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The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer

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The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer. / Rawnaq, Tamina; Dietrich, Luisa; Wolters-Eisfeld, Gerrit; Uzunoglu, Faik G; Vashist, Yogesh K; Bachmann, Kai; Simon, Ronald; Izbicki, Jakob R; Bockhorn, Maximilian; Güngör, Cenap.

in: MOL CANCER RES, Jahrgang 12, Nr. 5, 01.05.2014, S. 670-80.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rawnaq, T, Dietrich, L, Wolters-Eisfeld, G, Uzunoglu, FG, Vashist, YK, Bachmann, K, Simon, R, Izbicki, JR, Bockhorn, M & Güngör, C 2014, 'The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer', MOL CANCER RES, Jg. 12, Nr. 5, S. 670-80. https://doi.org/10.1158/1541-7786.MCR-13-0467

APA

Rawnaq, T., Dietrich, L., Wolters-Eisfeld, G., Uzunoglu, F. G., Vashist, Y. K., Bachmann, K., Simon, R., Izbicki, J. R., Bockhorn, M., & Güngör, C. (2014). The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer. MOL CANCER RES, 12(5), 670-80. https://doi.org/10.1158/1541-7786.MCR-13-0467

Vancouver

Rawnaq T, Dietrich L, Wolters-Eisfeld G, Uzunoglu FG, Vashist YK, Bachmann K et al. The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer. MOL CANCER RES. 2014 Mai 1;12(5):670-80. https://doi.org/10.1158/1541-7786.MCR-13-0467

Bibtex

@article{d2ecfd64db6447a9a3f9a5df846f8176,
title = "The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis among solid tumors and despite increased knowledge of the molecular mechanisms contributing to progression and metastasis, minimal progress has been done in establishing new targeted therapies for this deadly disease. The expression of the multifunctional growth/differentiation factor midkine (MK) promotes a variety of cellular functions leading to increased angiogenesis, proliferation, migration, and survival. Moreover, MK is intensively discussed as a potential new-therapy target and as biomarker for cancer progression and chemotherapeutic resistance in multiple cancers. Therefore, the present study investigated the molecular role of MK in pancreatic cancer. It was found that MK is elevated in PDAC and differentially expressed in other histologic subtypes of pancreatic cancer, whereas normal pancreatic cells did not express MK, thus making it an attractive candidate for targeted therapies. As a secreted growth/differentiation factor, MK was investigated as a biomarker in clinical serum specimens using ELISA. In addition, knockdown studies of MK revealed a link to proliferation and migration status in vitro. Finally, upstream signaling pathways were analyzed, with TNF-α and EGF being the main inductors of MK expression in PDAC. Implications: This study presents novel MK functions and new upstream signaling effectors that induce its expression to promote PDAC and therefore defines an attractive new therapeutic target in pancreatic cancer. Mol Cancer Res; 12(5); 670-80. {\textcopyright}2014 AACR.",
author = "Tamina Rawnaq and Luisa Dietrich and Gerrit Wolters-Eisfeld and Uzunoglu, {Faik G} and Vashist, {Yogesh K} and Kai Bachmann and Ronald Simon and Izbicki, {Jakob R} and Maximilian Bockhorn and Cenap G{\"u}ng{\"o}r",
year = "2014",
month = may,
day = "1",
doi = "10.1158/1541-7786.MCR-13-0467",
language = "English",
volume = "12",
pages = "670--80",
journal = "MOL CANCER RES",
issn = "1541-7786",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer

AU - Rawnaq, Tamina

AU - Dietrich, Luisa

AU - Wolters-Eisfeld, Gerrit

AU - Uzunoglu, Faik G

AU - Vashist, Yogesh K

AU - Bachmann, Kai

AU - Simon, Ronald

AU - Izbicki, Jakob R

AU - Bockhorn, Maximilian

AU - Güngör, Cenap

PY - 2014/5/1

Y1 - 2014/5/1

N2 - Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis among solid tumors and despite increased knowledge of the molecular mechanisms contributing to progression and metastasis, minimal progress has been done in establishing new targeted therapies for this deadly disease. The expression of the multifunctional growth/differentiation factor midkine (MK) promotes a variety of cellular functions leading to increased angiogenesis, proliferation, migration, and survival. Moreover, MK is intensively discussed as a potential new-therapy target and as biomarker for cancer progression and chemotherapeutic resistance in multiple cancers. Therefore, the present study investigated the molecular role of MK in pancreatic cancer. It was found that MK is elevated in PDAC and differentially expressed in other histologic subtypes of pancreatic cancer, whereas normal pancreatic cells did not express MK, thus making it an attractive candidate for targeted therapies. As a secreted growth/differentiation factor, MK was investigated as a biomarker in clinical serum specimens using ELISA. In addition, knockdown studies of MK revealed a link to proliferation and migration status in vitro. Finally, upstream signaling pathways were analyzed, with TNF-α and EGF being the main inductors of MK expression in PDAC. Implications: This study presents novel MK functions and new upstream signaling effectors that induce its expression to promote PDAC and therefore defines an attractive new therapeutic target in pancreatic cancer. Mol Cancer Res; 12(5); 670-80. ©2014 AACR.

AB - Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis among solid tumors and despite increased knowledge of the molecular mechanisms contributing to progression and metastasis, minimal progress has been done in establishing new targeted therapies for this deadly disease. The expression of the multifunctional growth/differentiation factor midkine (MK) promotes a variety of cellular functions leading to increased angiogenesis, proliferation, migration, and survival. Moreover, MK is intensively discussed as a potential new-therapy target and as biomarker for cancer progression and chemotherapeutic resistance in multiple cancers. Therefore, the present study investigated the molecular role of MK in pancreatic cancer. It was found that MK is elevated in PDAC and differentially expressed in other histologic subtypes of pancreatic cancer, whereas normal pancreatic cells did not express MK, thus making it an attractive candidate for targeted therapies. As a secreted growth/differentiation factor, MK was investigated as a biomarker in clinical serum specimens using ELISA. In addition, knockdown studies of MK revealed a link to proliferation and migration status in vitro. Finally, upstream signaling pathways were analyzed, with TNF-α and EGF being the main inductors of MK expression in PDAC. Implications: This study presents novel MK functions and new upstream signaling effectors that induce its expression to promote PDAC and therefore defines an attractive new therapeutic target in pancreatic cancer. Mol Cancer Res; 12(5); 670-80. ©2014 AACR.

U2 - 10.1158/1541-7786.MCR-13-0467

DO - 10.1158/1541-7786.MCR-13-0467

M3 - SCORING: Journal article

C2 - 24567526

VL - 12

SP - 670

EP - 680

JO - MOL CANCER RES

JF - MOL CANCER RES

SN - 1541-7786

IS - 5

ER -