PortalPublikationenThe low-dose dexamethasone suppression test in fibromyalgia.

The low-dose dexamethasone suppression test in fibromyalgia.

Standard

The low-dose dexamethasone suppression test in fibromyalgia. / Wingenfeld, Katja; Wagner, Dieter; Schmidt, Iris; Meinlschmidt, Gunther; Hellhammer, Dirk H; Heim, Christine.

in: J PSYCHOSOM RES, Jahrgang 62, Nr. 1, 1, 2007, S. 85-91.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wingenfeld, K, Wagner, D, Schmidt, I, Meinlschmidt, G, Hellhammer, DH & Heim, C 2007, 'The low-dose dexamethasone suppression test in fibromyalgia.', J PSYCHOSOM RES, Jg. 62, Nr. 1, 1, S. 85-91. <http://www.ncbi.nlm.nih.gov/pubmed/17188125?dopt=Citation>

APA

Wingenfeld, K., Wagner, D., Schmidt, I., Meinlschmidt, G., Hellhammer, D. H., & Heim, C. (2007). The low-dose dexamethasone suppression test in fibromyalgia. J PSYCHOSOM RES, 62(1), 85-91. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17188125?dopt=Citation

Vancouver

Wingenfeld K, Wagner D, Schmidt I, Meinlschmidt G, Hellhammer DH, Heim C. The low-dose dexamethasone suppression test in fibromyalgia. J PSYCHOSOM RES. 2007;62(1):85-91. 1.

Bibtex

@article{4e323a2c138a4730840e2e3cc5a5dcdb,
title = "The low-dose dexamethasone suppression test in fibromyalgia.",
abstract = "OBJECTIVE: Fibromyalgia syndrome (FMS) has been associated with decreased cortisol secretion. Patients with posttraumatic stress disorder (PTSD) exhibit similar hypocortisolism in the context of increased negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis. Because trauma and PTSD have been associated with fibromyalgia, we evaluated whether patients with fibromyalgia demonstrate increased HPA feedback sensitivity. METHOD: Baseline blood samples were obtained at 0800 h, and 0.5 mg of dexamethasone was administered to 15 female patients with FMS and 20 normal controls at 2300 h. Adrenocorticotropin (ACTH), cortisol, and dexamethasone levels were measured at 0800 h after dexamethasone intake. RESULTS: There were no group differences in mean ACTH or cortisol levels or in ACTH/cortisol ratio at baseline. After dexamethasone intake, patients with FMS exhibited more pronounced suppression of cortisol but not of ACTH, as well as increased ACTH/cortisol ratios compared with controls. Percent cortisol suppression was associated with pain and fatigue, while ACTH/cortisol ratio and dexamethasone availability were associated with stress and anxiety measures. CONCLUSION: Our results suggest increased sensitivity to glucocorticoid feedback, manifested at the adrenal level, in FMS.",
author = "Katja Wingenfeld and Dieter Wagner and Iris Schmidt and Gunther Meinlschmidt and Hellhammer, {Dirk H} and Christine Heim",
year = "2007",
language = "Deutsch",
volume = "62",
pages = "85--91",
journal = "J PSYCHOSOM RES",
issn = "0022-3999",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - The low-dose dexamethasone suppression test in fibromyalgia.

AU - Wingenfeld, Katja

AU - Wagner, Dieter

AU - Schmidt, Iris

AU - Meinlschmidt, Gunther

AU - Hellhammer, Dirk H

AU - Heim, Christine

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: Fibromyalgia syndrome (FMS) has been associated with decreased cortisol secretion. Patients with posttraumatic stress disorder (PTSD) exhibit similar hypocortisolism in the context of increased negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis. Because trauma and PTSD have been associated with fibromyalgia, we evaluated whether patients with fibromyalgia demonstrate increased HPA feedback sensitivity. METHOD: Baseline blood samples were obtained at 0800 h, and 0.5 mg of dexamethasone was administered to 15 female patients with FMS and 20 normal controls at 2300 h. Adrenocorticotropin (ACTH), cortisol, and dexamethasone levels were measured at 0800 h after dexamethasone intake. RESULTS: There were no group differences in mean ACTH or cortisol levels or in ACTH/cortisol ratio at baseline. After dexamethasone intake, patients with FMS exhibited more pronounced suppression of cortisol but not of ACTH, as well as increased ACTH/cortisol ratios compared with controls. Percent cortisol suppression was associated with pain and fatigue, while ACTH/cortisol ratio and dexamethasone availability were associated with stress and anxiety measures. CONCLUSION: Our results suggest increased sensitivity to glucocorticoid feedback, manifested at the adrenal level, in FMS.

AB - OBJECTIVE: Fibromyalgia syndrome (FMS) has been associated with decreased cortisol secretion. Patients with posttraumatic stress disorder (PTSD) exhibit similar hypocortisolism in the context of increased negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis. Because trauma and PTSD have been associated with fibromyalgia, we evaluated whether patients with fibromyalgia demonstrate increased HPA feedback sensitivity. METHOD: Baseline blood samples were obtained at 0800 h, and 0.5 mg of dexamethasone was administered to 15 female patients with FMS and 20 normal controls at 2300 h. Adrenocorticotropin (ACTH), cortisol, and dexamethasone levels were measured at 0800 h after dexamethasone intake. RESULTS: There were no group differences in mean ACTH or cortisol levels or in ACTH/cortisol ratio at baseline. After dexamethasone intake, patients with FMS exhibited more pronounced suppression of cortisol but not of ACTH, as well as increased ACTH/cortisol ratios compared with controls. Percent cortisol suppression was associated with pain and fatigue, while ACTH/cortisol ratio and dexamethasone availability were associated with stress and anxiety measures. CONCLUSION: Our results suggest increased sensitivity to glucocorticoid feedback, manifested at the adrenal level, in FMS.

M3 - SCORING: Zeitschriftenaufsatz

VL - 62

SP - 85

EP - 91

JO - J PSYCHOSOM RES

JF - J PSYCHOSOM RES

SN - 0022-3999

IS - 1

M1 - 1

ER -