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The nuclear lamina is a hub for the nuclear function of Jacob

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The nuclear lamina is a hub for the nuclear function of Jacob. / Samer, Sebastian; Raman, Rajeev; Laube, Gregor; Kreutz, Michael R; Karpova, Anna.

in: MOL BRAIN, Jahrgang 14, Nr. 1, 12.01.2021, S. 9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Samer, S, Raman, R, Laube, G, Kreutz, MR & Karpova, A 2021, 'The nuclear lamina is a hub for the nuclear function of Jacob', MOL BRAIN, Jg. 14, Nr. 1, S. 9. https://doi.org/10.1186/s13041-020-00722-1

APA

Samer, S., Raman, R., Laube, G., Kreutz, M. R., & Karpova, A. (2021). The nuclear lamina is a hub for the nuclear function of Jacob. MOL BRAIN, 14(1), 9. https://doi.org/10.1186/s13041-020-00722-1

Vancouver

Samer S, Raman R, Laube G, Kreutz MR, Karpova A. The nuclear lamina is a hub for the nuclear function of Jacob. MOL BRAIN. 2021 Jan 12;14(1):9. https://doi.org/10.1186/s13041-020-00722-1

Bibtex

@article{6f4e9a79b8194f38a9a0437f5a6732b0,
title = "The nuclear lamina is a hub for the nuclear function of Jacob",
abstract = "Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR activity and nuclear import. Immunogold electron microscopy and proximity ligation assay combined with STED imaging revealed preferential association of Jacob with the inner nuclear membrane where it directly binds to LaminB1, an intermediate filament and core component of the inner nuclear membrane (INM). The association with the INM is transient; it involves a functional nuclear export signal in Jacob and a canonical CRM1-RanGTP-dependent export mechanism that defines the residing time of the protein at the INM. Taken together, the data suggest a stepwise redistribution of Jacob within the nucleus following nuclear import and prior to nuclear export.",
author = "Sebastian Samer and Rajeev Raman and Gregor Laube and Kreutz, {Michael R} and Anna Karpova",
year = "2021",
month = jan,
day = "12",
doi = "10.1186/s13041-020-00722-1",
language = "English",
volume = "14",
pages = "9",
journal = "MOL BRAIN",
issn = "1756-6606",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - The nuclear lamina is a hub for the nuclear function of Jacob

AU - Samer, Sebastian

AU - Raman, Rajeev

AU - Laube, Gregor

AU - Kreutz, Michael R

AU - Karpova, Anna

PY - 2021/1/12

Y1 - 2021/1/12

N2 - Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR activity and nuclear import. Immunogold electron microscopy and proximity ligation assay combined with STED imaging revealed preferential association of Jacob with the inner nuclear membrane where it directly binds to LaminB1, an intermediate filament and core component of the inner nuclear membrane (INM). The association with the INM is transient; it involves a functional nuclear export signal in Jacob and a canonical CRM1-RanGTP-dependent export mechanism that defines the residing time of the protein at the INM. Taken together, the data suggest a stepwise redistribution of Jacob within the nucleus following nuclear import and prior to nuclear export.

AB - Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR activity and nuclear import. Immunogold electron microscopy and proximity ligation assay combined with STED imaging revealed preferential association of Jacob with the inner nuclear membrane where it directly binds to LaminB1, an intermediate filament and core component of the inner nuclear membrane (INM). The association with the INM is transient; it involves a functional nuclear export signal in Jacob and a canonical CRM1-RanGTP-dependent export mechanism that defines the residing time of the protein at the INM. Taken together, the data suggest a stepwise redistribution of Jacob within the nucleus following nuclear import and prior to nuclear export.

U2 - 10.1186/s13041-020-00722-1

DO - 10.1186/s13041-020-00722-1

M3 - SCORING: Journal article

C2 - 33436037

VL - 14

SP - 9

JO - MOL BRAIN

JF - MOL BRAIN

SN - 1756-6606

IS - 1

ER -