were found to be correlated with the area under the elimination curve. Therefore, 4 h serum levels after bolus injection can be used for clinical studies correlating pharmacokinetics with antineoplastic properties of doxorubicin.",
author = "Rudolf Erttmann and M Grandt and Norbert Erb and M Garbrecht and G Landbeck",
year = "1986",
language = "Deutsch",
volume = "198",
pages = "271--276",
journal = "KLIN PADIATR",
issn = "0300-8630",
publisher = "Georg Thieme Verlag KG",
number = "3",

}

RIS

TY - JOUR

T1 - [The pharmacokinetics of doxorubicin]

AU - Erttmann, Rudolf

AU - Grandt, M

AU - Erb, Norbert

AU - Garbrecht, M

AU - Landbeck, G

PY - 1986

Y1 - 1986

N2 - Doxorubicin serum levels were measured with a highly specific reversed-phase HPLC-method in patients undergoing combination chemotherapy. Serum elimination kinetics of doxorubicin follow a bi- or triphasic first order pattern with a high interpatient variability. T 1/2 of the first distribution phase was 5.4 min. T 1/2 of the terminal steady-state elimination phase was 1273 min. After consecutive bolus application of 15 mg/m2 (4 times per 48 h) cumulation of doxorubicin was found in patient's serum. Serum levels 4 h after bolus injection of doxorubicin were found to be correlated with the area under the elimination curve. Therefore, 4 h serum levels after bolus injection can be used for clinical studies correlating pharmacokinetics with antineoplastic properties of doxorubicin.

AB - Doxorubicin serum levels were measured with a highly specific reversed-phase HPLC-method in patients undergoing combination chemotherapy. Serum elimination kinetics of doxorubicin follow a bi- or triphasic first order pattern with a high interpatient variability. T 1/2 of the first distribution phase was 5.4 min. T 1/2 of the terminal steady-state elimination phase was 1273 min. After consecutive bolus application of 15 mg/m2 (4 times per 48 h) cumulation of doxorubicin was found in patient's serum. Serum levels 4 h after bolus injection of doxorubicin were found to be correlated with the area under the elimination curve. Therefore, 4 h serum levels after bolus injection can be used for clinical studies correlating pharmacokinetics with antineoplastic properties of doxorubicin.

M3 - SCORING: Zeitschriftenaufsatz

VL - 198

SP - 271

EP - 276

JO - KLIN PADIATR

JF - KLIN PADIATR

SN - 0300-8630

IS - 3

M1 - 3

ER -