The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans.
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The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans. / Kalisch, Raffael; Holt, Beatrice; Petrovic, Predrag; Benedetto, De Martino; Klöppel, Stefan; Büchel, Christian; Dolan, Raymond J.
in: CEREB CORTEX, Jahrgang 19, Nr. 1, 1, 2009, S. 187-196.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans.
AU - Kalisch, Raffael
AU - Holt, Beatrice
AU - Petrovic, Predrag
AU - Benedetto, De Martino
AU - Klöppel, Stefan
AU - Büchel, Christian
AU - Dolan, Raymond J
PY - 2009
Y1 - 2009
N2 - Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycloserine (DCS) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (CS) at a memory test performed 72 h later. DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans.
AB - Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycloserine (DCS) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (CS) at a memory test performed 72 h later. DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans.
M3 - SCORING: Zeitschriftenaufsatz
VL - 19
SP - 187
EP - 196
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 1
M1 - 1
ER -
