The natural axis of transmitter receptor distribution in the human cerebral cortex
Standard
The natural axis of transmitter receptor distribution in the human cerebral cortex. / Goulas, Alexandros; Changeux, Jean-Pierre; Wagstyl, Konrad; Amunts, Katrin; Palomero-Gallagher, Nicola; Hilgetag, Claus C.
in: P NATL ACAD SCI USA, Jahrgang 118, Nr. 3, e2020574118, 19.01.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The natural axis of transmitter receptor distribution in the human cerebral cortex
AU - Goulas, Alexandros
AU - Changeux, Jean-Pierre
AU - Wagstyl, Konrad
AU - Amunts, Katrin
AU - Palomero-Gallagher, Nicola
AU - Hilgetag, Claus C
N1 - Copyright © 2021 the Author(s). Published by PNAS.
PY - 2021/1/19
Y1 - 2021/1/19
N2 - Transmitter receptors constitute a key component of the molecular machinery for intercellular communication in the brain. Recent efforts have mapped the density of diverse transmitter receptors across the human cerebral cortex with an unprecedented level of detail. Here, we distill these observations into key organizational principles. We demonstrate that receptor densities form a natural axis in the human cerebral cortex, reflecting decreases in differentiation at the level of laminar organization and a sensory-to-association axis at the functional level. Along this natural axis, key organizational principles are discerned: progressive molecular diversity (increase of the diversity of receptor density); excitation/inhibition (increase of the ratio of excitatory-to-inhibitory receptor density); and mirrored, orderly changes of the density of ionotropic and metabotropic receptors. The uncovered natural axis formed by the distribution of receptors aligns with the axis that is formed by other dimensions of cortical organization, such as the myelo- and cytoarchitectonic levels. Therefore, the uncovered natural axis constitutes a unifying organizational feature linking multiple dimensions of the cerebral cortex, thus bringing order to the heterogeneity of cortical organization.
AB - Transmitter receptors constitute a key component of the molecular machinery for intercellular communication in the brain. Recent efforts have mapped the density of diverse transmitter receptors across the human cerebral cortex with an unprecedented level of detail. Here, we distill these observations into key organizational principles. We demonstrate that receptor densities form a natural axis in the human cerebral cortex, reflecting decreases in differentiation at the level of laminar organization and a sensory-to-association axis at the functional level. Along this natural axis, key organizational principles are discerned: progressive molecular diversity (increase of the diversity of receptor density); excitation/inhibition (increase of the ratio of excitatory-to-inhibitory receptor density); and mirrored, orderly changes of the density of ionotropic and metabotropic receptors. The uncovered natural axis formed by the distribution of receptors aligns with the axis that is formed by other dimensions of cortical organization, such as the myelo- and cytoarchitectonic levels. Therefore, the uncovered natural axis constitutes a unifying organizational feature linking multiple dimensions of the cerebral cortex, thus bringing order to the heterogeneity of cortical organization.
U2 - 10.1073/pnas.2020574118
DO - 10.1073/pnas.2020574118
M3 - SCORING: Journal article
C2 - 33452137
VL - 118
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 3
M1 - e2020574118
ER -