The matrix corroded
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The matrix corroded : podosomes and invadopodia in extracellular matrix degradation. / Linder, Stefan.
in: TRENDS CELL BIOL, Jahrgang 17, Nr. 3, 01.03.2007, S. 107-17.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The matrix corroded
T2 - podosomes and invadopodia in extracellular matrix degradation
AU - Linder, Stefan
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to the substratum but can also degrade components of the extracellular matrix. Accordingly, matrix degradation localized at podosomes or invadopodia is thought to contribute to cellular invasiveness in physiological and pathological situations. Cell types that form podosomes include monocytic, endothelial and smooth muscle cells, whereas invadopodia have been mostly observed in carcinoma cells. This review highlights important new developments in the field, discusses the common and divergent features of podosomes and invadopodia and summarizes current knowledge about matrix-degrading proteinases at these structures.
AB - Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to the substratum but can also degrade components of the extracellular matrix. Accordingly, matrix degradation localized at podosomes or invadopodia is thought to contribute to cellular invasiveness in physiological and pathological situations. Cell types that form podosomes include monocytic, endothelial and smooth muscle cells, whereas invadopodia have been mostly observed in carcinoma cells. This review highlights important new developments in the field, discusses the common and divergent features of podosomes and invadopodia and summarizes current knowledge about matrix-degrading proteinases at these structures.
KW - Animals
KW - Cell Adhesion
KW - Cell Surface Extensions
KW - Cytoskeleton
KW - Extracellular Matrix
KW - Humans
KW - Peptide Hydrolases
KW - Signal Transduction
U2 - 10.1016/j.tcb.2007.01.002
DO - 10.1016/j.tcb.2007.01.002
M3 - SCORING: Journal article
C2 - 17275303
VL - 17
SP - 107
EP - 117
JO - TRENDS CELL BIOL
JF - TRENDS CELL BIOL
SN - 0962-8924
IS - 3
ER -