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The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

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The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. / Stittrich, Anna-Barbara; Haftmann, Claudia; Sgouroudis, Evridiki; Kühl, Anja Andrea; Hegazy, Ahmed Nabil; Panse, Isabel; Riedel, Rene; Flossdorf, Michael; Dong, Jun; Fuhrmann, Franziska; Heinz, Gitta Anne; Fang, Zhuo; Li, Na; Bissels, Ute; Hatam, Farahnaz; Jahn, Angelina; Hammoud, Ben; Matz, Mareen; Schulze, Felix-Michael; Baumgrass, Ria; Bosio, Andreas; Mollenkopf, Hans-Joachim; Grün, Joachim; Thiel, Andreas; Chen, Wei; Höfer, Thomas; Loddenkemper, Christoph; Löhning, Max; Chang, Hyun-Dong; Rajewsky, Nikolaus; Radbruch, Andreas; Mashreghi, Mir-Farzin.

in: NAT IMMUNOL, Jahrgang 11, Nr. 11, 11.2010, S. 1057-62.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Stittrich, A-B, Haftmann, C, Sgouroudis, E, Kühl, AA, Hegazy, AN, Panse, I, Riedel, R, Flossdorf, M, Dong, J, Fuhrmann, F, Heinz, GA, Fang, Z, Li, N, Bissels, U, Hatam, F, Jahn, A, Hammoud, B, Matz, M, Schulze, F-M, Baumgrass, R, Bosio, A, Mollenkopf, H-J, Grün, J, Thiel, A, Chen, W, Höfer, T, Loddenkemper, C, Löhning, M, Chang, H-D, Rajewsky, N, Radbruch, A & Mashreghi, M-F 2010, 'The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes', NAT IMMUNOL, Jg. 11, Nr. 11, S. 1057-62. https://doi.org/10.1038/ni.1945

APA

Stittrich, A-B., Haftmann, C., Sgouroudis, E., Kühl, A. A., Hegazy, A. N., Panse, I., Riedel, R., Flossdorf, M., Dong, J., Fuhrmann, F., Heinz, G. A., Fang, Z., Li, N., Bissels, U., Hatam, F., Jahn, A., Hammoud, B., Matz, M., Schulze, F-M., ... Mashreghi, M-F. (2010). The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. NAT IMMUNOL, 11(11), 1057-62. https://doi.org/10.1038/ni.1945

Vancouver

Stittrich A-B, Haftmann C, Sgouroudis E, Kühl AA, Hegazy AN, Panse I et al. The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. NAT IMMUNOL. 2010 Nov;11(11):1057-62. https://doi.org/10.1038/ni.1945

Bibtex

@article{9d3c0f084885486a8a067fae443625c5,
title = "The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes",
abstract = "After being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in resting helper T lymphocytes. In the early antigen-dependent phase of expansion, Foxo1 is inactivated by antigen receptor-mediated post-translational modifications. Here we show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. Specific inhibition of miR-182 in helper T lymphocytes limited their population expansion in vitro and in vivo. Our results demonstrate a central role for miR-182 in the physiological regulation of IL-2-driven helper T cell-mediated immune responses and open new therapeutic possibilities.",
keywords = "Animals, Arthritis/immunology, Cell Proliferation, Cells, Cultured, Disease Models, Animal, Humans, Interleukin-2/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, MicroRNAs/immunology, T-Lymphocytes, Helper-Inducer/cytology",
author = "Anna-Barbara Stittrich and Claudia Haftmann and Evridiki Sgouroudis and K{\"u}hl, {Anja Andrea} and Hegazy, {Ahmed Nabil} and Isabel Panse and Rene Riedel and Michael Flossdorf and Jun Dong and Franziska Fuhrmann and Heinz, {Gitta Anne} and Zhuo Fang and Na Li and Ute Bissels and Farahnaz Hatam and Angelina Jahn and Ben Hammoud and Mareen Matz and Felix-Michael Schulze and Ria Baumgrass and Andreas Bosio and Hans-Joachim Mollenkopf and Joachim Gr{\"u}n and Andreas Thiel and Wei Chen and Thomas H{\"o}fer and Christoph Loddenkemper and Max L{\"o}hning and Hyun-Dong Chang and Nikolaus Rajewsky and Andreas Radbruch and Mir-Farzin Mashreghi",
year = "2010",
month = nov,
doi = "10.1038/ni.1945",
language = "English",
volume = "11",
pages = "1057--62",
journal = "NAT IMMUNOL",
issn = "1529-2908",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

AU - Stittrich, Anna-Barbara

AU - Haftmann, Claudia

AU - Sgouroudis, Evridiki

AU - Kühl, Anja Andrea

AU - Hegazy, Ahmed Nabil

AU - Panse, Isabel

AU - Riedel, Rene

AU - Flossdorf, Michael

AU - Dong, Jun

AU - Fuhrmann, Franziska

AU - Heinz, Gitta Anne

AU - Fang, Zhuo

AU - Li, Na

AU - Bissels, Ute

AU - Hatam, Farahnaz

AU - Jahn, Angelina

AU - Hammoud, Ben

AU - Matz, Mareen

AU - Schulze, Felix-Michael

AU - Baumgrass, Ria

AU - Bosio, Andreas

AU - Mollenkopf, Hans-Joachim

AU - Grün, Joachim

AU - Thiel, Andreas

AU - Chen, Wei

AU - Höfer, Thomas

AU - Loddenkemper, Christoph

AU - Löhning, Max

AU - Chang, Hyun-Dong

AU - Rajewsky, Nikolaus

AU - Radbruch, Andreas

AU - Mashreghi, Mir-Farzin

PY - 2010/11

Y1 - 2010/11

N2 - After being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in resting helper T lymphocytes. In the early antigen-dependent phase of expansion, Foxo1 is inactivated by antigen receptor-mediated post-translational modifications. Here we show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. Specific inhibition of miR-182 in helper T lymphocytes limited their population expansion in vitro and in vivo. Our results demonstrate a central role for miR-182 in the physiological regulation of IL-2-driven helper T cell-mediated immune responses and open new therapeutic possibilities.

AB - After being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in resting helper T lymphocytes. In the early antigen-dependent phase of expansion, Foxo1 is inactivated by antigen receptor-mediated post-translational modifications. Here we show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. Specific inhibition of miR-182 in helper T lymphocytes limited their population expansion in vitro and in vivo. Our results demonstrate a central role for miR-182 in the physiological regulation of IL-2-driven helper T cell-mediated immune responses and open new therapeutic possibilities.

KW - Animals

KW - Arthritis/immunology

KW - Cell Proliferation

KW - Cells, Cultured

KW - Disease Models, Animal

KW - Humans

KW - Interleukin-2/immunology

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred C57BL

KW - MicroRNAs/immunology

KW - T-Lymphocytes, Helper-Inducer/cytology

U2 - 10.1038/ni.1945

DO - 10.1038/ni.1945

M3 - SCORING: Journal article

C2 - 20935646

VL - 11

SP - 1057

EP - 1062

JO - NAT IMMUNOL

JF - NAT IMMUNOL

SN - 1529-2908

IS - 11

ER -