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The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells

Standard

The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells. / Dumenieu, Mael; Senkov, Oleg; Mironov, Andrey; Bourinet, Emmanuel; Kreutz, Michael R; Dityatev, Alexander; Heine, Martin; Bikbaev, Arthur; Lopez-Rojas, Jeffrey.

in: CEREB CORTEX, Jahrgang 28, Nr. 7, 01.07.2018, S. 2594-2609.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dumenieu, M, Senkov, O, Mironov, A, Bourinet, E, Kreutz, MR, Dityatev, A, Heine, M, Bikbaev, A & Lopez-Rojas, J 2018, 'The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells', CEREB CORTEX, Jg. 28, Nr. 7, S. 2594-2609. https://doi.org/10.1093/cercor/bhy084

APA

Dumenieu, M., Senkov, O., Mironov, A., Bourinet, E., Kreutz, M. R., Dityatev, A., Heine, M., Bikbaev, A., & Lopez-Rojas, J. (2018). The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells. CEREB CORTEX, 28(7), 2594-2609. https://doi.org/10.1093/cercor/bhy084

Vancouver

Dumenieu M, Senkov O, Mironov A, Bourinet E, Kreutz MR, Dityatev A et al. The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells. CEREB CORTEX. 2018 Jul 1;28(7):2594-2609. https://doi.org/10.1093/cercor/bhy084

Bibtex

@article{463f9ba3f21e4a74a3239d801af80dd9,
title = "The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells",
abstract = "Mature granule cells are poorly excitable neurons that were recently shown to fire action potentials, preferentially in bursts. It is believed that the particularly pronounced short-term facilitation of mossy fiber synapses makes granule cell bursting a very effective means of properly transferring information to CA3. However, the mechanism underlying the unique bursting behavior of mature granule cells is currently unknown. Here, we show that Cav3.2 T-type channels at the axon initial segment are responsible for burst firing of mature granule cells in rats and mice. Accordingly, Cav3.2 knockout mice fire tonic spikes and exhibit impaired bursting, synaptic plasticity and dentate-to-CA3 communication. The data show that Cav3.2 channels are strong modulators of bursting and can be considered a critical molecular switch that enables effective information transfer from mature granule cells to the CA3 pyramids.",
keywords = "Journal Article",
author = "Mael Dumenieu and Oleg Senkov and Andrey Mironov and Emmanuel Bourinet and Kreutz, {Michael R} and Alexander Dityatev and Martin Heine and Arthur Bikbaev and Jeffrey Lopez-Rojas",
year = "2018",
month = jul,
day = "1",
doi = "10.1093/cercor/bhy084",
language = "English",
volume = "28",
pages = "2594--2609",
journal = "CEREB CORTEX",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells

AU - Dumenieu, Mael

AU - Senkov, Oleg

AU - Mironov, Andrey

AU - Bourinet, Emmanuel

AU - Kreutz, Michael R

AU - Dityatev, Alexander

AU - Heine, Martin

AU - Bikbaev, Arthur

AU - Lopez-Rojas, Jeffrey

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Mature granule cells are poorly excitable neurons that were recently shown to fire action potentials, preferentially in bursts. It is believed that the particularly pronounced short-term facilitation of mossy fiber synapses makes granule cell bursting a very effective means of properly transferring information to CA3. However, the mechanism underlying the unique bursting behavior of mature granule cells is currently unknown. Here, we show that Cav3.2 T-type channels at the axon initial segment are responsible for burst firing of mature granule cells in rats and mice. Accordingly, Cav3.2 knockout mice fire tonic spikes and exhibit impaired bursting, synaptic plasticity and dentate-to-CA3 communication. The data show that Cav3.2 channels are strong modulators of bursting and can be considered a critical molecular switch that enables effective information transfer from mature granule cells to the CA3 pyramids.

AB - Mature granule cells are poorly excitable neurons that were recently shown to fire action potentials, preferentially in bursts. It is believed that the particularly pronounced short-term facilitation of mossy fiber synapses makes granule cell bursting a very effective means of properly transferring information to CA3. However, the mechanism underlying the unique bursting behavior of mature granule cells is currently unknown. Here, we show that Cav3.2 T-type channels at the axon initial segment are responsible for burst firing of mature granule cells in rats and mice. Accordingly, Cav3.2 knockout mice fire tonic spikes and exhibit impaired bursting, synaptic plasticity and dentate-to-CA3 communication. The data show that Cav3.2 channels are strong modulators of bursting and can be considered a critical molecular switch that enables effective information transfer from mature granule cells to the CA3 pyramids.

KW - Journal Article

U2 - 10.1093/cercor/bhy084

DO - 10.1093/cercor/bhy084

M3 - SCORING: Journal article

C2 - 29790938

VL - 28

SP - 2594

EP - 2609

JO - CEREB CORTEX

JF - CEREB CORTEX

SN - 1047-3211

IS - 7

ER -